Normalization of ventral tegmental area structure following acupuncture in a rat model of heroin relapse

Zhang, Rongjun; Cai, Xing-Hui; Song, Xiaojing; C, Dong; Hou, Xiaorong; Lv, Lei

doi:10.4103/1673-5374.128228

Cited by 6 publications

(2 citation statements)

References 24 publications

(28 reference statements)

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“…According to the theory of TCM, the synergistic and complementary effects of different acupoints compatibility supposedly have an advantage in clinical practice to enhance the curative efficacy and reduce the side effects ( 39 ). In clinical practice, GV20 and GV14 are usually used in combination with each other ( 40 ). Previous studies demonstrated that GV20 and GV14 are optimized acupoints combinations for neuropsychiatric disorders, which could improve the cerebral blood circulation, enhance memory, and improve antidepressant activity, playing a key role in brain protection ( 41 , 42 ).…”

Section: Discussionmentioning

confidence: 99%

Metabolomics Analysis on Mice With Depression Ameliorated by Acupoint Catgut Embedding

et al. 2021

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Depression is a prevalent mental disease characterized by persistent low mood, lack of pleasure, and exhaustion. Acupoint catgut embedding (ACE) is a kind of modern acupuncture treatment, which has been widely used for the treatment of a variety of neuropsychiatric diseases. To investigate the effects and underlying mechanism of ACE on depression, in this study, we applied ACE treatment at the Baihui (GV20) and Dazhui (GV14) acupoints of corticosterone (CORT)-induced depression model mice. The results showed that ACE treatment significantly attenuated the behavioral deficits of depression model mice in the open field test (OFT), elevated-plus-maze test (EPMT), tail suspension test (TST), and forced swimming test (FST). Moreover, ACE treatment reduced the serum level of adreno-cortico-tropic-hormone (ACTH), enhanced the serum levels of 5-hydroxytryptamine (5-HT), and noradrenaline (NE). Furthermore, metabolomics analysis revealed that 23 differential metabolites in the brain of depression model mice were regulated by ACE treatment for its protective effect. These findings suggested that ACE treatment ameliorated depression-related manifestations in mice with depression through the attenuation of metabolic dysfunction in brain.

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Section: Discussionmentioning

confidence: 99%

Metabolomics Analysis on Mice With Depression Ameliorated by Acupoint Catgut Embedding

et al. 2021

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“…Transcutaneous electric acupoint stimulation was a possible adjunctive treatment to pharmacological treatments for heroin detoxification [ 62 ]. Acupuncture at Dazhui (GV14) and Baihui (DU20) prevented brain cell apoptosis in heroin-readdicted rats, normalized neuronal ultrastructure in the ventral tegmental area of heroin relapse rats, and protected nerve cells against injury in heroin relapse rats [ 32 , 88 ].…”

Section: Reviewmentioning

confidence: 99%

Acupuncture therapy for drug addiction

et al. 2016

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Acupuncture therapy has been used to treat substance abuse. This study aims to review experimental studies examining the effects of acupuncture on addiction. Research and review articles on acupuncture treatment of substance abuse published between January 2000 and September 2014 were searched using the databases ISI Web of Science Core Collection and EBSCO’s MEDLINE Complete. Clinical trial studies on the efficacy of acupuncture therapy for substance abuse were classified according to substance (cocaine, opioid, nicotine, and alcohol), and their treatment protocols, assessments, and findings were examined. A total of 119 studies were identified, of which 85 research articles addressed the efficacy of acupuncture for treating addiction. There were substantial variations in study protocols, particularly regarding treatment duration, frequency of electroacupuncture, duration of stimulation, and choice of acupoints. Contradictory results, intergroup differences, variation in sample sizes, and acupuncture placebo effects made it difficult to evaluate acupuncture effectiveness in drug addiction treatment. This review also identified a lack of rigorous study design, such as control of confounding variables by incorporating sham controls, sufficient sample sizes, reliable assessments, and adequately replicated experiments.

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The Modulation of Reward and Habit Systems by Acupuncture in Adolescents with Internet Addiction

Wang

Qin

et al. 2020

Neural Plasticity

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Purpose. Acupuncture is an effective therapy for Internet addiction (IA). However, the underlying mechanisms of acupuncture in relieving compulsive Internet use remain unknown. Neuroimaging studies have demonstrated the role of the ventral striatum (VS) in the progress of IA; hence, the aim of this study was to explore the effects of acupuncture on the resting-state functional connectivity (rsFC) and relevant network of VS in IA. Methods. Twenty-seven IA individuals and 30 demographically matched healthy control subjects (HCs) were recruited in this study. We acquired the functional magnetic resonance imaging (fMRI) data in IA subjects before and after 40 days of acupuncture treatment. Seed-to-voxel and ROI-to-ROI analyses were applied to detect the rsFC alterations of the VS and related network in IA subjects and to investigate the modulation effect of acupuncture on the rsFC. Results. Compared with HCs, IA subjects exhibited enhanced rsFC of the right ventral rostral putamen (VRP) with the left orbitofrontal cortex (OFC), premotor cortex (PMC), cerebellum, and right ventromedial prefrontal cortex (vmPFC). In the network including these five ROIs, IA also showed increased ROI-to-ROI rsFC. Using a paired t-test in IA subjects before and after 40 days of acupuncture, the increased ROI-to-ROI rsFC was decreased (normalized to HC) with acupuncture, including the rsFC of the right VRP with the left OFC, PMC, and cerebellum, and the rsFC of the left cerebellum with the left OFC, PMC, and right vmPFC. Furthermore, the change in rsFC strength between the right VRP and left cerebellum in IA individuals was found positively correlated with the Internet craving alleviation after acupuncture. Conclusions. These findings verified the modulation effect of acupuncture on functional connectivity of reward and habit systems related to the VS in IA individuals, which might partly represent the underlying mechanisms of acupuncture on IA.

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Normalization of ventral tegmental area structure following acupuncture in a rat model of heroin relapse

Cited by 6 publications

References 24 publications

Metabolomics Analysis on Mice With Depression Ameliorated by Acupoint Catgut Embedding

Metabolomics Analysis on Mice With Depression Ameliorated by Acupoint Catgut Embedding

Acupuncture therapy for drug addiction

The Modulation of Reward and Habit Systems by Acupuncture in Adolescents with Internet Addiction

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