Normalization of EEG in depression after antidepressant treatment with sertraline? A preliminary report

Independent Replication and Drug-specificity of an Antidepressant Response Polygenic Risk Score

“…Follow-up analyses demonstrated a significant interaction when adding drug as a factor to the analyses, with opposing effects for escitalopram and sertraline. While sertraline is also considered a first-line SSRI, sertraline has more pronounced dopamine active transporter (DAT) inhibitory activity, is associated with increased extracellular dopamine in the nucleus accumbens, and striatum, and has anticonvulsant properties that may mediate its antidepressant response [13,18]. Thus, the current findings strengthen the notion of drug-specific associations between biological variables and outcomes in psychiatry, now also from a polygenic perspective.…”

Resting and TMS-EEG markers of treatment response in major depressive disorder: A systematic review

“…Forty-seven studies examined rEEG markers of treatment response to pharmacotherapies, brain stimulation therapies, and other therapies ( Table 1 ). These studies reported quantitative rEEG measures such as power analysis (Cook, 2002 ; Knott et al, 2002 ; Deslandes et al, 2010 ; Widge et al, 2013 ; Gollan et al, 2014 ; Jaworska et al, 2014 , p. 201; Leuchter et al, 2002 , 2017 ; Arns et al, 2014 , 2016 ; Alexander et al, 2019 ; Bailey et al, 2019 ; Cao et al, 2019 ; Cook et al, 2019 ; McMillan et al, 2020 ; Szumska et al, 2021 ), cordance (Cook, 2002 ; Leuchter et al, 2002 ; Hunter et al, 2006 , 2009 , 2010a , b ; Cook et al, 2009 ; Bares et al, 2015a ; Bailey et al, 2019 ; Cao et al, 2019 ; de la Salle et al, 2020 ), current density (Pizzagalli et al, 2001 , 2018 ; Mulert et al, 2007a , b ; Korb et al, 2009 , 2011 ; Narushima et al, 2010 ; Tenke et al, 2011 ; Hunter et al, 2013 , p. 201; Jaworska et al, 2014 ; Almeida Montes et al, 2015 ; Arns et al, 2015 ), a weighted combination of alpha and theta power compared over time (termed: antidepressant treatment response (ATR) index) (Leuchter et al, 2009a , b ; Hunter et al, 2011 ; Cook et al, 2013 ; Widge et al, 2013 ), vigilance (Olbrich et al, 2016 ; Schmidt et al, 2017 ; Sander et al, 2018 ; Ip et al, 2021 ), normalizations and abnormalities (Arns et al, 2017 ; van der Vinne et al, 2019a , b ), individualized alpha-peak frequency (iAPF) (Bailey et al,…”

“…Slow APF was associated with SSRI response only (Arns et al, 2017 ). EEG normalization was noted in SSRI but not SNRI responders (van der Vinne et al, 2019a ). Higher right-sided alpha power at baseline and after 8 weeks of SSRI was a stable marker associated with response in females, but not SNRI response (van der Vinne et al, 2019b ).…”

EEG biomarker informed prescription of antidepressants in MDD: a feasibility trial

“…We investigated 195 outpatients with non-psychotic MDD, recruited between June 2015 and July 2019 in an outpatient clinic in Leeuwarden, the Netherlands. The primary diagnosis of nonpsychotic MDD was confirmed by a psychiatrist or specialized clinical psychologist, according to DSM-IV criteria, and a score ≥14 on the Dutch 21-item Beck Depression Inventory Second Edition (BDI-II-NL, Beck et al, 1996 ;Van der Does, 2002 ). Only data from patients who were prescribed with ADs were included.…”