Normative Data for Retinal-Layer Thickness Maps Generated by Spectral-Domain OCT in a White Population

Invernizzi, Alessandro; Pellegrini, Marco; Acquistapace, Alessandra; Benatti, Eleonora; Erba, Stefano; Cozzi, Mariano; Cigada, Mario; Viola, Francesco; Gillies, Mark C; Staurenghi, Giovanni

doi:10.1016/j.oret.2017.12.012

Cited by 61 publications

(77 citation statements)

References 33 publications

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“…The thickness values in the middle ETDRS ring for non-CRAO eyes (Fig. 1) were similar to literature values (10,11) for normal patients. Except for CMT, non-CRAO layer thicknesses showed fairly low variability, even though our "normal" patients ranged in age from 31 to 82 years of age and exhibited a number of major co-morbidity eye conditions.…”

Section: Resultssupporting

confidence: 88%

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Segmenting OCT for Detecting Drug Efficacy in CRAO

Shearer¹,

Hwang

Steinkamp

et al. 2019

Preprint

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Thinning of the inner layers of the retina occurs in patients with central retinal artery occlusion (CRAO). The mechanism for such thinning may be partially due to proteolysis by a calcium-activated protease called calpain. Calpain inhibitor SNJ-1945 ameliorated the proteolysis in a past series of model experiments. The purposes of the present retrospective study were to: 1) use segmentation analysis of optical coherence tomography (OCT) images to mathematically model the loss of specific retinal layers in CRAO patients, and 2) predict the number of patients and days of observation needed for clinical trials of SNJ-1945 inhibitor against CRAO.

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Section: Resultssupporting

confidence: 88%

“…4) Thickness measurements for 11 layers and zones in eyes not affected by CRAO eyes (Fig. 1) were similar to those in a normative data base based on 2000 eyes (10). This validated the automated segmentation analysis used in the present study.…”

Section: Discussionsupporting

confidence: 80%

Segmenting OCT for Detecting Drug Efficacy in CRAO

Shearer¹,

Hwang

Steinkamp

et al. 2019

Preprint

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“…In our study, the thickening of the central region was mainly attributed to the increase in OPL thickness, which was formed by dendrites [30]. Our result was consistent with that of a recent SD-OCT study on retinal thickness [38]. We speculate that the OPL comprises thousands of dendrites, and is more elastic than the ONL.…”

Section: Discussionsupporting

confidence: 92%

Association of macular thickness with parapapillary atrophy in myopic eyes

Piao

Guo

et al. 2020

BMC Ophthalmol

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Background: To investigate whether macular structure could be affected by axial elongation and to determine the association between macular intraretinal thickness and the microstructure of β-zone parapapillary atrophy (PPA) in myopic eyes. Methods: The study recruited 113 healthy myopic subjects (113 eyes). Images of the macula, subfoveal choroid, and optic nerve head were acquired using spectral-domain optical coherence tomography (SD-OCT). An automatic segmentation algorithm was used to segment the macular images into 7 intraretinal layers. PPA widths with and without Bruch's membrane (PPA +BM and PPA-BM , respectively) were evaluated. Linear regression analysis was performed to evaluate the association between macular intraretinal thickness and axial length and the microstructure of PPA. Results: An increase in axial length was associated with a decrease in whole macular thickness of the peripheral region and an increase in whole macular thickness of the central region. Thickness alterations of the macular intraretinal layers were most apparent in the peripheral region. A significant correlation was found between PPA-BM width and macular intraretinal layer thickness, whereas no significant correlation was found between PPA +BM width and macular intraretinal layer thickness. Moreover, both PPA +BM and PPA-BM widths significantly correlated with subfoveal choroidal thickness. Conclusions: Macular intraretinal layer thickness may be affected by PPA-BM width. These findings indicate that the microstructure of PPA should be considered when evaluating the macula in patient with myopia and glaucoma.

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“…Multilayer automatic segmentation of spectral domain optical coherence tomography (SD-OCT) images has been shown to quantify the thickness of the individual layers of the retina to a high degree of accuracy and test/retest reliability. [8][9][10] The retinal nerve fiber layer (RNFL) is of particular interest as both the origin of the optic nerve and a prominent headwater for retinal venous outflow. Correlation has been shown between RNFL thickness and RVD for patients with normal tension glaucoma.…”

mentioning

confidence: 99%

Analysis of Retinal Segmentation Changes at High Altitude With and Without Acetazolamide

Clarke

Cozzi

Imray

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Our aim was to assess retinal venous diameter and segmented retinal layer thickness variation in acute systemic hypoxia with and without acetazolamide and to relate these changes to high altitude headache (HAH), as a proxy for intracerebral pathophysiology. METHODS. A total of 20 subjects participated in a 4-day ascent to the Margherita Hut (4,559 m) on Monte Rosa in the Italian Alps. Each participant was randomized to either oral acetazolamide 250 mg twice daily or placebo. A combination of digital imaging and optical coherence tomography was used to measure retinal vessel diameter and retinal layer thickness. Clinically-assessed HAH was recorded. RESULTS. A total of 18 participants had usable digital and OCT images, with 12 developing HAH. Significant thickening was seen only in the two inner layers of the retina, the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) at P ¼ 0.012 and P ¼ 0.010, respectively, independent of acetazolamide. There was a significant positive correlation between HAH and both retinal venous diameter (T ¼ 4.953, P ¼ 0.001) and retinal artery diameter (T ¼ 2.865, P ¼ 0.015), with both unaffected by acetazolamide (F ¼ 0.439, P ¼ 0.518). CONCLUSIONS. Retinal venous diameter correlates positively with HAH, adding further evidence for the proposed venous outflow limitation mechanism. The inner layers of the retina swelled disproportionately when compared to the outer layers under conditions of systemic hypoxia. Acetazolamide does not appear to influence altitudinal changes of retinal layers and vasculature.

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Normative Data for Retinal-Layer Thickness Maps Generated by Spectral-Domain OCT in a White Population

Cited by 61 publications

References 33 publications

Segmenting OCT for Detecting Drug Efficacy in CRAO

Segmenting OCT for Detecting Drug Efficacy in CRAO

Association of macular thickness with parapapillary atrophy in myopic eyes

Analysis of Retinal Segmentation Changes at High Altitude With and Without Acetazolamide

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