Normo Versus Hypofractionated Whole Breast Radiation-Related Acute Toxicities: Evolution over Time in Systematic Multicentric Real Life Data

Abstract

fibrosis and V20 (p Z 0.019), MLD (p Z 0.020) and regional lymphatic irradiation (p Z 0.030). V20 (p<0,001), MLD (p<0,001), regional lymphatic irradiation (p Z 0,030) and use of hormonotherapy (p<0,001) were effective in the formation of lung fibrosis in the 2nd year. Patients who received tamoxifen had more grade 2 fibrosis at the end of the second year than the patients who received control and aromatase inhibitors evaluated of hormone therapy(p<0,001). No relation was found between menopause status, age and taxane group chemotherapy and lung fibrosis development. Conclusion: The use of tamoxifen in patients receiving adjuvant radiotherapy for breast cancer increases the early and late lung fibrosis more than the aromatase inhibitors. However, V20, MLD, and regional lymph node irradiation also contribute to the frequency of fibrosis.