Normative Modelling of Molecular-based Functional Neurocircuits Captures Clinical Heterogeneity Transdiagnostically in Neuropsychiatric Patients
Timothy Lawn,
Alessio Giacomel,
Daniel Martins
et al.
Abstract:Clinical neuroscience principally aims to delineate the neurobiology underpinning the symptoms of various disorders, with the ultimate goal of developing mechanistically informed treatments for these conditions. This has been hindered by the complex hierarchical organisation of the brain and extreme heterogeneity of neuropsychiatric disorders. However, recent advances in multimodal analytic techniques - such as Receptor Enriched Analysis of Connectivity by Targets (REACT) - have allowed to integrate the functi… Show more
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