Normative melatonin excretion: a multinational study

Wetterberg, Lennart; Bergiannaki, Joanne D.; Paparrigopoulos, Thomas; Knorring, Lars von; Eberhard, Göran; Bratlid, Trond; Yuwiler, Arthur

doi:10.1016/s0306-4530(98)00076-6

Cited by 65 publications

(53 citation statements)

References 72 publications

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“…Nevertheless, the values included here, obtained from samples taken in the early morning, are longitudinal (two measurements in the same subject, separated by one pubertal stage, approximately 1 year). Although melatonin levels tend to be higher in females throughout the lifespan [24, 25], only one previous paper from our group recorded differences during adolescence in the concentration of melatonin according to gender [4]; the results of the present study confirm that during puberty the values of serum melatonin tend to be higher in females. In addition, the variation between measurements was also greater among females, although without reaching statistical significance.…”

Section: Discussionsupporting

confidence: 80%

Longitudinal Study of the Simultaneous Secretion of Melatonin and Leptin during Normal Puberty

Molina-Carballo

Fernández-Tardáguila²,

Uberos‐Fernández³

et al. 2007

Horm Res Paediatr

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Background/Aims: Pubertal changes are a consequence of the activation of the hypothalamic-pituitary-gonadal axis due to an increase in the frequency and magnitude of pulses of gonadotropin-releasing hormone (GnRH), which may depend on the intrinsic properties of the neurons of the hypothalamic arcuatus nucleus, or on the influence of neurotransmitters and/or neuromodulators. We evaluated the serum concentrations of melatonin and leptin in healthy prepubertal and adolescent subjects of both sexes, to define their participation at the initial stages and during the progression of pubertal development. Methods: 80 pediatric subjects (47 females and 33 males), aged 6–18 years, were divided into 2 groups, prepubertal (n = 25) and adolescent (n = 55), according to the absence or presence, respectively, of physical signs of pubertal development. The subjects were assessed on two occasions: at the time of their inclusion in the study, and 12–18 months later when the subject had advanced one pubertal stage according to the Tanner classification. Blood was obtained in fasting for clinical purposes and for the hormonal study. Melatonin and leptin were measured by radioimmunoanalysis. Results: As described previously, melatonin decreases at the onset of puberty and during pubertal development. Both the absolute melatonin value and the decrease between evaluations tended to be greater in females; the variations were correlated with neither an increase in body weight nor with the degree of pubertal development. The concentration of leptin increased in both sexes with the progression of puberty, this value being 40% greater in women, and correlated with the indicators of an increase in body volume and fat accumulation. Although its concentration remained stable between evaluations for both sexes, among the males the association between leptin and pubertal development took place at the start of the process, while for the females we observed a significant overall association between pubertal stage and leptin concentration, this association being stronger at more advanced Tanner stages. Neither at the onset of puberty nor during its course did we observe any significant relation between melatonin concentration and any of the Tanner stages, whether for males or for females. Neither was there any correlation between the absolute values or rates of modification of melatonin and leptin. Conclusion: According to the evolutionary dynamics of their respective concentrations, both initially and during pubertal progress, melatonin and leptin do not interact in the initiation or progression of human pubertal development, and do not seem to play a key role in this process.

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Section: Discussionsupporting

confidence: 80%

Longitudinal Study of the Simultaneous Secretion of Melatonin and Leptin during Normal Puberty

Molina-Carballo

Fernández-Tardáguila²,

Uberos‐Fernández³

et al. 2007

Horm Res Paediatr

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“…Wetterberg et al [6]assumed a genetic determination, possibly on the level of the enzymes involved in melatonin synthesis. They discussed a constitutional polymorphism of N-acetyltransferase (NAT) and/or hydroxyindole-O-methyltransferase (HIOMT) and speculated that individually low or high melatonin excretion may reflect a genetically determined predisposition for variable levels of noradrenergic secretory drive and/or variable NAT/HIOMT enzymatic activity during the night.…”

Section: Discussionmentioning

confidence: 99%

“…The timing and amplitude vary however considerably between individuals [2, 3, 4]. Some authors assume that this variability is determined genetically [5, 6], while others suppose environmental influences operating during intrauterine life [7]. The present study examines the first hypothesis investigating correlations between the daily excretion of the major melatonin metabolite (6-hydroxymelatoninsulfate, 6-OHMS) in siblings.…”

Section: Introductionmentioning

confidence: 99%

Excretion of 6-Hydroxymelatonin Sulfate (6-OHMS) in Siblings during Childhood and Adolescence

2003

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The analysis was performed to support the assumption that in inter-individual variations melatonin production is determined genetically. Sixty-six siblings from 31 families (27 girls, 39 boys, 3–18 years) contributed to this study with 3 to 15 urine samples collected once a year over 24 h. The samples were stored at –20°C and analyzed for the daily output of the melatonin metabolite 6-hydroxymelatonin sulfate (6-OHMS) by an enzyme-linked immunosorbent assay (ELISA). The results indicate that 6-OHMS excretion was significantly correlated in siblings (r = 0.37, p = 0.01), suggesting a possible genetic background of melatonin production. However, prospective studies controlling also lifestyle factors such as diet are required to further confirm the hypothesis.

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“…Timing and amount of synthesis are in the same individual and in a synchronized environment highly reproducible but vary considerably between individuals [1, 2]. Some authors assume that this variability is determined genetically [3], others suppose a decisive influence of environmental factors operating during intrauterine life. To determine a possible prenatal origin, Kennaway et al [4]related overnight urinary excretion of the melatonin metabolite 6-sulfatoxymelatonin (aMT.6S) of 159 adults aged 20 years to birth variable data and found significant correlations with the ponderal index at birth.…”

Section: Introductionmentioning

confidence: 99%

Do Birth Variable Data Predict Melatonin Production in 8- to 9-Year-Old Children? Analysis of Excreted 6-Sulfatoxymelatonin

Griefahn

Blaszkewicz²,

Bröde³

2004

Horm Res Paediatr

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Hypotheses: A cross-sectional study on urinary excretion of 6-sulfatoxymelatonin (aMT.6S) in young adults suggests a relation between melatonin production and body size at birth. As individual melatonin production remains stable during childhood and adolescence, this melatonin-birth size relation should also exist in children. Methods: Daily urinary output of aMT.6S of 147 healthy white children (78 boys, 69 girls), 8 or 9 years of age, was quantified by ELISA and related to birth variable data. Results: Contrary to expectation, aMT.6S output was not related to the ponderal index at birth but a moderate positive association with body mass index at the age of 8–9 years was seen. Conclusion: This study in children contradicts previous findings in adults. As no obvious reason can be identified for this discrepancy, further research (particularly a longitudinal study) is recommended to clarify whether birth variable data may predict melatonin production in certain circumstances during or after puberty.

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Normative melatonin excretion: a multinational study

Cited by 65 publications

References 72 publications

Longitudinal Study of the Simultaneous Secretion of Melatonin and Leptin during Normal Puberty

Longitudinal Study of the Simultaneous Secretion of Melatonin and Leptin during Normal Puberty

Excretion of 6-Hydroxymelatonin Sulfate (6-OHMS) in Siblings during Childhood and Adolescence

Do Birth Variable Data Predict Melatonin Production in 8- to 9-Year-Old Children? Analysis of Excreted 6-Sulfatoxymelatonin

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