Norovirus and Histo-Blood Group Antigens: Demonstration of a Wide Spectrum of Strain Specificities and Classification of Two Major Binding Groups among Multiple Binding Patterns

Huang, Pengwei; Farkas, Tibor; Zhong, Weiming; Tan, Ming; Thornton, Scott A.; Morrow, Ardythe L.; Jiang, Xi

doi:10.1128/jvi.79.11.6714-6722.2005

Cited by 366 publications

(477 citation statements)

References 23 publications

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“…However, since 2002 and the spread of the Farmington variants, laboratory networks have observed an increasing pace in the genetic drift, with the emergence of new GII.4 variants every 2 or 3 years (40). Thorough analysis of the attachment of NoVs belonging to several genotypes allowed the characterization of eight binding profiles (16,17), which can be classified into the ABO and Lewis binding groups. GII.4 NoVs present the widest binding spectrum since they can attach efficiently to saliva from secretor ABO individuals (80% of the Caucasian population), as reviewed previously (47).…”

Section: Discussionmentioning

confidence: 99%

Qualitative and Quantitative Analysis of the Binding of GII.4 Norovirus Variants onto Human Blood Group Antigens

Rougemont¹,

Ruvoën-Clouet

Benoit

et al. 2011

J Virol

129

161

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Section: Discussionmentioning

confidence: 99%

Qualitative and Quantitative Analysis of the Binding of GII.4 Norovirus Variants onto Human Blood Group Antigens

Rougemont¹,

Ruvoën-Clouet

Benoit

et al. 2011

J Virol

129

161

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“…These viruses bind to synthetic HBGA structures or HBGAs present in bodily secretions and on cell surfaces. At least eight different in vitro HBGA binding patterns have been identified among human NoVs, involving the ABO-and Lewis-type HBGAs (Huang et al, 2005 HBGA binding and susceptibility to infection for the Norwalk virus and more recently for a G2.4 human NoV, revealing a key role of the secretor status linked with function of the FUT2 gene (Frenck et al, 2012;Lindesmith et al, 2003). However, for the Snow Mountain virus, which binds to type B HBGA, an association between in vitro HBGA binding and susceptibility could not be established (Lindesmith et al, 2005).…”

Section: Recv-hbga Interactionsmentioning

confidence: 99%

Rhesus enteric calicivirus surrogate model for human norovirus gastroenteritis

Farkas

2015

Journal of General Virology

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Human noroviruses are one of the major causes of acute gastroenteritis worldwide. Due to the lack of an efficient human norovirus cell culture system coupled with an animal model, human norovirus research mainly relies on human volunteer studies and surrogate models. Current models either utilize human norovirus-infected animals including the gnotobiotic pig or calf and the chimpanzee models, or employ other members of the family Caliciviridae including cell culture propagable surrogate caliciviruses such as the feline calicivirus, murine norovirus and most recently the Tulane virus. One of the major features of human noroviruses is their extreme biological diversity, including genetic, antigenic and histo-blood group antigen binding diversity, and possible differences of virulence and environmental stability. This extreme biological diversity and its effect on intervention/prevention strategies cannot be modelled by uniform groups of surrogates, much less by single isolates. Tulane virus, the prototype recovirus strain, was discovered in 2008. Since then, several other novel recoviruses have been described and cell culture adapted. Recent studies indicate that the epidemiology, the biological features and diversity of recoviruses and the course of infection and clinical disease in recovirus-infected macaques more closely reflect those properties of human noroviruses than any of the current surrogates. This review aims to summarize what is currently known about recoviruses, highlight their biological similarities to human noroviruses and discuss applications of the model in addressing questions relevant for human norovirus research.

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“…Outbreak investigations have confirmed the association between HBGA expression and norovirus infection for some GI and GII strains (37,39,43,49,89). It remains likely that enzymes other than FUT2 may function as norovirus susceptibility factors because secretor-negative individuals have low-level norovirus-reactive antibodies (49,52,53) and can become infected after challenge with a GII.2 strain (52); in addition, some norovirus strains bind to FUT2-independent HBGAs in vitro (35,54,79).…”

mentioning

confidence: 99%

Heterotypic Humoral and Cellular Immune Responses following Norwalk Virus Infection

Lindesmith

Donaldson

León

et al. 2010

J Virol

128

145

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Norovirus immunity is poorly understood as the limited data available on protection after infection are often contradictory. In contrast to the more prominent GII noroviruses, GI norovirus infections are less frequent in outbreaks. The GI noroviruses display very complex patterns of heterotypic immune responses following infection, and many individuals are highly susceptible to reinfection. To study the immune responses and mechanisms of GI.1 persistence, we built structural models and recombinant virus-like particles ( Noroviruses are the second-most important cause of severe viral gastroenteritis in young children and cause approximately 20% of endemic familial diarrheal disease and traveler's diarrhea in all ages (reviewed in references 45 and 70). Noroviruses are genetically grouped into five different genogroups (GI to GV). GI and GII genogroups are responsible for the majority of human infections and are subdivided into more than 25 different genotypes (for example, GI

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Norovirus and Histo-Blood Group Antigens: Demonstration of a Wide Spectrum of Strain Specificities and Classification of Two Major Binding Groups among Multiple Binding Patterns

Cited by 366 publications

References 23 publications

Qualitative and Quantitative Analysis of the Binding of GII.4 Norovirus Variants onto Human Blood Group Antigens

Qualitative and Quantitative Analysis of the Binding of GII.4 Norovirus Variants onto Human Blood Group Antigens

Rhesus enteric calicivirus surrogate model for human norovirus gastroenteritis

Heterotypic Humoral and Cellular Immune Responses following Norwalk Virus Infection

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