Normal standards for fetal neurobehavioral developments – longitudinal quantification by four-dimensional sonography

Kurjak, Asım; Andonotopo, Wiku; Hafner, Tomislav; Kadić, Aida Salihagić; Stanojević, Milan; Azumendi, Guillermo; Ahmed, Badreldeen; Carrera, J. M.; Troyano, J. M.

doi:10.1515/jpm.2006.007

Cited by 127 publications

(193 citation statements)

References 21 publications

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“…In another study by this group, 100 women with normal singleton pregnancies were recruited for longitudinal 4D sonographic examinations to evaluate 11 fetal movement and expression parameters from the 15th to 40th weeks. 33 All types of facial expression were noted as displaying a peak frequency at the end of the second trimester, except for isolated eye blinking, the frequency of which increased at the beginning of the 24th week (Figs 9A to F). A tendency toward decreased frequency of facial expressions and movement patterns with increasing gestational age from second to third trimesters has also been noted.…”

Section: Late Second and Third Trimestersmentioning

confidence: 91%

“…In another study by this group, 100 women with normal singleton pregnancies were recruited for longitudinal 4D sonographic examination to evaluate fetal neurodevelopmental parameters from the 7th to 14th weeks. 33 The measurements of seven parameters (general movements, stretching, isolated arm and leg movements, head retroflexion, head rotation and head anteflexion) were correlated with the gestational age and these parameters showed an increasing frequency of fetal movement during the first trimester. However, the frequency of a startle pattern did not correlate with gestation in the first trimester.…”

Section: Jaypee Toshiyuki Hata Et Almentioning

confidence: 98%

“…[33][34][35]37,[39][40][41] All studies focused on the assessment of fetal facial expressions and movements, and fetal hand to face movements (Figs 6A to 8), because the viewing area was limited to that of the transabdominal probe. Kurjak et al 37 were the first to use 4D sonography to study 10 healthy fetuses for 15 minutes at 30 to 33 weeks.…”

Section: Late Second and Third Trimestersmentioning

confidence: 99%

“…The application of 4D sonography to the examination of fetal facial movements reveals the existence of a full range of facial expressions similar to emotional expression in adults. 18,19,33 Moreover, different facial expressions and movements depicted by 4D sonography might represent fetal awareness. 40 'The question raised here is whether or not facial expressions represent a reliable behavior or emotional state or constitute reflexive behavior on the part of the fetus'.…”

Section: Late Second and Third Trimestersmentioning

confidence: 99%

“…40 'The question raised here is whether or not facial expressions represent a reliable behavior or emotional state or constitute reflexive behavior on the part of the fetus'. 33 The answer to this question is currently unknown.…”

Section: Late Second and Third Trimestersmentioning

confidence: 99%

See 4 more Smart Citations

4D Sonography in Assessment of Fetal Neurobehavior

Hata¹,

Sato²,

Kanenishi³

et al. 2012

Donald School Journal of Ultrasound in Obstetrics and Gynecology

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ABSTRACT'Observation of fetal behavior reflects the functioning of the central nervous system, and behavioral assessment of the fetus enables the function of the brain to be examined'.1 The introduction of four-dimensional (4D) sonography techniques would facilitate fetal behavioral assessment in three dimensions in real time during pregnancy. We describe the latest 4D sonographic studies on fetal neurobehavior in all three trimesters of pregnancy. 4D sonography also facilitated the evaluation of interhuman contact and intrapair stimulation in twin pregnancies in utero. This novel technique may assist in the evaluation of fetal neurobehavior and intertwin contact and intrapair stimulation and offer potential advantages relative to conventional two-dimensional sonography. 4D sonography may become an important modality in future research on fetal neurobehavioral development and the prenatal identification of severely brain-damaged infants.

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Section: Late Second and Third Trimestersmentioning

confidence: 91%

Section: Jaypee Toshiyuki Hata Et Almentioning

confidence: 98%

Section: Late Second and Third Trimestersmentioning

confidence: 99%

Section: Late Second and Third Trimestersmentioning

confidence: 99%

Section: Late Second and Third Trimestersmentioning

confidence: 99%

See 3 more Smart Citations

4D Sonography in Assessment of Fetal Neurobehavior

Hata¹,

Sato²,

Kanenishi³

et al. 2012

Donald School Journal of Ultrasound in Obstetrics and Gynecology

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Prenatal behavior of the C57BL/6J mouse: A promising model for human fetal movement during early to mid‐gestation

Kleven

Ronca

2008

Developmental Psychobiology

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The study of fetal neurobehavioral development in genetically altered mice promises a significant advance in our understanding of the prenatal origins of developmental disabilities in humans. Despite their importance, little is known about fetal neurobehavioral development in mice. In this study, we observed prenatal behavioral patterns of the C57BL/6J mouse, a common background strain for genetically-altered mice, and report their similarity to those observed in the early-to-mid gestation human fetus. Fetal offspring from pregnant C57BL/6J dams were observed on the day before birth (E18 of a 19-day gestation). Scoring and analysis of fetal movement included Prechtl’s Method for Qualitative Assessment, Interlimb Movement Synchrony, a measure of the temporal relationship between movements of limb pairs, and Behavioral State, quantified through detailed analysis of high and low amplitude limb movements. With the exception of fetal breathing movements, all categories and patterns of behavior typically reported in the early-to-mid gestation human fetus were observed in the C57BL/6J mouse fetus. Our results suggest that behavioral analysis of fetal C57BL/6J mice may yield important new insights into early to mid-gestation human behavioral development.

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Identification of prenatal behavioral patterns of the gross motor movements within the early stages of fetal development

Merendonk

Brouwers

Catte

et al. 2016

Infant and Child Development

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Little is known about the manner in which motor behavior of the gross motor movements develops in early fetal period. Therefore, the goal of this study was to identify and classify the fetal distinct behavior patterns of the gross motor movements qualitatively in gestational weeks 10 through 17 (N = 69 fetuses). Using our unique Systematic Observation and Analysis Procedure based on conventional 2D ultrasound, we were able to identify the distinct behavior patterns with respect to the fetus' orientation (e.g., postural position and additional support by uterine wall) in real time and therefore distinguish 12 categories of behavioral patterns. The kappa coefficient for this procedure was 0.82, indicating high interobserver reliability. Interestingly, six of these 12 categories were not observed in gestational week 10–11, whereas all 12 movement categories were present in gestational week 16–17. Importantly, the occurrence of early development of gross motor control in utero emerges in the presence of dynamic and interactive environmental factors, providing new insights into the fundamental aspects of developmental motor behavior in the growing infant. Highlights We developed a system for real‐time monitoring of behavioral patterns of the gross motor movements with respect to the fetus' intrauterine orientation using a two‐step, non‐invasive observation protocol. Our monitoring system allowed us to detect twelve separate categories of distinct behavioral patterns of the gross motor movements in gestational week 10–17. Gross motor control develops in the early fetal period and is affected by the presence of dynamic and interactive environmental factors.

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Normal standards for fetal neurobehavioral developments – longitudinal quantification by four-dimensional sonography

Cited by 127 publications

References 21 publications

4D Sonography in Assessment of Fetal Neurobehavior

4D Sonography in Assessment of Fetal Neurobehavior

Prenatal behavior of the C57BL/6J mouse: A promising model for human fetal movement during early to mid‐gestation

Identification of prenatal behavioral patterns of the gross motor movements within the early stages of fetal development

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