Normal Values of Corneal Optical Densitometry Using Pentacam Scheimpflug Camera

Abstract

Purpose: The purpose of the study was to illustrate the range of normal values of corneal densitometry using Pentacam Scheimpflug camera. Methodology:Prospective study was conducted at tertiary care Amanat eye hospital. 490 eyes of 490 participants of different age groups were added. All scans were performed in diagnostics room with uniform ambient light, performed by trained ophthalmic technologist. All participants were Pakistani of different ethnic groups. Only one eye of each participant was included to control biasness. T test, One-way ANOVA, pearson correlation coefficient and linear regression model tests were applied for analysis.Results: 490 eyes; 247 right eyes and 243 left eyes were analyzed. Mean age was 41.7±15.27 years (range 20-81 years) with 48.4% male and 51.6% females. based on corneal depth; highest backward scattering of light was observed in anterior (120 µm) layer (20.6±8.52 GSU) than central and posterior layers 13.6±5.17 GSU and 11.7±3.99 GSU respectively. The difference was statistically significant among layers with p< 0.001. Based on corneal surface, minimum backscattering was noted in central 0-6mm zone which increases from central to limbal zone; 0-2mm zone was 13.2±3.81 GSU, 2-6mm zone was 12.6±3.68 GSU, 6-10mm zone was 16.0±8.90 GSU and 10-12mm zone was 22.1±8.26 GSU. The difference was statistically significant with p<0.001. Significant correlation of corneal densitometry and age was observed r= 0.677, p<0.001. Conclusion:Objective assessment of corneal densitometry can be made with Pentacam Scheimpflug. Normative values of corneal density may be used in routine clinical practice and provided a reference for future research.

Corneal Densitometry Assessed With Scheimpflug Camera in Healthy Corneas and Correlation With Specular Microscopy Values and Age

“…In our study, corneal densitometry, in the examined central 0- to 2-mm zone, was found to be significantly positively correlated with age, both at each layer separately (anterior, central, and posterior) and in total. These results come in accordance with those of Asrar et al 18 who found significant correlation between age and corneal densitometry in every annular concentric zone and corneal layer. The increase in densitometry over aging might reflect the age-related changes that take place in all corneal layers, such as disruption of the epithelial cell barrier function, reduction of keratocyte density, breakdown of collagen fibers and appearance of collagen-free spaces, dysgenic or apoptotic cellular remnants in the aged stroma, such as lipofuscin granules (corneal farinata), and reduction of endothelial CD.…”

Corneal Densitometry in Chinese Adults with Healthy Corneas: Associations with Sex, Age, Ocular Metrics, and Optical Characteristics

“…Consequently, age-related alterations in the endothelial layer could contribute to the observed increase in CD values. Consistent with the study conducted by Asrar and Ni Dhubhghaill et al [2,17], our ndings indicated a strong association between peripheral corneal backscatter and age. This correlation may be attributed to the development of age-related limbal deformations, including the farinata, Arcus senilus/lipoides, crocodile shagreen, Vog''s white limbal girdle, and Hassal-Henle bodies.…”

Effects of descemet stripping automated endothelial keratoplasty on corneal densitometry of cases with long-standing pseudophakic bullous keratopathy

“… 30 Moreover, different studies have shown a range of 4–19 with a mean of 12 for densitometries in the normal corneas, and the anterior layer has always had the most density with a mean of about 19. 21 31 32 It could be mentioned that peripheral corneal densitometry values remarkably increase with aging. It seems that corneal densitometry can be an indicator for endothelial cell properties.…”