Normative ranges of biventricular volumes and function in healthy term newborns

Jhaveri, Simone; Battersby, Ellie; Stern, Kenan W.D.; Cohen, Jennifer; Yang, Yang; Price, Anthony N.; Hughes, Emer; Poston, Lucilla; Pasupathy, Dharmintra; Taylor, Paul D.; Vieira, Matias C.; Groves, Alan

doi:10.1186/s12968-023-00932-1

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…The absolute volumes of the third trimester fetuses measured here are 1–3 mL less than absolute SAX biventricular volumes reported in a cardiac MRI study of 20 healthy term neonates who were 40 weeks gestational age and 32 hours old 32 . When accounting for the difference in gestational age between the two studies, the correspondence of the measurements in this study with the results of newborn neonates is encouraging.…”

Section: Discussionsupporting

confidence: 57%

Reference Values for Fetal Cardiac Dimensions, Volumes, Ventricular Function and Left Ventricular Longitudinal Strain Using Doppler Ultrasound Gated Cardiac Magnetic Resonance Imaging in Healthy Third Trimester Fetuses

Minocha,

Englund,

Friesen

et al. 2023

Magnetic Resonance Imaging

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BackgroundRecent advances in hardware and software permit the use of cardiac MRI of late gestation fetuses, however there is a paucity of MRI‐based reference values.PurposeTo provide initial data on fetal cardiac MRI‐derived cardiac dimensions, volumes, ventricular function, and left ventricular longitudinal strain in healthy developing fetuses >30 weeks gestational age.Study TypeProspective.PopulationTwenty‐five third trimester (34 ± 1 weeks, range of 32–37 weeks gestation) women with healthy developing fetuses.Field Strength/SequenceStudies were performed at 1.5 T and 3 T. Cardiac synchronization was achieved with a Doppler ultrasound device. The protocol included T2 single shot turbo spin echo stacks for fetal weight and ultrasound probe positioning, and multiplanar multi‐slice cine balanced steady state free precession gradient echo sequences.AssessmentPrimary analyses were performed by a single observer. Weight indexed right ventricular (RV) and left ventricular (LV) volumes and function were calculated from short axis (SAX) stacks. Cardiac dimensions were calculated from the four‐chamber and SAX stacks. Single plane LV longitudinal strain was calculated from the four‐chamber stack. Interobserver variability was assessed in 10 participants. Cardiac MRI values were compared against available published normative fetal echocardiogram data using z‐scores.Statistical TestsMean and SDs were calculated for baseline maternal/fetal demographics, cardiac dimensions, volumes, ventricular function, and left ventricular longitudinal strain. Bland–Altman and intraclass correlation coefficient analysis was performed to test interobserver variability.ResultsThe mean gestational age was 34 ± 1.4 weeks. The mean RV and LV end diastolic volumes were 3.1 ± 0.6 mL/kg and 2.4 ± 0.5 mL/kg respectively. The mean RV cardiac output was 198 ± 49 mL/min/kg while the mean LV cardiac output was 173 ± 43 mL/min/kg.Data ConclusionThis paper reports initial reference values obtained by cardiac MRI in healthy developing third trimester fetuses. MRI generally resulted in slightly larger indexed values (by z‐score) compared to reports in literature using fetal echocardiography.Evidence level1Technical EfficacyStage 2

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Section: Discussionsupporting

confidence: 57%

Reference Values for Fetal Cardiac Dimensions, Volumes, Ventricular Function and Left Ventricular Longitudinal Strain Using Doppler Ultrasound Gated Cardiac Magnetic Resonance Imaging in Healthy Third Trimester Fetuses

Minocha,

Englund,

Friesen

et al. 2023

Magnetic Resonance Imaging

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Pediatric Z‐Score Calculator of Cardiac MRI Volumetric Measurements

Voges,

Caliebe,

Hinz

et al. 2024

Magnetic Resonance Imaging

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Cardiovascular MRI Reference Ranges for Heart, Aorta, and Pulmonary Artery in Healthy Chinese Children

