Normalization of urinary pteridines by urine specific gravity for early cancer detection

Urinary suPAR: a non-invasive biomarker of infection and tissue inflammation for use in studies of large free-ranging mammals

“…Here, we could show that SG is not affected at all by the conditions tested whereas Cr, although being largely robust as well (see also [69,74]), was impacted by faecal contamination and storage of samples at elevated temperatures for several days. Thus, SG has clear advantages over Cr for normalizing urinary analyte concentrations, at least under suboptimal conditions of sample collection and handling, confirming results from other studies in which both measures have been compared [84,85,92].…”

“…As Cr and SG are also widely used when indexing other urinary analytes such as steroid hormones, C-peptides or neopterin [33,82,84], we also assessed the effects of the different treatments on Cr concentrations (as mg ml −1 urine) as well as on SG separately.…”

A New Diagnostic and Prognostic Marker in Endometrial Cancer: Neopterin

“…Urine neopterin levels were proportioned to creatinine and expressed as micromoles (Kmol)/mol creatinine to prevent the variability according to renal function. 18 The normal range of urine neopterin is determined as 50 to 250 Kmol/mol creatinine. endometrial cancer (group 2) were 52.8 T 12.7 and 57.9 T 9.6 years, respectively.…”

A comment to “Normalization of urinary pteridines by urine specific gravity for early cancer detection” [Clin. Chim. Acta 435 (2014) 42–47]

“…In their recent publication [1], Burton et al described a comparison of urinary levels of several pteridine derivatives normalized with respect to urine concentration by either urine specific gravity (USG) or by relation to urinary creatinine concentration. They conclude that correction of urinary pteridine concentrations by USG provides better performance of these biomarkers in early detection of cancer than creatinine-based correction.…”