Nöroinflamasyonun Epileptogenezdeki Rolü ve Antiepileptojenik Tedavide Nöroinflamasyona Yönelik Hedefler

Abstract

Research in experimental epilepsy models and clinical investigations on epilepsy patients have provided important evidence that neuroinflammation has an effective role in epilepsy pathophysiology. Particularly, the effects of neuroinflammation-related pathways and mediators in the epileptogenesis process have been the subject of intensive research, and the elucidation of these processes has become important for the development of antiepileptogenic therapies and epileptogenic biomarkers. As a result of these studies, many pathophysiological processes have been determined and antiepileptogenic therapeutic targets have been defined. In this review, the main mechanisms involved in neuroinflammation in the epileptogenesis process are addressed and potential targets are reviewed focusing on developing antiepileptogenic therapy.