Normal to enhanced intrinsic mitochondrial respiration in skeletal muscle of middle- to older-aged women and men with uncomplicated type 1 diabetes

Monaco, Cynthia M. F.; Tarnopolsky, Mark A.; Dial, Athan G.; Nederveen, Joshua P.; Rebalka, Irena A.; Nguyen, Mike; Turner, Lauren V.; Perry, Christopher G. R.; Ljubicic, Vladimir; Hawke, Thomas J.

doi:10.1007/s00125-021-05540-1

Cited by 8 publications

(9 citation statements)

References 45 publications

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“…Although these differences might not be crucial in healthy people, the longer duration of the disease combined with reduced physical activity levels could have accelerated the muscle degeneration and thus manifested a different phenotype (Kalyani et al 2015;Oikawa et al 2019). This observation is supported by the most recent study from Monaco et al that identified impaired OXPHOS oxidative capacity and reduced mitochondrial area density in an older cohort of people with type 1 diabetes (Monaco et al 2021). Furthermore, a recent study from Heyman and colleagues identified a negative relationship between the duration of diabetes, glycaemic control and mitochondrial functioning (Heyman et al 2020).…”

Section: Discussionmentioning

confidence: 80%

“…that identified impaired OXPHOS oxidative capacity and reduced mitochondrial area density in an older cohort of people with type 1 diabetes (Monaco et al . 2021 ). Furthermore, a recent study from Heyman and colleagues identified a negative relationship between the duration of diabetes, glycaemic control and mitochondrial functioning (Heyman et al .…”

Section: Discussionmentioning

confidence: 99%

“…Despite growing information related to loss of muscle health in people living with type 1 diabetes, the specific triggering events remain largely unknown. Recently, alterations in mitochondrial ultrastructure, bioenergetics and mitochondrial area density were identified as the most evident impairment in the muscle of humans with type 1 diabetes (Monaco et al 2018(Monaco et al , 2021.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, alterations in mitochondrial ultrastructure, bioenergetics and mitochondrial area density were identified as the most evident impairment in the muscle of humans with type 1 diabetes (Monaco et al . 2018 , 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Altered muscle mitochondrial, inflammatory and trophic markers, and reduced exercise training adaptations in type 1 diabetes

Minnock

Annibalini

Valli

et al. 2022

The Journal of Physiology

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Growing evidence of impaired skeletal muscle health in people with type 1 diabetes points toward the presence of a mild myopathy in this population. However, this myopathic condition is not yet well characterised and often overlooked, even though it might affect the whole‐body glucose homeostasis and the development of comorbidities. This study aimed to compare skeletal muscle adaptations and changes in glycaemic control after 12 weeks of combined resistance and aerobic (COMB) training between people with type 1 diabetes and healthy controls, and to determine whether the impaired muscle health in type 1 diabetes can affect the exercise‐induced adaptations. The COMB training intervention increased aerobic capacity and muscle strength in both healthy and type 1 diabetes sedentary participants, although these improvements were higher in the control group. Better glucose control, reduced glycaemic fluctuations and fewer hypoglycaemic events were recorded at post‐ compared to pre‐intervention in type 1 diabetes. Analysis of muscle biopsies showed an alteration of muscle markers of mitochondrial functions, inflammation, ageing and growth/atrophy compared to the control group. These muscular molecular differences were only partially modified by the COMB training and might explain the reduced exercise adaptation observed in type 1 diabetes. In brief, type 1 diabetes impairs many aspects of skeletal muscle health and might affect the exercise‐induced adaptations. Defining the magnitude of diabetic myopathy and the effect of exercise, including longer duration of the intervention, will drive the development of strategies to maximise muscle health in the type 1 diabetes population. Key points Type 1 diabetes negatively affects skeletal muscle health; however, the effect of structured exercise training on markers of mitochondrial function, inflammation and regeneration is not known. Even though participants with type 1 diabetes and healthy control were comparable for cardiorespiratory fitness (trueV̇normalO2max${\dot{V}_{{{\rm{O}}_{\rm{2}}}{\rm{max}}}}$) and muscle strength at baseline, molecular markers related to muscle health were decreased in type 1 diabetes. After training, both groups increased trueV̇normalO2max${\dot{V}_{{{\rm{O}}_{\rm{2}}}{\rm{max}}}}$ and muscle strength; however, a larger improvement was achieved by the control group. The training intervention decreased glucose fluctuations and occurrence of hypoglycaemic events in type 1 diabetes, while signs of mild myopathy found in the muscle of participants with type 1 diabetes only partially improved after training Improving muscle health by specific exercise protocols is of considerable clinical interest in therapeutic strategies for improving type 1 diabetes management and preventing or delaying long‐term complications.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Altered muscle mitochondrial, inflammatory and trophic markers, and reduced exercise training adaptations in type 1 diabetes

Minnock

Annibalini

Valli

et al. 2022

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…Several recent human studies have demonstrated that the skeletal muscles of those with T1D exhibit numerous deficits, relative to matched non-T1D subjects, leading to the proposal that muscles of those with T1D exhibit accelerated ageing. These changes include decreases in strength , changes in myofibre morphology and size , impaired mitochondrial function (Monaco et al 2018(Monaco et al , 2021, ultrastructural abnormalities in mitochondria (Monaco et al 2018), increased mitochondrial ROS emission (Monaco et al 2018), and alterations to skeletal muscle repair following exercise . Notably, many of these alterations in muscle health were sexually dimorphic, present across a variety of ages, and evident despite similarities in self-reported physical activity levels with non-T1D matched subjects.…”

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confidence: 99%

Do those with type 1 diabetes need more exercise to maintain skeletal muscle health?

Hawke

2022

The Journal of Physiology

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Exercise in adults with type 1 diabetes mellitus

Riddell

Peters

2022

Nat Rev Endocrinol

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Normal to enhanced intrinsic mitochondrial respiration in skeletal muscle of middle- to older-aged women and men with uncomplicated type 1 diabetes

Cited by 8 publications

References 45 publications

Altered muscle mitochondrial, inflammatory and trophic markers, and reduced exercise training adaptations in type 1 diabetes

Altered muscle mitochondrial, inflammatory and trophic markers, and reduced exercise training adaptations in type 1 diabetes

Do those with type 1 diabetes need more exercise to maintain skeletal muscle health?

Exercise in adults with type 1 diabetes mellitus

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