Normal Values for Microperimetry with the MAIA Microperimeter: Sensitivity and Fixation Analysis in Healthy Adults and Children

Molina‐Martín, Ainhoa; Piñero, David P.; Pérez-Cambrodí, Rafael J.

doi:10.5301/ejo.5000930

Cited by 38 publications

(29 citation statements)

References 35 publications

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“…38,39 The Mean Sensitivity index declined with age (regression coefficient À0.04 dB/year, R 2 ¼ 0.30, P , 0.001). This outcome is consistent with that of À0.01 to À0.02 dB/year for microperimetry [40][41][42] and of À0.04 to À0.08 dB/year for SAP within 108. 15,17 In addition, the ranges of sensitivity values are consistent with those reported for ocular healthy individuals 43,44 and for those with AMD.…”

Section: Discussionsupporting

confidence: 89%

Microperimetry in Age-Related Macular Degeneration: An Evidence-Base for Pattern Deviation Probability Analysis in Microperimetry

Cassels

Wild

Margrain

et al. 2019

Trans. Vis. Sci. Tech.

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Purpose: The ''traffic light'' color designation of differential light sensitivity used in a number of microperimeters does not encompass the conventional Total and Pattern Deviation probability analyses adopted by standard automated perimetry. We determined whether the color designation is indicative of abnormality as represented by the ''gold standard'' Pattern Deviation probability analysis. Methods: Total and Pattern Deviation probability levels, using two different methods, were derived at each of 40 stimulus locations, within 78 eccentricity, from 66 ocular healthy individuals (66 eyes) who had undergone microperimetry with the Macular Integrity Assessment microperimeter. The probability levels were applied to the corresponding fields from each of 45 individuals (45 eyes) with age-related macular degeneration (AMD) and evaluated in relation to the color designation. Results: Sensitivities designated in orange encompassed the entire range of Pattern Deviation probability levels (from normal to P 1%). Those designated in green were mostly normal; those in red/black generally corresponded to the 1% probability level. Conclusions: The green and the red/black designations are generally indicative of normal and abnormal probability values, respectively. The orange designation encompassed all probability outcomes and should not be relied upon for visual field interpretation. The evidence base indicates replacement of the color designation of sensitivity in AMD by Total Deviation and Pattern Deviation analyses. Translational Relevance: The use of Total and Pattern Deviation probability analyses is not universal in all microperimeters, and the derivation of these values indicates that color coding will lead to errors in evaluating visual field loss.

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Section: Discussionsupporting

confidence: 89%

Microperimetry in Age-Related Macular Degeneration: An Evidence-Base for Pattern Deviation Probability Analysis in Microperimetry

Cassels

Wild

Margrain

et al. 2019

Trans. Vis. Sci. Tech.

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“…Microperimetry was performed (experiment 2) using the MAIA, a microperimeter with inbuilt confocal scanning laser ophthalmoscope and eye tracker. 19 , 20 MAIA uses a 25-Hz eye tracker to monitor fixation, performs retinal imaging using a scanning laser ophthalmoscope, and generates targets by projecting light from a white light-emitting diode (LED) directly onto the retina. MAIA measures differential light sensitivity based on the ability of observers to reliably report seeing a brief spot of light at each sample location using a 4-2 threshold strategy in which luminance is adjusted by increments of 4 dB for increases and 2 dB for decreases.…”

Section: Methodsmentioning

confidence: 99%

Multi-line Adaptive Perimetry (MAP): A New Procedure for Quantifying Visual Field Integrity for Rapid Assessment of Macular Diseases

Thurman

Maniglia

Davey

et al. 2018

Trans. Vis. Sci. Tech.

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PurposeIn order to monitor visual defects associated with macular degeneration (MD), we present a new psychophysical assessment called multiline adaptive perimetry (MAP) that measures visual field integrity by simultaneously estimating regions associated with perceptual distortions (metamorphopsia) and visual sensitivity loss (scotoma).MethodsWe first ran simulations of MAP with a computerized model of a human observer to determine optimal test design characteristics. In experiment 1, predictions of the model were assessed by simulating metamorphopsia with an eye-tracking device with 20 healthy vision participants. In experiment 2, eight patients (16 eyes) with macular disease completed two MAP assessments separated by about 12 weeks, while a subset (10 eyes) also completed repeated Macular Integrity Assessment (MAIA) microperimetry and Amsler grid exams.ResultsResults revealed strong repeatability of MAP and high accuracy, sensitivity, and specificity (0.89, 0.81, and 0.90, respectively) in classifying patient eyes with severe visual impairment. We also found a significant relationship in terms of the spatial patterns of performance across visual field loci derived from MAP and MAIA microperimetry. However, there was a lack of correspondence between MAP and subjective Amsler grid reports in isolating perceptually distorted regions.ConclusionsThese results highlight the validity and efficacy of MAP in producing quantitative maps of visual field disturbances, including simultaneous mapping of metamorphopsia and sensitivity impairment.Translational RelevanceFuture work will be needed to assess applicability of this examination for potential early detection of MD symptoms and/or portable assessment on a home device or computer.

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“…We were able to recruit 21 children with established pathology where visual field changes might be expected and all children completed the test satisfactorily. Median age was 12 (range, [4][5][6][7][8][9][10][11][12][13][14][15][16]. Thirteen children had congenital glaucoma, seven had secondary glaucoma, and one had neurological damage to a temporal lobe.…”

Section: Resultsmentioning

confidence: 99%

“…9 This was a key step as although many visual fields are performed in children every year, most tests are designed for adults and few instruments have a normative database for children. 10,11 The current version of our test incorporates our recent developments and normative values into a system of gamebased perimetry designed specifically for children and known as Caspar's Castle.…”

mentioning

confidence: 99%

Diagnostic Performance and Repeatability of a Novel Game-Based Visual Field Test for Children

Aslam

Ali

Wang

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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Normal Values for Microperimetry with the MAIA Microperimeter: Sensitivity and Fixation Analysis in Healthy Adults and Children

Abstract: Retinal sensitivity in healthy eyes tends to decrease with age as well as the stability of the pattern of fixation. A normative database in terms of retinal sensitivity threshold and fixation performance can be established in this type of eyes.

Cited by 38 publications

References 35 publications

Microperimetry in Age-Related Macular Degeneration: An Evidence-Base for Pattern Deviation Probability Analysis in Microperimetry

Microperimetry in Age-Related Macular Degeneration: An Evidence-Base for Pattern Deviation Probability Analysis in Microperimetry

Multi-line Adaptive Perimetry (MAP): A New Procedure for Quantifying Visual Field Integrity for Rapid Assessment of Macular Diseases

Diagnostic Performance and Repeatability of a Novel Game-Based Visual Field Test for Children

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