Normal uptake of 18F-FDG in the testis: an assessment by PET/CT

Kitajima, Kazuhiro; Nakamoto, Yuji; Senda, Michio; Onishi, Yoshiaki; Okizuka, Hiromi; Sugimura, Kazuro

doi:10.1007/s12149-007-0041-z

Cited by 50 publications

(53 citation statements)

References 21 publications

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“…In the present study, 18 F-FDG PET/CT was performed in 66 normal healthy men, and a significant negative correlation was found between T/M ratio and age, which is consistent with the results of a previous study [6]. However, no significant correlation was found between mean testicular SUV and age, which does not concur with the findings of Kazuhiro et al, in which a weak, albeit significant negative correlation was found between the two [5]. There may have been other factors affecting testicular SUV such as testicular volume or sexual activity.…”

Section: Discussionsupporting

confidence: 89%

“…However, ages in this study were more evenly distributed than in previous studies. Kazuhiro et al evaluated 203 cancer patients, however only 6 subjects were aged 30-39 years and no subjects were 20-29 years old [5]. Twenty-one percent of subjects were under 40 years old in our study, whereas only 2.95% of subjects were under 40 years old in Kazuhiro's study.…”

Section: Discussioncontrasting

confidence: 67%

“…Our findings indicate that 18 F-FDG PET can be used to evaluate testicular function. As far as we are aware three previous studies have previously examined normal 18 F-FDG uptake in human testes [5,6,8]. These studies demonstrated a significant correlation between normal testicular 18 F-FDG uptake and age.…”

Section: Discussionmentioning

confidence: 91%

“…SUV of testis may be affected by testicular volume. Age-associated atrophy and partial volume effect could affect the correlation between SUV and age [5].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, a small number of studies have examined 18 F-FDG uptake in normal testes [5,6] and concluded that 18 F-FDG uptake declines slightly with age. However, in these studies the number of healthy subjects examined was small, and almost all were cancer patients, and it is known that cancer can alter glucose metabolism in the testis.…”

Section: Introductionmentioning

confidence: 99%

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18F-FDG Uptake of Human Testis on PET/CT: Correlation with Age, Sex Hormones, and Vasectomy

Moon

Lee

et al. 2011

Nucl Med Mol Imaging

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Purpose The purpose of this study was to evaluate glucose metabolism of normal human testis on 18 F-FDG PET/CT and to assess possible correlations among age, the serum levels of sex hormones, and vasectomy. Methods 18 F-FDG PET/CT was performed in 66 normal healthy men (50.8±13.6 years, range 22-81), and mean standard uptake values (SUV) of 18 F-FDG in testis and adductor muscle were measured. Testis-muscle SUV ratios (T/M ratios) were calculated. Serum levels of total testosterone, free testosterone, estradiol, and of sex-hormone binding globulin (SHBG) were measured. We searched for correlations between T/M ratios and age and the serum concentrations of sex hormones. 18 F-FDG PET/CT was also performed in 32 vasectomized men (55.7±7.8 years, range 38-71) and 52 nonvasectomized men (55.4±11.6 years, range 37-72). Mean SUVs of testis and adductor muscle were measured, and T/M ratios were calculated. Results A significant age-related decline was found in T/M ratio (r=−0.509, p<0.0001). Serum levels of total testosterone and free testosterone were also found to be positively correlated with T/M ratio (r=0.427, p=0.0003; r=0.435, p=0.0003, respectively). The mean SUV and T/M ratio of vasectomized men were significantly lower than those of nonvasectomized men (p<0.0378 and p=0.0001, respectively).Conclusions Glucose metabolism in the testis in an adult population was found to be correlated with age, serum sex hormone level, and vasectomy history. These results indicate that testicular 18 F-FDG uptake may have attributed to testicular function and testicular histology. Our findings may have important implications for the interpretation of testicular 18 F-FDG uptake in the normal adult population.

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 67%

Section: Discussionmentioning

confidence: 91%

“…SUV of testis may be affected by testicular volume. Age-associated atrophy and partial volume effect could affect the correlation between SUV and age [5].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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18F-FDG Uptake of Human Testis on PET/CT: Correlation with Age, Sex Hormones, and Vasectomy

Moon

Lee

et al. 2011

Nucl Med Mol Imaging

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Testicular FDG‐PET/CT uptake threshold in aggressive lymphomas

et al. 2021

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Assessment of testicular uptake in flourine‐18 fluorodeoxyglucose positron emission tomography/computed tomography

Han

Lee

Sohn

et al. 2012

Int J Imaging Syst Tech

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The testis shows physiologic uptake in flourine-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET). The purpose of this study was to examine the degree of FDG uptake of normal testis on PET/computed tomography (CT), especially in relationship to various clinical parameters. We obtained the maximum standardized uptake value (SUVmax) and the mean standardized uptake value (SUVmean) of each testis from PET/CT of 166 healthy men. We also calculated the testis-to-muscle (T/M) ratio, defined as the SUVmean of the testis divided by the SUVmean of the right thigh muscle. Subjects completed a questionnaire on their medical history and sexual habits, including frequency of sexual intercourse, latest date of sexual intercourse, and vasectomy history. We then evaluated the association between imaging parameters and sexual habits. The mean age of subjects was 48 AE 10 years (range, 21-74), and the mean volume of each testis was 17.1 AE 4.5 cm 3 (range, 7.4-32.4). The mean SUVmax was 3.6 AE 0.5 (range, 2.2-5.5), the mean SUVmean was 2.5 AE 0.4 (range, 1.6-3.8), and the mean T/M ratio was 4.2 AE 0.8 (range, 2.3-7.3). Of the 166 subjects, 51 reported having sexual intercourse zero times per month and 109 had sexual intercourse at least per month. The interval between the latest date of sexual intercourse and PET/CT was less than 3 days in 48 subjects; between 3 days and 1 month in 58; and greater than 1 month in 60. Twenty subjects were currently vasectomized. The T/M ratio was significantly correlated with age (P 5 0.040) but not with sexual habits. On the PET/CT, normal testicular FDG uptake decreased as age increased.

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Normal uptake of 18F-FDG in the testis: an assessment by PET/CT

Abstract: Some uptake of FDG is observed in the normal testis and declines slightly with age. Physiological FDG uptake in the testis should not be confused with pathological accumulation.

Cited by 50 publications

References 21 publications

18F-FDG Uptake of Human Testis on PET/CT: Correlation with Age, Sex Hormones, and Vasectomy

18F-FDG Uptake of Human Testis on PET/CT: Correlation with Age, Sex Hormones, and Vasectomy

Testicular FDG‐PET/CT uptake threshold in aggressive lymphomas

Assessment of testicular uptake in flourine‐18 fluorodeoxyglucose positron emission tomography/computed tomography

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