Normative data assessment of age-related changes in macular and optic nerve head vessel density using optical coherence tomography angiography

Abay, Rafiye Nur; Akdeniz, Günhal Şatırtav; Katipoğlu, Zeynep; Kerimoğlu, Hürkan

doi:10.1016/j.pdpdt.2021.102624

Cited by 14 publications

(7 citation statements)

References 25 publications

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“…Even in the thinner choroid, the VD was more in our subjects than that seen by Maruko et al [22]. With the increase in age, the VD in the SCP and DCP and CC flow area significantly reduced but the FAZ area increased though this increase was not statistically significant (p=0.660) [23].…”

Section: Discussioncontrasting

confidence: 62%

“…Abay et al studied 153 eyes of 153 healthy individuals aged between 20 and 80 years in 6 x 6 mm retinal OCTA images for SCP VD, DCP VD, FAZ area and CC flow area and compared these values among five age groups. With the increase in age, the VD in the SCP and DCP and CC flow area significantly reduced but the FAZ area increased though this increase was not statistically significant (p=0.660) [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

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Evaluating the Quantitative Foveal Avascular Zone and Retino-Choroidal Vessel Density Using Optical Coherence Tomography Angiography in a Healthy Indian Population

Sodhi¹,

Shaw²,

Gautam³

et al. 2022

Cureus

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Objective: The foveal avascular zone (FAZ) is the round capillary-free zone within the macula and is supplied only by a single-layered parafoveal capillary arcade. This study aimed to evaluate the quantitative FAZ and retino-choroidal vessel density (VD) using optical coherence tomography angiography (OCTA) in a healthy Indian population.Methods: This was a cross-sectional observational study that was conducted for evaluating the quantitative FAZ and retino-choroidal VD of 200 eyes of 100 healthy Indian subjects, including 62 males and 38 females (age range 17-50 years) having the best-corrected visual acuity (BCVA) of logMAR 0 (20/20; 6/6) and spherical equivalent refractive error of not more than 1 D. The subjects were examined using OCTA automated software on spectral-domain OCT (SD-OCT; Nidek RS 3000 Advance 2; Nidek, Inc., Fremont, CA) on a 3 x 3 mm OCTA macular scan centred on the fovea. The FAZ size, perimeter and circularity index, VD in superficial, deep, and outer retina (OR), outer retinal chorio-capillaries (ORCC), chorio-capillaries (CC) and choroid (C) were analysed in the circular and quadrant-segmented zones. A correlation was found between the FAZ size, perimeter and circularity, and VD in retino-choroidal layers, and between BCVA, age, central foveal thickness (CFT) and sub-foveal choroidal thickness (SFCT), and OCTA parameters.Results: The FAZ and surrounding vascular arcades were intact in all eyes, showing either a vertical or horizontal oval-shaped symmetrical formation without gaps, holes or interruption of the capillary network. The mean value of CFT was 237.5±26.0 microns and SFCT was 269.6±53.0 microns. The mean FAZ area was 0.42±0.23 mm 2 , FAZ perimeter was 3.3±1.0 mm and FAZ circularity index was 0.46±0.1. The mean VD in superficial capillary plexus (SCP) was 23.87±10.66, in deep capillary plexus (DCP) was 16.03±9.90, in OR was 13.22± 12.27, in ORCC was 39.74±14.32, in CC was 37.02±16.43 and in choroid was 37.43±16.76. The increasing order of VD in different retino-choroidal layers was OR

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Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Evaluating the Quantitative Foveal Avascular Zone and Retino-Choroidal Vessel Density Using Optical Coherence Tomography Angiography in a Healthy Indian Population

Sodhi¹,

Shaw²,

Gautam³

et al. 2022

Cureus

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“…Although there was an upward trend in retinal capillary plexus vessel density before the age of 35–40 years, the difference was small and not statistically significant. This is consistent with the results from Abay et al’s study [ 20 ]. Age-related decrease in retinal capillary plexus vessel density may be related to age-related retinal capillary occlusion and atrophy [ 21 ].…”

