Normative data for functional assessment of cancer therapy General scale and its use for the interpretation of quality of life scores in cancer survivors

Holzner, Bernhard; Kemmler, Georg; Cella, David; Paoli, Christina De; Meraner, Verena; Kopp, Martin; Greil, Richard; Fleischhacker, W. Wolfgang; Sperner‐Unterweger, Barbara

doi:10.1080/02841860310023453

Cited by 112 publications

(112 citation statements)

References 30 publications

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“…From the 19 included studies, multiple symptoms that were influenced by gender were identified including: emotion, pain, fatigue and many others. Although specific influences of a gender on emotions or changes in emotions experienced by advanced cancer patients was contradictory, there is strong evidence that in general, gender does influence the emotion of patients as demonstrated by Holzner et al in a general population using the Fact-G [10,11,26]. This difference in the general population, however, was less pronounced than in the advanced cancer population identified by Zimmerman et al [11,26].…”

Section: Discussionmentioning

confidence: 49%

“…Although specific influences of a gender on emotions or changes in emotions experienced by advanced cancer patients was contradictory, there is strong evidence that in general, gender does influence the emotion of patients as demonstrated by Holzner et al in a general population using the Fact-G [10,11,26]. This difference in the general population, however, was less pronounced than in the advanced cancer population identified by Zimmerman et al [11,26]. Such gender differences in emotional moods within the advanced cancer patient population may be associated with psychological factors such as the denial of the diagnosis of advanced cancer [10].…”

Section: Discussionmentioning

confidence: 99%

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Gender differences in symptoms experienced by advanced cancer patients: a literature review

Wong

Bedard

Pulenzas

et al. 2013

RHC

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INTRODUCTION: Advanced cancer patients are multi-symptomatic and require attentive palliative care. As gender differences are apparent in multiple aspects of everyday life, this literature review aims to determine the gender differences seen in the population of advanced cancer patients and the symptoms that they experience. METHODS: A literature review was conducted using the OvidSP Medline database from 1946 to November 2012. Randomized, prospective or retrospective cohort studies on advanced cancer patients who were undergoing any type of palliative treatments (palliative radiation, chemotherapy) or those in which palliative treatments have failed (antalgic treatment) were included. The patient population, tools/questionnaire used and gender differences in symptoms found statistically or qualitatively significant in the respective studies were extracted. RESULTS: Of the 163 studies resulting from the literature search, nineteen publications were identified. Gender differences in multiple symptoms were discovered. Gender differences were commonly found in symptoms of emotional changes, fatigue, gastrointestinal symptoms (nausea, vomiting, and diarrhea) anxiety, tension, sleep problems and pain. CONCLUSION: At present, gender differences seen in the symptoms experienced by advanced cancer patients continues to be inconclusive. Further study investigating gender differences in the symptoms experienced by advanced cancer patients as the primary endpoint is recommended.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Gender differences in symptoms experienced by advanced cancer patients: a literature review

Wong

Bedard

Pulenzas

et al. 2013

RHC

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“…The sampling procedure of the general population sample is described in more detail elsewhere. 7 Assessment instruments EORTC QLQ-C30. The EORTC QLQ-C30, 8 an internationally validated and widely used cancer-specific QOL instrument, assesses various facets of functioning, symptoms common in cancer patients as well as global QOL.…”

Section: Aimsmentioning

confidence: 99%

Impact of GvHD on quality of life in long-term survivors of haematopoietic transplantation

Pallua

Giesinger

Oberguggenberger

et al. 2010

Bone Marrow Transplant

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Allogenic haematopoietic stem cell transplantation (HCT) has become an effective therapy in patients with various haematological malignancies. GvHD is known to be a major complication in this patient group and is assumed to have a major impact on patients' quality of life (QOL). Patients after BMT or transplantation of mobilized PBSCs were considered for enrolment in the study 6 months after transplantation. QOL and symptom burden were assessed using the EORTC QLQ-C30 and the QLQ-HDC29. Data from age-and sex-matched healthy controls were collected for comparison. In all, 100 patients (55.0% women; mean age 46.3 years) after allogeneic HCT were included in the study. In this patient group, we found a clinically relevant impact of GvHD on role functioning, global QOL, fatigue, dyspnoea, gastrointestinal side effects, worries/anxiety and skin problems. In comparison to healthy controls, various aspects of QOL were severely impaired. Our study revealed severe impairments of QOL in survivors of HCT, in particular in those suffering from GvHD. Taking into account, that the prevalence of GvHD might be higher in patients after PBSCT compared with patients after BMT, PBSCT is expected to lead to more severe impairments of QOL than BMT.

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“…Although many studies on QOL of patients with cancer before and after treatment have been reported, they differ greatly in results: Most studies demonstrated that patients' QOL decreases after treatment, some reported no significant difference in the QOL of patients with esophageal cancer before and after treatment, or even some reports claimed that patients' QOL is stabilized or improved after treatment (Carter et Greimel et al, 2002). These inconsistent results are presumably correlated with differences in subjects' tumor positions and perspectives taken in different researches (Holzner et al, 2004). Nowadays, study on the influencing factors of EC patients' QOL is still in infancy, and most researches have only focused on social support and economic status.…”

Section: Discussionmentioning

confidence: 99%

Influence of Personal Character on Quality of Life of Patients with Esophageal Cancer in North Henan Province and Influencing Factors

Lin

Mingsheng²,

Liu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The aim of this study was to investigate QoL (quality of life) of patients with esophageal cancer in northern Henan province, China, and to accurate evaluate and reflect the relationship between patient characteristics and QoL. In the high risk area of esophageal cancer in the north of Henan province, 735 patients with esophageal cancer were investigated. The Eysenck personality questionnaire (EPQ) and QoL were analyzed by using the questionnaire of general situation, EPQ, QLQ-C30 and QLQ-OES18. The effects of personal character on the QoL of esophageal carcinoma patients were analyzed by SPSS 11.0 software. The QoL of esophageal cancer patients in Northern Henan region was significantly affected by character. The difference between choleric and type of melancholic temperament types was significant (P<0.01), also in OESEAT, OESTA, OESCO and OESSP (P<0.05). Differences in personal character can thus influence the quality of esophageal cancer patient lives.

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Normative data for functional assessment of cancer therapy General scale and its use for the interpretation of quality of life scores in cancer survivors

Cited by 112 publications

References 30 publications

Gender differences in symptoms experienced by advanced cancer patients: a literature review

Gender differences in symptoms experienced by advanced cancer patients: a literature review

Impact of GvHD on quality of life in long-term survivors of haematopoietic transplantation

Influence of Personal Character on Quality of Life of Patients with Esophageal Cancer in North Henan Province and Influencing Factors

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