2019
DOI: 10.3389/fneur.2019.01117
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Normative Data and Minimally Detectable Change for Inner Retinal Layer Thicknesses Using a Semi-automated OCT Image Segmentation Pipeline

Abstract: Neurodegenerative and neuroinflammatory diseases regularly cause optic nerve and retinal damage. Evaluating retinal changes using optical coherence tomography (OCT) in diseases like multiple sclerosis has thus become increasingly relevant. However, intraretinal segmentation, a necessary step for interpreting retinal changes in the context of these diseases, is not standardized and often requires manual correction. Here we present a semi-automatic intraretinal layer segmentation pipeline and establish normative… Show more

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Cited by 39 publications
(51 citation statements)
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References 46 publications
(61 reference statements)
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“…OCT data are compared with our suggested method in terms of "simplicity and availability", whereas the Livelayer's ability to segment different types of OCTs was argued in the previous sections of this study. OCTMarker [20] is an integrated software package that could only detect up to 3 retinal boundaries automatically. EdgeSelect [16] and SAMIRIX [20] Including an error correction functionality…”
Section: Conclusion and Discussionmentioning
confidence: 99%
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“…OCT data are compared with our suggested method in terms of "simplicity and availability", whereas the Livelayer's ability to segment different types of OCTs was argued in the previous sections of this study. OCTMarker [20] is an integrated software package that could only detect up to 3 retinal boundaries automatically. EdgeSelect [16] and SAMIRIX [20] Including an error correction functionality…”
Section: Conclusion and Discussionmentioning
confidence: 99%
“…OCTMarker [20] is an integrated software package that could only detect up to 3 retinal boundaries automatically. EdgeSelect [16] and SAMIRIX [20] Including an error correction functionality…”
Section: Conclusion and Discussionmentioning
confidence: 99%
“… Flow chart explaining the overall study design and information technology (IT) infrastructure. DCC, Data Coordinating Center; OCT, optical coherence tomography; REDCap, Research Electronic Data Capture; SAMIRIX is a custom-developed intraretinal segmentation pipeline 55 . OSCAR-IB are validated consensus quality criteria for retinal OCT reading 53 .…”
Section: Cohort Descriptionmentioning
confidence: 99%
“…pRNFL segmentation was performed with device-internal algorithms, intraretinal layer segmentation with a device-independent segmentation pipeline. 55 …”
Section: Cohort Descriptionmentioning
confidence: 99%
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