Normalization of regulatory T cells, serum TGF-β1, and LTN after 5-aminolevulinic acid-photodynamic therapy in patients with condyloma acuminate

Abstract

The purpose of this study was to investigate the changes in peripheral blood regulatory T (Treg) cells, serum transforming growth factor-β1 (TGF-β1), and lymphotactin (LTN) following treatment of patients with condyloma acuminata (CA) with 5-aminolevulinic acid-photodynamic. A total of 46 patients with CA were selected as the experimental group and 43 healthy individuals were included in the control group. Before the treatment, the CA patients had a higher number of CD4+CD25+Foxp3+ Treg cells and CD4+CD25+ Treg cells than the healthy group. CA patients also had lower levels of serum TGF-β1 and LTN than the healthy controls. After the treatment, the number of CD4+CD25+Foxp3+ Treg cells and CD4+CD25+ Treg cells decreased significantly in the CA patients and normalized to the levels in the control group after 3 weeks. The treatment also elevated the levels of serum TGF-β1 and LTN in the CA patients, which were close to the values in the control group after 3 weeks. The results showed that low levels of serum TGF-β1 and LTN played important roles in the occurrence and development of CA and cellular immune functions were closely related to the occurrence and development of CA.

Correlation of miR-125b with Treg/Th17 cell imbalance in Condyloma acuminatum and its regulation on autophagy of keratinocytes

“…The elevated level of Treg cells is an important cause of immune suppression, which can inhibit the Th1/Th2 differentiation and mediate the inflammatory response and immune response of T cells (25). Therefore, as the level of Th17 cells decreases, the body's response to inflammation and chemokines is weakened (manifested as increased Treg), thus prolonging the duration of HPV infection and eventually leading to CA (26). The obvious correlation between miR-125b and Th17/Treg cells identified in our research not only reaffirms the close connection between miR-125b and CA but also supports the regulation of miR-125b on human immune function.…”

Trends and targets in antiviral phototherapy

“…248c Likewise, the connection between ALA-PDT of Condylomata acuminata and the level of regulatory T cells, serum TGF-β1, and lymphotactin has been investigated, showing that low levels of serum TGF-β1 and lymphotactin played an important role in the occurrence and development of Condylomata acuminata. 261 ALA, MAL or HAL are usually applied topically, 235,237,239,240,241,243,244,245 though an intralesional injection has been successfully tested as well. 236 The use of a high-pressure needle-free injection for this treatment has also been reported.…”

Management of Large Size Wartsasia

“…There is a significant, up to 10 fold increase of interleukin (IL)-1 alpha and a 2.5-fold increase of tumor necrosis factor-alpha [128] following photodynamic therapy (PDT). Response to therapy is associated with increase in CD8+ cells [28,128], CD4+ cells [129], dendritic cells, and decrease in Treg cells [130] with achievement of normal Treg level by three weeks. 5-aminolevulinic acid can be injected into lesion to enhance penetration and increase its effectiveness e.g larger or thicker lesions [131,132].…”