Normal Values of Echocardiographic Parameters in Relation to Age in a Healthy Japanese Population The JAMP Study

Abstract

chocardiography is now recognized as an integral diagnostic tool that enables noninvasive quantification of cardiac chamber size, ventricular mass, and function in the clinical setting. Furthermore, technological advancement in Doppler echocardiography enables quantitative assessment of ventricular diastolic function as well as systolic function. Thus, echocardiography has become an important cardiac imaging technique in a number of clinical trials evaluating the efficacy of drug treatments or new therapeutic strategies.A guideline for quantifying cardiac chamber size and function using echocardiography, and references values for Circulation Journal Vol.72, November 2008 these echocardiographic measurements, were provided by the American Society of Echocardiography in conjunction with the European Association of Echocardiography. 1 Likewise, Doppler echocardiographic criteria for assessing left ventricular (LV) diastolic function were provided by the Canadian Consensus, 2 European 3 and American Medical Association guidelines, 4 and diastolic function parameters were reported to decline gradually with age. 5 However, most of these data are derived from American and European populations and because physical 6,7 and racial 8-10 differences can influence cardiac chamber size and function, it is important to evaluate the echocardiographic parameters in other populations. Reference values based on a large Asian population have not been previously reported, although some investigators have reported these values in a small population. 11 In addition, most studies that have investigated the relationship between age and cardiac chamber size and function have focused on a few parameters and have not assessed all of them in a large population.Accordingly, we designed and conducted a multicenter study, the Japanese Normal Values for Echocardiographic Measurements Project (JAMP) study, to determine the normal values for echocardiographic measurements and evaluate the relationship between these parameters and age in a large, healthy Japanese population. J 2008; 72: 1859 -1866 (Received February 27, 2008 revised manuscript received June 11, 2008; accepted June 26, 2008; released online September 29, 2008) Circ

Geographic variation in left ventricular mass and mass index: a systematic review

“…[13][14][15][16][17] The LVM from eight cohorts matched the upper ASE reference limit ( ± 10 g) 12,[18][19][20][21][22][23][24] (two studies included subjects from the cohorts used to create the reference range, 12,22 and one appears to be the study on which the twodimensional reference ranges were based 23 ), and LVM from seven cohorts was less than the upper ASE reference limit. 12,[25][26][27][28][29][30] Of those that were less than the upper ASE reference limit, three studies from Asia 25,26,30 had upper values on average 38 g less than the ASE reference limits for m-mode or two-dimensional measurements. A cohort of American Blacks included in the development of the ASE Systematic review of left ventricular mass KK Poppe et al reference ranges were 25 g less, 12 another study from the US was up to 41 g less, 29 and two cohorts from Brazil were 15 g less.…”

“…Indexation of mass by BSA did not remove the disparity between studies and the reference ranges (Figure 3a). Of the 24 cohorts that report both indexed and unindexed mass, nine still exceeded the upper ASE reference limit for LVMI ( ± 5 g m À2 ) [13][14][15]17,21,[30][31][32][33] and five had ranges up to 29 g m À2 below the upper ASE reference limit. 12,19,25,27,29 Women In women, the range of measured LVM was compatible with the ASE reference range in a greater number of studies than in men; however, LVM from eight cohorts (seven studies) still exceeded the upper ASE reference value by 11-92 g (mean 40 g) (Figure 2b).…”

“…As occurred in men, indexation of mass by BSA did not remove the disparity between studies and the reference ranges, and actually seemed to increase the heterogeneity (Figure 3b). Of the 12 cohorts with an upper value within 10 g of the upper ASE reference limit for LVM, three were reclassified as exceeding the upper ASE reference 26,28,30 and one reclassified as falling below the upper ASE reference 24 after indexation by BSA.…”

Tissue Doppler Echocardiography for Predicting Arterial Stiffness Assessed by Cardio-Ankle Vascular Index

“…As the mean age of the subjects in the present study is 69 ± 8 years old, the cutoff value of E' (5.6 cm/s) for detection of abnormal CAVI was considerably lower than the normal value for the healthy Japanese population. Therefore, we suppose that the decreased E' value proposed by Daimon et al (2008) may indeed predict increased arterial stiffness and the presence of coronary atherosclerosis. Second, the mean value of E/A (0.77 ± 0.18) was lower and the LVMI (116 ± 37 g/m 2 ) was higher than those in the previous studies (Mizuguchi et al 2007;Sakane et al 2008).…”

“…Our data showed that the cut-off value of E' for detection of abnormal CAVI values was 5.6 cm/s. Recently, normal values of echocardiographic parameters in a healthy Japanese population have been reported in various age strata (Daimon et al 2008). According to that report, normal values for E' are 7.3 ± 1.8 cm/s for healthy Japanese men in their sixties and 6.7 ± 2.1 cm/s for those in their seventies, respectively.…”