Normothermic cardiopulmonary bypass is beneficial for cognitive brain function after coronary artery bypass grafting — a prospective randomized trial✩

Abstract

Objective cognitive P300 auditory evoked potential measurements indicate, that subclinical impairment of cognitive brain function is more pronounced in patients undergoing mildly hypothermic CPB as compared with normothermic CPB for CABG.

Cognitive brain function after hypothermic circulatory arrest assessed by cognitive P300 evoked potentials

“…Cognitive P300 evoked potentials, a long-latency endogenous evoked potential associated with psychological processing of stimulus information, can provide a quantification of impaired cognitive brain function [9][10][11][12][13]15]. It has been also reported that P300 technique is more sensitive in detecting sub-clinical impairment of cognitive brain function than standard psychometric tests [10,13,15].…”

“…It has been also reported that P300 technique is more sensitive in detecting sub-clinical impairment of cognitive brain function than standard psychometric tests [10,13,15]. In addition, its high intra-individual reproducibility is further emphasized [13,15]. Therefore, P300 has been used to evaluate impaired cognitive brain dysfunction for various disorders from its beginnings in the 1980s [11].…”

“…The P300 wave, a long-latency event-related potential, is known to be associated with psychological processing of stimulus information and thus can provide a quantification of impaired cognitive brain function [11][12][13]. P300 latency increases with age and is a neuropsychological correlate of information processing, such as stimulus evaluation, alertness, and memory updating [14].…”

“…P300 latency increases with age and is a neuropsychological correlate of information processing, such as stimulus evaluation, alertness, and memory updating [14]. The use of the P300 technique has proved to be even more sensitive than electroencephalogram and standard psychometric tests for detecting sub-clinical impairment of cognitive brain function [10,13,15].…”

Effect of cardiopulmonary bypass on cortical cerebral oxygenation during coronary artery bypass grafting

“…However, others have reported a favourable outcome following normothermic CPB. Objective cognitive P300 auditoryevoked potential measurements have indicated cognitive impairment following hypothermic (32 8C) bypass to be more pronounced than during normothermic (37 8C) bypass [24]. Finally, McLean and colleagues were unable to Table 2 Changes in haemodynamics and cerebral cortical oxygenation during CPB demonstrate neuroprotective effects of moderate hypothermia as compared with normothermic CPB [25].…”