Normative data for optical coherence tomography in children: a systematic review

Banc, Ana; Ungureanu, Marius

doi:10.1038/s41433-020-01177-3

Cited by 24 publications

(44 citation statements)

References 86 publications

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“…Furthermore, although normative en face OCTA data have been reported 18 , 19 , this is the first reference report on volume-rendered OCTA vessel surface area values to date: the mean overall vessel surface area was 54.43 mm 2 for a retinal optical specimen measuring approximately 2.25 mm 3 . For the participants, the width of range from minimum to maximum varies up to 56% for males and up to 38% for females.…”

Section: Discussionmentioning

confidence: 85%

Reference database of total retinal vessel surface area derived from volume-rendered optical coherence tomography angiography

Maloca

Feu-Basilio

Schottenhamml

et al. 2022

Sci Rep

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Optical coherence tomography angiography (OCTA) enables three-dimensional, high-resolution, depth-resolved flow to be distinguished from non-vessel tissue signals in the retina. Thus, it enables the quantification of the 3D surface area of the retinal vessel signal. Despite the widespread use of OCTA, no representative spatially rendered reference vessel surface area data are published. In this study, the OCTA vessel surface areas in 203 eyes of 107 healthy participants were measured in the 3D domain. A Generalized Linear Model (GLM) model analysis was performed to investigate the effects of sex, age, spherical equivalent, axial length, and visual acuity on the OCTA vessel surface area. The mean overall vessel surface area was 54.53 mm2 (range from 27.03 to 88.7 mm2). OCTA vessel surface area was slightly negatively correlated with age. However, the GLM model analysis identified axial length as having the strongest effect on OCTA vessel surface area. No significant correlations were found for sex or between left and right eyes. This is the first study to characterize three-dimensional vascular parameters in a population based on OCTA with respect to the vessel surface area.

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Section: Discussionmentioning

confidence: 85%

Reference database of total retinal vessel surface area derived from volume-rendered optical coherence tomography angiography

Maloca

Feu-Basilio

Schottenhamml

et al. 2022

Sci Rep

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“…Some studies suggest differences between Caucasian, Black and Asian populations [13,15,24,30]. Such differences between ethnicities could not be analysed in our study since all children were…”

Section: Discussionmentioning

confidence: 92%

“…Within previous studies, different OCT protocols have been used or are sometimes not precisely described which may lead to different results [3,9,13]. Comparability of the data is thus limited due to a lack of precise information of the machine used, the areas analysed or the diameters of the sectors [13].…”

Section: Discussionmentioning

confidence: 99%

“…The evolution of retinal thickness during childhood is so far unclear. Previous studies have only examined standard OCT measures (peripapillary RNFL (pRNFL) and/or macular volume/thickness) in healthy children with varying OCT techniques [8][9][10][11][12][13]. Only one study describes normative values for different retinal layers after segmentation, yet, using a custom-made software and may thus be di cult to transfer to other devices [14].…”

Section: Introductionmentioning

confidence: 99%

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Retinal Layer Segmentation In A Cohort Of Healthy Children Via Optical Coherence Tomography

Runge

Remlinger

Abegg

et al. 2022

Preprint

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Background: High-resolution optical coherence tomography (OCT) allows the detection of macular pathology and involvement of the optic nerve in a wide spectrum of diseases. For the differentiation of diseased and healthy status, normal values of retinal layer segmentation are critical. Yet, normative values mostly cover adult populations with only sparse data for paediatric cohorts. We present data of retinal layer characteristics via OCT in a healthy paediatric cohort.Methods: This prospective cross-sectional study screened 75 healthy children (male=42, female=33, range 4-17 years) without visual problems. OCT was performed with a peripapillary ring and macula scan protocol to determine paediatric normative values for routine parameters (peripapillary retinal nerve fibre layer thickness (pRNFL), total macular volume (TMV), macular retinal thickness (RT)). The macula scan (6mm grid) was segmented using the device-inherent automated segmentation software (Heidelberg Eye Explorer) for retinal layers: RNFL, ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL) in 9 segments each and mean of the 9 segments.Results: We obtained OCT data of 72 children with mean age 12.49 years (standard deviation, SD, 2.18; minimum 3.93). Mean global pRNFL was 102.20 μm (SD 8.24), mean TMV 8.81 mm3 (0.30) and mean RT (all segments) 318.22 μm (10.19). Segmented macular retinal layer thicknesses (mean of all segments) were: RNFL 27.67 μm (2.14), GCL 41.94 μm (2.50), IPL 34.97 μm (2.10), INL 35.18 μm (2.15), OPL 29.06 μm (2.24), ONL 68.35 μm (6.20).Conclusion: The OCT is a useful non-invasive imaging technique for the examination of the retina in children with short duration, high imaging resolution and no known adverse effects. Normative values may serve as a comparator for different neuropaediatric disorders and are first presented with this study using an up-to-date and standardized OCT imaging technique.

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“…This means that the results of OCT examination are not automatically compared with values of normal age-matched individuals, as is the case in the adult population. For the interpretation of the OCT results, one needs existing normative databases for the paediatric population [ 48 ] or compare consecutive OCT examinations. Another aspect to consider is the possible necessity to perform handheld OCT under general anaesthesia in young children.…”

Section: Discussionmentioning

confidence: 99%

The diagnostic accuracy and prognostic value of OCT for the evaluation of the visual function in children with a brain tumour: A systematic review

et al. 2021

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Purpose To systematically review the evidence on the diagnostic accuracy and prognostic value of retinal optical coherence tomography (OCT) to detect visual acuity (VA) or visual field (VF) loss in children with a brain tumour. Methods PubMed, Embase and Cochrane Library databases were searched from inception to February 2021. We included studies evaluating retinal OCT and standard visual function parameters (VA and or VF) in children with a brain tumour. Two authors independently extracted data from each included study. They also assessed the methodological quality of the studies using the QUADAS-2 or QUIPS tool. The diagnostic accuracy of OCT was evaluated with receiver operating characteristic analysis, sensitivity, specificity, positive predictive value and negative predictive value. The prognostic value of OCT was evaluated with predictive measures (odds ratio). Results We included five diagnostic studies, with a total of 186 patients, all diagnosed with optic pathway glioma. No prognostic studies were eligible for inclusion. Included studies evaluated either retinal nerve fiber layer (RNFL) thickness or ganglion cell layer—inner plexiform layer (GCL-IPL) thickness. There was considerable heterogeneity between OCT devices, OCT protocols, visual function parameters and threshold values. Sensitivity and specificity for RNFL thickness measurement ranged from 60.0% to 100.0% and 76.6% to 100%, respectively. For GCL-IPL thickness measurement, area under the curve ranged from 0.91 to 0.98 for different diameters. Conclusion The literature regarding the diagnostic accuracy and prognostic value of OCT parameters in children with a brain tumour is scarce. Due to heterogeneity and a considerable risk of bias of included studies, we cannot draw solid conclusions regarding the accuracy of retinal OCT. Future research should investigate the potential of OCT as diagnostic and prognostic tool for the evaluation of the visual function and detection of visual impairment in children with any type of brain tumour.

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Normative data for optical coherence tomography in children: a systematic review

Cited by 24 publications

References 86 publications

Reference database of total retinal vessel surface area derived from volume-rendered optical coherence tomography angiography

Reference database of total retinal vessel surface area derived from volume-rendered optical coherence tomography angiography

Retinal Layer Segmentation In A Cohort Of Healthy Children Via Optical Coherence Tomography

The diagnostic accuracy and prognostic value of OCT for the evaluation of the visual function in children with a brain tumour: A systematic review

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