Normolipemic plane xanthoma associated with adenocarcinoma and severe itch

Broeshart, Jacqueline H.; Prens, Errol P.; Habets, Werner J.M.; Bruijckere, Leo M. de

doi:10.1067/mjd.2003.232

Cited by 7 publications

(5 citation statements)

References 15 publications

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“…[8] One case was reported to be associated with adenocarcinoma and severe itch, [3] and another case was associated with histiocytic lymphoma. [9] Several reported cases [10,11] of NPX were not associated with paraproteinemia or systemic disease and were regarded as idiopathic.…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous Normolipemic Plane Xanthoma with Supraglottic Involvement in a Patient with Hand-Schüller-Christian Disease

Chen

Chung

et al. 2009

American Journal of Clinical Dermatology

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Normolipemic plane xanthoma (NPX) is a histiocytic disorder characterized by yellow-orange plaques in the periorbital areas, neck, upper trunk, and flexural folds. Association with systemic disease or paraproteinemia has been reported previously, but rarely with Langerhans cell histiocytosis (LCH). We report a case of Hand-Schüller-Christian disease (a type of LCH) in a patient who developed NPX with supraglottic involvement. NPX developed after several courses of chemotherapy and the supraglottic xanthoma occurred about 2 years later. The coexistence of LCH and non-LCH histiocytic lesions in this patient could be a result of chemotherapy-induced changes or may be just coincidental.

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Section: Discussionmentioning

confidence: 99%

“…Previously reported cases of NPX were associated with lymphoproliferative diseases, monoclonal gammopathy, cryoglobulinemia, and adenocarcinoma. [2,3] We report a case of NPX with supraglottic involvement in a patient with HandSchu¨ller-Christian disease.…”

mentioning

confidence: 99%

Cutaneous Normolipemic Plane Xanthoma with Supraglottic Involvement in a Patient with Hand-Schüller-Christian Disease

Chen

Chung

et al. 2009

American Journal of Clinical Dermatology

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“…Bazı ksantom tiplerinde eşlik eden monoklonal gammopati bulunur (Tablo 2). Yassı ksantomlar hiperlipemik veya normolipemik olmak üzere 2 grupta sınıflanmaktadır 15 . Diffüz normolipemik yassı ksantom (DNYK), vücutta geniş alanlara yayılım gösterebilen sarımsı renk değişikliği ile karakterize ve sıklıkla sistemik hastalıklara eşlik eden bir formdur 16 .…”

Section: Diffüz Normolipemik Yassı Ksantomunclassified

“…Diffuz normolipemik yassı ksantom, idiopatik olabileceği gibi başta multipl miyelom (MM) ve diğer monoklonal gammopatiler olmak üzere çeşitli hematolojik hastalıklar veya lösemi ve lenfoma gibi lenfoproliferatif hastalıklar ile lipoprotein metabolizma bozukluklarına eşlik edebilir [15][16][17]19 . Nadir olarak mikozis fungoides gibi kutanöz T hücreli lenfomalar veya adenokarsinomlarla birlikte de görülebilir 15,19 . Sözkonusu malign hastalıklar DNYK'la eş zamanlı olarak bulgu verebileceği gibi, bu tanıdan uzun yıllar sonra da ortaya çıkabilir.…”

Section: Diffüz Normolipemik Yassı Ksantomunclassified

“…Tanı klinik ve histopatolojik bulgularla konur. Papiller ve orta dermiste diffüz, ancak perivasküler alanlarda yoğunlaşma gösteren histiyositik köpüksü hücreler ile lenfositlerden oluşan infiltrayon izlenir 15,16 . Nadir de olsa bazı olgularda nekrobiyotik ksantogranülomu (NKG) hatırlatan fokal nekrobiyoz ve Touton tipi dev hücreler de görülebilir 14 .…”

Section: Diffüz Normolipemik Yassı Ksantomunclassified

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