Normalizing Biased Spatial Attention With Parietal rTMS in a Patient With Focal Hand Dystonia

Ricci, Raffaella; Salatino, Adriana; Siebner, Hartwig R.; Mazzeo, Gaetano; Nobili, Marcello

doi:10.1016/j.brs.2014.07.038

Cited by 17 publications

(18 citation statements)

References 8 publications

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“…Indeed the PPC plays a crucial role in line bisection performance together with the cerebellum (Fink et al, 2000;Ricci et al, 2012;Salatino, Poncini, George, & Ricci, 2014;Thiebaut de Schotten et al, 2011). Consistent with the above hypothesis, inhibitory rTMS over PPC, contralateral to the dystonic hand, improved the attentional bias (Ricci et al, 2014(Ricci et al, , 2015.…”

Section: Introductionmentioning

confidence: 79%

“…However, they used complex tasks and do not provide information on the presence of a specific directional bias (i.e., toward or opposite to the affected side) and/or evidence of a relationship with specific forms of CD. Some more recent preliminary evidence, in patients with a different form of focal dystonia (i.e., affecting the upper and/or lower limb) showed biased visuospatial attention toward the side of the dystonic muscles using a simple line bisection task (Ricci, Salatino, Siebner, Mazzeo, Nobili, 2014;Ricci, Mazzeo, Celentano, Nobili, & Salatino. 2015).…”

Section: Introductionmentioning

confidence: 99%

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Biased Visuospatial Attention in Cervical Dystonia

Chillemi

Formica

Salatino

et al. 2017

J Int Neuropsychol Soc

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Section: Introductionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Biased Visuospatial Attention in Cervical Dystonia

Chillemi

Formica

Salatino

et al. 2017

J Int Neuropsychol Soc

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“…Furthermore, abnormal connectivity between PPC and primary motor cortex (M1) may be present in CD, an abnormality that is associated with slower reaching movements (49, 50). The interaction between PPC and M1 is crucial for the preparation and planning of movements directed to visual targets (51, 52), as it regulates visuo-spatial mechanisms that affect performance, accuracy, and variability.…”

Section: Discussionmentioning

confidence: 99%

Spatial and Temporal High Processing of Visual and Auditory Stimuli in Cervical Dystonia

et al. 2017

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ObjectiveInvestigation of spatial and temporal cognitive processing in idiopathic cervical dystonia (CD) by means of specific tasks based on perception in time and space domains of visual and auditory stimuli.BackgroundPrevious psychophysiological studies have investigated temporal and spatial characteristics of neural processing of sensory stimuli (mainly somatosensorial and visual), whereas the definition of such processing at higher cognitive level has not been sufficiently addressed. The impairment of time and space processing is likely driven by basal ganglia dysfunction. However, other cortical and subcortical areas, including cerebellum, may also be involved.MethodsWe tested 21 subjects with CD and 22 age-matched healthy controls with 4 recognition tasks exploring visuo-spatial, audio-spatial, visuo-temporal, and audio-temporal processing. Dystonic subjects were subdivided in three groups according to the head movement pattern type (lateral: Laterocollis, rotation: Torticollis) as well as the presence of tremor (Tremor).ResultsWe found significant alteration of spatial processing in Laterocollis subgroup compared to controls, whereas impairment of temporal processing was observed in Torticollis subgroup compared to controls.ConclusionOur results suggest that dystonia is associated with a dysfunction of temporal and spatial processing for visual and auditory stimuli that could underlie the well-known abnormalities in sequence learning. Moreover, we suggest that different movement pattern type might lead to different dysfunctions at cognitive level within dystonic population.

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“…Therefore we cannot draw a firm conclusion that ACC is not a potential therapeutic site, especially if an alternative coil was used for the targeting. Our choice of targets was based on previous studies that had been shown to be potentially therapeutic in focal dystonia; however, a recent case report described a new potential site, the left posterior parietal cortex, which was not examined in this study [ 16 ]. Remote targeting is another potential avenue of therapy to explore.…”

Section: Discussionmentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation in Cervical Dystonia: Effect of Site and Repetition in a Randomized Pilot Trial

2015

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Dystonia is characterized by abnormal posturing due to sustained muscle contraction, which leads to pain and significant disability. New therapeutic targets are needed in this disorder. The objective of this randomized, sham-controlled, blinded exploratory study is to identify a specific motor system target for non-invasive neuromodulation and to evaluate this target in terms of safety and tolerability in the cervical dystonia (CD) population. Eight CD subjects were given 15-minute sessions of low-frequency (0.2 Hz) repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (MC), dorsal premotor cortex (dPM), supplementary motor area (SMA), anterior cingulate cortex (ACC) and a sham condition with each session separated by at least two days. The Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) score was rated in a blinded fashion immediately pre- and post-intervention. Secondary outcomes included physiology and tolerability ratings. The mean change in TWSTRS severity score by site was 0.25 ± 1.7 (ACC), -2.9 ± 3.4 (dPM), -3.0 ± 4.8 (MC), -0.5 ± 1.1 (SHAM), and -1.5 ± 3.2 (SMA) with negative numbers indicating improvement in symptom control. TWSTRS scores decreased from Session 1 (15.1 ± 5.1) to Session 5 (11.0 ± 7.6). The treatment was tolerable and safe. Physiology data were acquired on 6 of 8 subjects and showed no change over time. These results suggest rTMS can modulate CD symptoms. Both dPM and MC are areas to be targeted in further rTMS studies. The improvement in TWSTRS scores over time with multiple rTMS sessions deserves further evaluation.Trial RegistrationClinicalTrials.gov NCT01859247

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Normalizing Biased Spatial Attention With Parietal rTMS in a Patient With Focal Hand Dystonia

Cited by 17 publications

References 8 publications

Biased Visuospatial Attention in Cervical Dystonia

Biased Visuospatial Attention in Cervical Dystonia

Spatial and Temporal High Processing of Visual and Auditory Stimuli in Cervical Dystonia

Repetitive Transcranial Magnetic Stimulation in Cervical Dystonia: Effect of Site and Repetition in a Randomized Pilot Trial

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