Norovirus GII.4 Antibodies in Breast Milk and Serum Samples

Khodayar-Pardo, Parisá; Martínez‐Costa, Cecilia; Carmona-Vicente, Noelia; Buesa, Javier

doi:10.1097/inf.0000000000000207

Cited by 12 publications

(11 citation statements)

References 34 publications

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“…We showed that breast milk samples collected before and during the first NV infection of infants contained multiple NV-IgA using an in-house ELISA-based method which was concordant with the previous studies on postpartum breast milk [14] , [15] , [16] . In our study, Peruvian mothers had a higher percent positivity (61–100%) of NV-IgA in breast milk than mothers in these studies.…”

Section: Discussionsupporting

confidence: 89%

“…Previous studies showed that breast milk collected postpartum reacted to various NV virus-like particles (VLPs), but the protective ability of NV-specific IgA (NV-IgA) is yet to be established [14] , [15] , [16] . In this study, we evaluated the linkage of NV-IgA in breast milk with protection against NV and found that (i) NV-IgA reacted against GII·4 variants and non-GII·4 genotype VLPS, and (ii) high titer of NV-IgA was associated to the reduction of diarrheal symptoms in NV infected infants.…”

Section: Introductionmentioning

confidence: 99%

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Norovirus-specific immunoglobulin A in breast milk for protection against norovirus-associated diarrhea among infants

et al. 2020

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Background Norovirus (NV) causes acute gastroenteritis in infants. Humoral and fecal immunoglobulin A (IgA) responses have been correlated with protection against NV; however, the role of breast milk IgA against NV infection and associated diarrhea is still unknown. This study aimed to evaluate the protective role of NV-specific IgA (NV-IgA) in breast milk. Methods Ninety-five breast milk samples collected from mothers enrolled in a 2016–2017 Peruvian birth cohort study were tested for total IgA and NV-IgA by ELISA using GII·4 variants and non-GII·4 genotype virus-like particles (VLPs). Breast milk samples were grouped according to the NV infection and diarrheal status of infants: NV positive with diarrhea (NV+D+, n=18); NV positive without diarrhea (NV+D-, n=37); and NV negative without diarrhea (NV-D-, n=40). The percent positivity and titer of NV-IgA were compared among groups. The cross-reactivity was estimated based on the correlation of ratio between NV-IgA against GII·4 variants and non-GII·4 genotype VLPs. Findings NV-IgA had high positivity rates against different VLPs, especially against GII (89–100%). The NV+D- group had higher percent positivity (89% vs. 61%, p=0·03) and median titer (1:100 vs 1:50, p=0·03) of NV-IgA than the NV+D+ group against GI·1 VLPs. A relatively high correlation between different GII·4 variants (0·87) and low correlation between genogroups (0·23–0·37) were observed. Interpretation Mothers with high positivity rates and titers of NV-IgA in breast milk had NV infected infants with reduced diarrheal symptoms. Antigenic relatedness to the genetic diversity of human norovirus was suggested. Funding National Institute of Allergy and Infectious Diseases, National Institute of Health: 1R01AI108695–01A1 and the Japan Society for the Promotion of Science (Fostering Joint International Research B):19KK0241

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Norovirus-specific immunoglobulin A in breast milk for protection against norovirus-associated diarrhea among infants

et al. 2020

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“…Studies have shown that human breast milk from mothers with the secretor phenotype contains fucosylated oligosaccharides, which can act as such a blockade against the binding of norovirus virus–like particles [30, 31]. …”

Section: Discussionmentioning

confidence: 99%

Host Genetic Susceptibility to Enteric Viruses: A Systematic Review and Metaanalysis

et al. 2015

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Background Norovirus and rotavirus are prominent enteric viruses responsible for severe acute gastroenteritis disease burden around the world. Both viruses recognize and bind to histo-blood group antigens, which are expressed by the fucosyltransferase 2 (FUT2) gene. Individuals with a functional FUT2 gene are termed “secretors.” FUT2 polymorphisms may influence viral binding patterns and, therefore, may influence host susceptibility to infection by these viruses. Methods We performed a systematic review of the published literature on this topic. Data were abstracted and compiled for descriptive analyses and metaanalyses. We estimated pooled odds ratios (ORs) for infection using random-effects models. Results We found that secretors were 9.9 times (95% confidence interval [CI], 3.9–24.8) as likely to be infected with genogroup II.4 noroviruses and 2.2 times as likely to be infected with genogroup II non-4 noroviruses (95% CI, 1.2–4.2) compared with nonsecretors. Secretors were also 26.6 times more susceptible to infections from P[8]-type rotaviruses compared with nonsecretors (95% CI, 8.3–85.0). Conclusions Our analyses indicate that host genetic susceptibility to norovirus and rotavirus infection may be strain specific. As strain distribution and the proportion of genetic phenotypes vary in different countries, future studies should focus on differences in susceptibility among various ethnicities. Knowledge of innate susceptibility to rotavirus and norovirus can lead to improved understanding of both vaccine performance and individual risk of disease.

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“…Here, the Lewis blood group and secretor status of the mother are of particular importance. They are currently discussed to have an influence on inflammatory gastrointestinal diseases, on adverse outcomes in low-birth-weight infants or on diarrhea (17)(18)(19)(20)(21)(22)(23). Feeding infants with a different HMO pattern may reduce or even increase the risk for certain diseases.…”

Section: What Is Newmentioning

confidence: 99%

Influence of Gestational Age, Secretor, and Lewis Blood Group Status on the Oligosaccharide Content of Human Milk

Kunz

Meyer

Collado

et al. 2017

J. pediatr. gastroenterol. nutr.

183

218

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Norovirus GII.4 Antibodies in Breast Milk and Serum Samples

Cited by 12 publications

References 34 publications

Norovirus-specific immunoglobulin A in breast milk for protection against norovirus-associated diarrhea among infants

Norovirus-specific immunoglobulin A in breast milk for protection against norovirus-associated diarrhea among infants

Host Genetic Susceptibility to Enteric Viruses: A Systematic Review and Metaanalysis

Influence of Gestational Age, Secretor, and Lewis Blood Group Status on the Oligosaccharide Content of Human Milk

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