Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate

Trejo-Soto, Claudia; Hernández–Machado, A.

doi:10.3390/mi13030357

Cited by 10 publications

(7 citation statements)

References 69 publications

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“…As the respective error bars overlapped in the shear rate range of 10 0 -10 3 1/s, we concluded that the presence of RBCs after centrifugation did not exert any effect on the shear viscosity of follicular fluids. Generally, in whole blood, shear viscosity increases with increasing concentration of RBCs in the plasma (low-viscosity Newtonian fluids) [32]. However, this effect was negligible in this study, indicating that the concentration of RBCs in follicular fluids was visibly minute.…”

Section: Shear Viscosity Of Follicular Fluidscontrasting

confidence: 53%

Rheological characterization of human follicular fluid under shear and extensional stress conditions

Muto,

Kikuchi,

Yoshino

et al. 2023

Front. Phys.

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The rheology of human follicular fluid has been empirically evinced to be related to the reproductive health status of individuals, which supports its use as an indicator for improving the success rates of in vitro fertilization. However, there is a dearth of studies investigating the viscoelastic properties of human follicular fluid. Moreover, a comprehensive elucidation of the rheological properties of complex fluids necessitates the assessment of data regarding both shear and extensional viscosities. Nonetheless, to the best of our knowledge, the extant literature does not include reports on the behavior of follicular fluid under extensional conditions. Consequently, this study aimed to analyze the shear and extensional viscosities of human follicular fluid. Primarily, the impact of oocytes on the rheology of follicular fluid was evaluated by measuring the shear viscosity of this fluid using a high-resolution coaxial cylinder viscometer. The shear viscosity of follicular fluid exhibited marked differences depending on the presence or absence of oocytes. Subsequently, a measurement system that enables the handling of minute quantities of body fluid was developed to determine the extensional viscosity of follicular fluid, which contains albumin. A comparison of the acquired follicular fluid data with that of the protein solution containing albumin demonstrated that the follicular fluid alone displayed extensional behavior, whereas the protein solution did not. Therefore, it can be inferred that the protein solution is not its sole determinant, as other constituents of the fluid, such as peptides and cumulus cells, may determine its rheological properties. This observation was not attained through the conventional technique consisting in shear viscosity measurements.

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Section: Shear Viscosity Of Follicular Fluidscontrasting

confidence: 53%

Rheological characterization of human follicular fluid under shear and extensional stress conditions

Muto,

Kikuchi,

Yoshino

et al. 2023

Front. Phys.

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“…Viscous losses result in the absorption of ultrasonic energy directly affecting the attenuation, as it is clear from relation 3, is reported to increase as a storage lesion and was linked to a series of structural and biochemical alterations [36]. The rheological properties of blood, which have been demonstrated to follow a non-Newtonian behavior [37], where the viscosity increases with decreased shear rates [38], high spatial shear strain rates would be essential for a capillary flow rate for blood preserved more than three weeks. The modifications that occur, including the increased cellular buoyancy in blood drawn for donation as storage lesions [39] and increased aggregation [36], can also contribute to the attenuation.…”

Section: Resultsmentioning

confidence: 99%

Ultrasonic testing of the biomechanical properties of donation blood

Mohamed

Pomarède

Mangin

et al. 2023

Biomed. Phys. Eng. Express

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Background: Donated blood is routinely preserved for about six weeks. After that, a considerable amount of unused blood is discarded for safety. We carried out sequential measurements of the ultrasonic parameters (Velocity of propagation of ultrasound, its attenuation, and relative nonlinearity coefficient B/A) for red blood cell (RBCs) bags in their physiological preserving conditions in the blood bank to investigate the gradual deteriorations in the biomechanical properties of RBCs. Materials and Methods: We discuss our primary findings, which indicate the applicability of ultrasound techniques as a quantitative quick, non-invasive routine check for the validity of sealed blood bags. The technique can be applied during and beyond the regular preservation period, thus enabling deciding for each bag to either further preserve or withdraw. Results and Discussion: Considerable increases in the velocity of propagation (V = 966 m/s) and ultrasound attenuation ( = 0.81dB/Cm) were detected to take place during the preservation time. Likewise, the relative nonlinearity coefficient showed a generally rising trend during the preservation period ( (B/A) = 0.0129). At the same time, a distinctive feature characteristic of a specific blood group type is realized in all cases.Due to the complex stress-strain relations and their reflection on the hydrodynamics and flow rate of non-Newtonian fluids, the increased viscosity of long-preserved blood may justify the known post-transfusion flow complications.

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“…Hematocrit also participates in the hemodynamic interactions inside blood capillaries (Boal, 2001;Spann et al, 2016;Bouchnita et al, 2021). Known to fluctuate from one patient to another, hematocrit can reach 45% and can significantly modify the rheological properties of blood, including its viscosity and cellular interactions (Nader et al, 2019;Trejo-soto and Hernández-machado, 2022). In fact, the impact of hematocrit is particularly clear from a micro-rheological point of view: when analysing the in vivo distribution of RBCs, it was observed that the vascular network, and more specifically the subsequent and smallest generations, experience a heterogeneous distribution of hematocrit as a consequence of successive microvascular bifurcations and uneven velocity distributions (Chien et al, 1985;Fenton et al, 1985;Pries et al, 1989).…”

Section: Figurementioning

confidence: 99%

Design of artificial vascular devices: Hemodynamic evaluation of shear-induced thrombogenicity

Feaugas

Newman²,

Calzuola³

et al. 2023

Front. Mech. Eng.

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Blood-circulating devices such as oxygenators have offered life-saving opportunities for advanced cardiovascular and pulmonary failures. However, such systems are limited in the mimicking of the native vascular environment (architecture, mechanical forces, operating flow rates and scaffold compositions). Complications involving thrombosis considerably reduce their implementation time and require intensive anticoagulant treatment. Variations in the hemodynamic forces and fluid-mediated interactions between the different blood components determine the risk of thrombosis and are generally not taken sufficiently into consideration in the design of new blood-circulating devices. In this Review article, we examine the tools and investigations around hemodynamics employed in the development of artificial vascular devices, and especially with advanced microfluidics techniques. Firstly, the architecture of the human vascular system will be discussed, with regards to achieving physiological functions while maintaining antithrombotic conditions for the blood. The aim is to highlight that blood circulation in native vessels is a finely controlled balance between architecture, rheology and mechanical forces, altogether providing valuable biomimetics concepts. Later, we summarize the current numerical and experimental methodologies to assess the risk of thrombogenicity of flow patterns in blood circulating devices. We show that the leveraging of both local hemodynamic analysis and nature-inspired architectures can greatly contribute to the development of predictive models of device thrombogenicity. When integrated in the early phase of the design, such evaluation would pave the way for optimised blood circulating systems with effective thromboresistance performances, long-term implantation prospects and a reduced burden for patients.

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Normalization of Blood Viscosity According to the Hematocrit and the Shear Rate

Cited by 10 publications

References 69 publications

Rheological characterization of human follicular fluid under shear and extensional stress conditions

Rheological characterization of human follicular fluid under shear and extensional stress conditions

Ultrasonic testing of the biomechanical properties of donation blood

Design of artificial vascular devices: Hemodynamic evaluation of shear-induced thrombogenicity

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