Section: Discussionsupporting

confidence: 94%

Age- and sex-related differences in the retinal capillary plexus in healthy Chinese adults

Zhu

Yang

et al. 2022

Eye and Vis

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Background To assess age- and sex-related changes in the superficial retinal capillary plexus (SCP) and deep retinal capillary plexus (DCP) in healthy Chinese adults. Methods In this cross-sectional study, all data were derived from the community-based Jidong Eye Cohort Study. Participants underwent optical coherence tomography angiography (OCTA) and other ocular and systemic examinations. The vessel densities of the whole measured area, parafovea, and four quadrants in the SCP and DCP were measured. Results We recruited 1036 eyes of 1036 healthy participants; the mean age was 40.4 ± 9.8 years, and 449 (43.3%) participants were males. The SCP and DCP vessel densities in all regions, except for temporal and nasal regions in the SCP, non-linearly decreased with age. The DCP vessel densities began to decrease at approximately 35 years of age, while the SCP vessel densities began to decrease at approximately 40 years of age. The DCP vessel densities decreased more rapidly than the SCP vessel densities at 35–50 years of age. The DCP vessel densities remained stable or slightly decreased after the age of 50 years in females, while those decreased linearly in most regions in males. Conclusions The retinal vessel density decreased earlier and more rapidly in the DCP than in the SCP, and the effect of aging on the DCP vessel density was sex-dependent. Our findings suggest that age and sex should be considered when interpreting clinical quantitative OCTA data.

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“…Karahan et al ( 24 ) found changes only in the deep FAZ area in patients with MA. These results suggest that there are individual differences in the FAZ size, which are closely related to various factors such as the macular central recess structure, eye axis length, age, race, and gender ( 41 ).…”

Section: Discussionmentioning

confidence: 93%

Retina and microvascular alterations in migraine: a systemic review and meta-analysis

Liu,

Jie,

Wang

et al. 2023

Front. Neurol.

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ObjectiveThis study aimed to evaluate the retina and microvascular alterations with optical coherence tomography (OCT) or optical coherence tomography angiography (OCTA) in patients with migraine with aura (MA) and migraine without aura (MO).MethodsPubMed, Embase, and Cochrane Library databases were searched to find relevant literature on patients with MA or MO using OCT/OCTA devices. The eligible data were analyzed by Stata Software (version 15.0).ResultsThere were 16 studies identified, involving 379 eyes with MA, 583 eyes with MO, and 658 eyes of healthy controls. The thickness of the peripapillary retinal nerve fiber layer (pRNFL) of patients with MA decreased significantly in most regions. The foveal avascular zone (FAZ) area and perimeter in MA patients significantly enlarged, while the perfusion density (PD) in the macular deep capillary plexus (mDCP) significantly decreased in the whole image and its subregions except for the fovea, with the PD in radial peripapillary capillary (RPC) decreasing inside the disk. Patients with MO demonstrated a significantly decreased thickness of pRNFL in most regions, and the FAZ parameters were significantly enlarged. No statistical significance was observed in the retina and microvascular features of patients with MA and MO.ConclusionThe eyes affected by MA and MO demonstrated significantly reduced thickness of pRNFL and enlarged FAZ. Patients with MA showed retinal microvascular impairments, including a decreased PD in mDCP. The OCT and OCTA could detect membrane morphology and circulation status in migraine and might provide the basis for the diagnosis and follow-up of patients with migraine.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, CRD42023397653.

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Normative data assessment of age-related changes in macular and optic nerve head vessel density using optical coherence tomography angiography

Cited by 14 publications

References 25 publications

Evaluating the Quantitative Foveal Avascular Zone and Retino-Choroidal Vessel Density Using Optical Coherence Tomography Angiography in a Healthy Indian Population

Evaluating the Quantitative Foveal Avascular Zone and Retino-Choroidal Vessel Density Using Optical Coherence Tomography Angiography in a Healthy Indian Population

Age- and sex-related differences in the retinal capillary plexus in healthy Chinese adults

Retina and microvascular alterations in migraine: a systemic review and meta-analysis

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