Abstract:Modelling population reference curves or normative modelling is increasingly used with the advent of large neuroimaging studies. In this paper we assess the performance of fitting methods from the perspective of clinical applications and investigate the influence of the sample size. Further, we evaluate linear and nonlinear models for percentile curve estimation and highlight how the bias-variance trade-off manifests in typical neuroimaging data.
We created plausible ground truth distributions of hippocampal v… Show more
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