Normative database of postural sway measures using inertial sensors in typically developing children and young adults

Voss, Stephanie; Zampieri, Cris; Biskis, Alexandras; Armijo, Nicholas; Purcell, Nicollette; Ouyang, Bo; Liu, Yuanqing; Berry‐Kravis, Elizabeth; O’Keefe, Joan A.

doi:10.1016/j.gaitpost.2021.07.014

Cited by 8 publications

(5 citation statements)

References 24 publications

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“…Another limitation is the age of our youngest participants. While the OPAL variables have shown validity in a cohort of approximately 200 children as young as 5 years of age, 35,36 the validity of SARA testing has not been established in participants younger than 8 years of age; we therefore are conservative in our conclusions, although this is the only clinical ataxia measure available for children 37 . All participants had typical cognitive ability and no difficulty following the instructions.…”

Section: Discussionmentioning

confidence: 93%

Wearable sensors detect impaired gait and coordination in LBSL during remote assessments

Fine

Kaufman

Goodman

et al. 2022

Ann Clin Transl Neurol

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Background Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) is a rare leukodystrophy with motor impairment due to biallelic mutations in DARS2, which encodes mitochondrial aspartyl tRNA synthetase. Progressive ataxia is the primary feature. Objective The study objective is to determine the feasibility of remotely collecting quantitative gait and balance measures in LBSL. Methods The study design uses wearable accelerometers and the scale for the assessment and rating of ataxia (SARA) scale to assess gait and postural sway in LBSL and control participants' homes through video conferencing. Results Lateral step variability (LSV), which indicates stride variability, and elevation of the step at mid‐swing are increased for LBSL patients during brief walking tests. During stance with the eyes closed, LBSL participants show rapid accelerations and decelerations of body movement covering a large sway area and path. Both the LSV and sway area during stance with the feet together and eyes closed correlate strongly with the SARA. Conclusions Wearable accelerometers are valid and sensitive for detecting ataxia in LBSL patients during remote assessments. The finding of large increases in the sway area during stance with the eyes closed is intriguing since dorsal column dysfunction is universally seen in LBSL. This approach can be applied to related rare diseases that feature ataxia.

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Section: Discussionmentioning

confidence: 93%

Wearable sensors detect impaired gait and coordination in LBSL during remote assessments

Fine

Kaufman

Goodman

et al. 2022

Ann Clin Transl Neurol

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“…The relevance of the issue goes well beyond the investigation of the understudied mechanisms contributing to the process of adaptation of standing balance (1,(8)(9)(10), and covers other areas. Whether or not adaptation can be a model for addressing balance problems in clinical populations, one can often encounter largely diverging measures of Path Length (or velocity) and Sway Area across populations of people of different ages (11)(12)(13) or with balance problems, independently of the adaptation process.…”

Section: Introductionmentioning

confidence: 99%

Incongruity of Geometric and Spectral Markers in the Assessment of Body Sway

Sozzi

Ghai²,

Schieppati

2022

Front. Neurol.

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Different measurements of body oscillations in the time or frequency domain are being employed as markers of gait and balance abnormalities. This study investigates basic relationships within and between geometric and spectral measures in a population of young adult subjects. Twenty healthy subjects stood with parallel feet on a force platform with and without a foam pad. Adaptation effects to prolonged stance were assessed by comparing the first and last of a series of eight successive trials. Centre of Foot Pressure (CoP) excursions were recorded with Eyes Closed (EC) and Open (EO) for 90s. Geometric measures (Sway Area, Path Length), standard deviation (SD) of the excursions, and spectral measure (mean power Spectrum Level and Median Frequency), along the medio-lateral (ML) and antero-posterior (AP) direction were computed. Sway Area was more strongly associated than Path Length with CoP SD and, consequently, with mean Spectrum Level for both ML and AP, and both visual and surface conditions. The squared-SD directly specified the mean power Spectrum Level of CoP excursions (ML and AP) in all conditions. Median Frequency was hardly related to Spectrum Level. Adaptation had a confounding effect, whereby equal values of Sway Area, Path Length, and Spectrum Level corresponded to different Median Frequency values. Mean Spectrum Level and SDs of the time series of CoP ML and AP excursions convey the same meaning and bear an acceptable correspondence with Sway Area values. Shifts in Median Frequency values represent important indications of neuromuscular control of stance and of the effects of vision, support conditions, and adaptation. The Romberg Quotient EC/EO for a given variable is contingent on the compliance of the base of support and adaptation, and different between Sway Area and Path Length, but similar between Sway Area and Spectrum Level (AP and ML). These measures must be taken with caution in clinical studies, and considered together in order to get a reliable indication of overall body sway, of modifications by sensory and standing condition, and of changes with ageing, medical conditions and rehabilitation treatment. However, distinct measures shed light on the discrete mechanisms and complex processes underpinning the maintenance of stance.

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“…the third derivative of position [42], has been used to quantify postural balance in quiet stance in both Parkinson's disease patients [43] and Huntington's disease patients [44], where it was able to distinguish between healthy and affected subjects. Furthermore, a recent study showed that the jerk in quiet stance decreased with age for subjects from five years old to adulthood [40]. This metric has thus far not been used to assess early sitting development in children.…”

Section: B Related Workmentioning

confidence: 99%

Quantification of the development of trunk control in healthy infants using inertial measurement units

Blok¹,

Poggensee²,

Lemus³

et al. 2022

2022 International Conference on Rehabilitation Robotics (ICORR)

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I would like to start by thanking my supervisors, dr. Daniel Lemus Perez, dr. Herwin Horemans, dr. Manon Kok and prof. dr.-ing Heike Vallery. I have enjoyed working with all off you and thoroughly appreciate your guidance throughout this process. You have helped me to perform better and I could not have come this far without your input and feedback. I would also like to thank all clinicians that have provided input during this process, but I would specifically like to thank dr. Robert Pangalila and AIOS Jolien Deferme for their continued involvement.Of course, there have also been many non-scientific contributions that brought me here. First and foremost, I would like to thank my family, Mees, and Maaike (my unofficial family), without whom I would not be where I am today. They have always believed in me and my abilities and have provided me with unconditional support. I also owe a huge thanks to my roommates, both in Delft and in The Hague, for being my personal cheerleaders, putting up with me when I was stressed and being there for me through it all. Of course, I cannot leave out my study buddies and friends. Working together and hanging out together has made the last years so much more fun, whether we were struggling together in the masterraum, enjoying extravagant lunches at the MBP office or even working together through Zoom.

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Normative database of postural sway measures using inertial sensors in typically developing children and young adults

Cited by 8 publications

References 24 publications

Wearable sensors detect impaired gait and coordination in LBSL during remote assessments

Wearable sensors detect impaired gait and coordination in LBSL during remote assessments

Incongruity of Geometric and Spectral Markers in the Assessment of Body Sway

Quantification of the development of trunk control in healthy infants using inertial measurement units

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