Normal values for noninvasive estimation of left ventricular contractile state and afterload in children

Franklin, Rodney C. G.; Wyse, Richard K.H.; Graham, T.P.; Gooch, V; Deanfield, John

doi:10.1016/0002-9149(90)90819-m

Cited by 43 publications

(14 citation statements)

References 24 publications

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“…It is well known that there is an inverse and linear correlation between mVcfc and ESS, not only in adults but in children and healthy term infants [10,16,18]. Studies have shown that a similar relation exists in low birth weight infants at a few weeks of age [17,23].…”

Section: Discussionmentioning

confidence: 99%

Postnatal Left Ventricular Contractility in Very Low Birth Weight Infants

et al. 1997

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The objective of the study was to evaluate postnatal changes in left ventricular (LV) contractility in very low birth weight (VLBW) infants. An echocardiographic study comparing 18 VLBW infants without significant complications and 16 normal term infants was carried out at the Neonatal Intensive Care Unit in Akita University Medical Hospital, Japan. The echocardiographic examinations were performed within 6 hours of birth and on day 5. We obtained the relations between rate-corrected mean velocity of circumferential fiber shortening (mVcfc) and end-systolic wall stress (ESS), which were calculated from two-dimensional LV short-axis views to compensate for the distorted LV shape, and we compared these relations statistically. In both VLBW and term infants there were inverse linear correlations between mVcfc and ESS for each study period (p < 0.05). The regression line of VLBW infants had a lower y-intercept and a steeper slope than that of term infants at 6 hours of age but almost corresponded on day 5. It is concluded that the left ventricle of VLBW infants adapts to postnatal hemodynamic alterations with low contractility but operates with a contractile state similar to that of term infants on day 5.

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Section: Discussionmentioning

confidence: 99%

Postnatal Left Ventricular Contractility in Very Low Birth Weight Infants

et al. 1997

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“…Cardiac evaluation consisted of the left ventricular shortening fraction (SF) calculated by the following formula: SF ‫ס‬ [(left ventricular end diastolic diameter − end systolic diameter)/end diastolic diameter] × 100. The normal range is 28%-44% [12].…”

Section: Methodsmentioning

confidence: 98%

Late effects of chemotherapy compared to bone marrow transplantation in the treatment of pediatric acute myeloid leukemia and myelodysplasia

Leahey

Teunissen

Friedman

et al. 1999

Med. Pediatr. Oncol.

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“…(2) Analysis of LV systolic function, afterload and contractile state: The parameters obtained from the M-mode parasternal short axis cut of the left ventricle were used to calculate: (a) % fractional shortening (FS); (b) mean velocity of circumferential shortening of the fibers, corrected by HR (mVCFc) [17, 18]; (c) end-systolic meridional stress (ESSm) [19, 20], index of afterload (e.g. the resistance against which blood is expelled at the end of the systole), with end-systolic pressure estimated from the peak systolic and diastolic BP using a regression equation [21](this method was validated by using invasive measurements), and (d) stress-velocity index (SVI), a parameter of LV contractile state, using the method of Colan [22].…”

Section: Methodsmentioning

confidence: 99%

Cardiac Performance in Turner’s Syndrome Patients on Growth Hormone Therapy

et al. 2001

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Objectives: To investigate possible cardiac morphofunctional alterations observed in 26 Turner’s syndrome (TS) patients on prolonged high-dose growth hormone (GH) therapy. Study Design: We examined 26 TS subjects treated with rhGH (1 U/kg/week) for a mean period of 4.9 years (range 1–7.8) and 37 age-, weight- and height-matched healthy girls. Left ventricular volume, mass, systolic function, cardiac index, systemic vascular resistance and diastolic function were evaluated by two-dimensional and Doppler echocardiography. Results: Heart rate and systolic blood pressure (BP) were higher in TS patients than in controls, while diastolic BP was lower. Left ventricular volumes, ejection fraction, mass index, M/V ratio and cardiac index did not differ significantly; systemic vascular resistance was slightly decreased. Left ventricular fractional shortening and mean velocity of circumferential shortening were slightly increased while end-systolic meridional stress was decreased in TS. Contractile state was normal in TS. Diastolic function assessment showed a shortening of isovolumetric relaxation and diastolic filling times with an increased atrial contribution and a normal pulmonary venous flow. Conclusion: Cardiac morphology in TS patients on GH therapy is similar to controls. The observed changes in left ventricular systolic and diastolic function should be interpreted as an adaptation to the higher heart rate and reduced peripheral vascular resistance induced by GH therapy.

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Normal values for noninvasive estimation of left ventricular contractile state and afterload in children

Cited by 43 publications

References 24 publications

Postnatal Left Ventricular Contractility in Very Low Birth Weight Infants

Postnatal Left Ventricular Contractility in Very Low Birth Weight Infants

Late effects of chemotherapy compared to bone marrow transplantation in the treatment of pediatric acute myeloid leukemia and myelodysplasia

Cardiac Performance in Turner’s Syndrome Patients on Growth Hormone Therapy

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