Cao,

Peng,

Zhang

et al. 2024

Magnetic Resonance Imaging

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BackgroundCardiovascular magnetic resonance (cardiac MR) reference ranges in Chinese children are lacking.PurposeTo establish age‐ and sex‐specific reference ranges for cardiac MR parameters in a cohort of healthy Chinese children.Study TypeRetrospective.SubjectsOne hundred ninety‐six healthy children (mean age 9.5 ± 3.6 years, 111 boys).Field Strength/Sequence1.5 T; balanced steady‐state free precession.AssessmentBiventricular volume and ejection fractions (EF), left atrial (LA) volume, right atrial (RA) area, left ventricular (LV) mass and thickness, aortic root (AR), and main pulmonary artery (MPA) dimensions were measured. Parameters were compared between age groups and sex. The relationships between parameters and age, body mass index (BMI) and body surface area (BSA) were investigated.Statistical TestsIndependent‐samples t tests; Pearson's correlation. A P value <0.05 was considered statistically significant.ResultsGenerally, boys exhibited greater absolute measurements of LV volume (end‐diastolic: 94.4 ± 29.5 vs. 81.3 ± 31.0 mL), LA volume (end‐diastolic: 42.6 ± 13.4 vs. 38.0 ± 13.3 mL), RA area (end‐diastolic: 11.6 ± 2.5 vs. 10.8 ± 2.6 cm2), LV thickness (base: 4.4 ± 1.1 vs. 3.8 ± 0.9 mm), AR dimensions (annuls: 16.3 ± 2.7 vs. 15.0 ± 2.8 mm), and MPA dimensions (14.3 ± 2.3 vs. 13.1 ± 2.4 mm) than girls did. However, these differences were not observed when the measurements were normalized to BSA (LV volume: 75.3 ± 11.7 vs. 71.9 ± 12.3 mL/m2, P = 0.052; LA volume: 34.8 ± 8.9 vs. 34.5 ± 7.6 mL/m2, P = 0.783; RA area: 9.7 ± 2.3 vs. 10.2 ± 2.3 cm2/m2, P = 0.107; LV thickness: 3.6 ± 0.7 vs. 3.6 ± 0.9 mm/m2, P = 0.990; AR: 13.6 ± 2.7 vs. 14.3 ± 3.4 mm/m2, P = 0.108; MPA: 11.9 ± 2.3 vs. 12.4 ± 2.4 mm/m2, P = 0.118). Boys had greater RV volume (end‐diastolic: 98.7 ± 33.5 vs. 82.7 ± 33.1 mL) and LV mass (52.6 ± 20.2 vs. 41.4 ± 16.0 g) compared to girls, irrespective of whether the values were indexed or not for BSA. Additionally, there were significant associations between age, BMI, and BSA with biventricular volume, LA volume, RA area, LV mass and thickness, AR and MPA dimensions in both boys and girls.Data ConclusionThis study suggests reference ranges at 1.5 T for Chinese children.Evidence Level3Technical EfficacyStage 2

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Normative ranges of biventricular volumes and function in healthy term newborns

Cited by 3 publications

References 34 publications

Reference Values for Fetal Cardiac Dimensions, Volumes, Ventricular Function and Left Ventricular Longitudinal Strain Using Doppler Ultrasound Gated Cardiac Magnetic Resonance Imaging in Healthy Third Trimester Fetuses

Reference Values for Fetal Cardiac Dimensions, Volumes, Ventricular Function and Left Ventricular Longitudinal Strain Using Doppler Ultrasound Gated Cardiac Magnetic Resonance Imaging in Healthy Third Trimester Fetuses

Pediatric Z‐Score Calculator of Cardiac MRI Volumetric Measurements

Cardiovascular MRI Reference Ranges for Heart, Aorta, and Pulmonary Artery in Healthy Chinese Children

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