Normative Data of Cognitive Assessment by Auditory P300 Event Related Potential, Montreal Cognition Assessment and Choice Reaction Time and Its Variation With Age and Gender in Uttarakhand Region of India.

Abstract

Background: Tests like auditory P300 event related potential, neuro-psychometric pen pencil Montreal Cognition Assessment Test (MOCA) and Choice reaction time have been used as indexes of cognitive function. Thus this study has been planned with the aim to evaluate cognitive ability of a normal adult to nd out normative data and its, variation with age and gender in Uttarakhand region of India. Materials and Method: This cross-sectional study was carried out in the department of Physiology of AIIMS, Rishikesh on 52 healthy with ages ranging from 20 to 40 years, equal number of male & female volunteers with the ability to understand test procedures. Following tests were performed in the given order for uniformity during 11-1 pm timing of a day: 1. Event Related Potential-P300 2. Neuro-psychometric assessment (Hindi Montreal Cognitive Assessment -HMOCA test) and 3. Choice Reaction Time. Results and Conclusion: Mean of P300 Latency is 310 ± 37.14 msec, mean of P300 Amplitude is 14 ± 7.5 uv (from Cz electrode site), mean of Montreal Score is 24.81±3.25, and mean of CRT is 584.5 ±84.06 ms in all the subjects. All the parameters are better in younger age group. All the parameters are better in male except MOCA score