Normal Skeletal Muscle Function in Patients With Copd When Exercise Is Not Centrally Limited

Richardson, Russell S.; Leek, Bryan T.; Haseler, Luke J.; Gavin, Timothy P.; Sheldon, J.; Entin, Pauline L.; Olfert, I. Mark; Ries, Andrew L.; Wagner, Peter D.

doi:10.1097/00005768-199905001-01351

Medicine & Science in Sports & Exercise

1999

DOI: 10.1097/00005768-199905001-01351

|View full text |Cite

Normal Skeletal Muscle Function in Patients With Copd When Exercise Is Not Centrally Limited

Russell S. Richardson

Bryan T. Leek

Luke J. Haseler

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2004

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The purpose of this study was to test the following hypotheses: (1 ) during cycle exercise the skeletal muscle of patients with COPD will appear dysfunctional in comparison with that of control subjects in terms of maximal work rate, muscle blood flow, and V o 2 , whereas (2 ) during single leg knee-extensor exercise the skeletal muscle of patients with COPD will have a more similar physiologic response to that of the control subjects. This work has been previously published in abstract form (14).…”

mentioning

confidence: 99%

Reduced Mechanical Efficiency in Chronic Obstructive Pulmonary Disease but Normal Peak V̇o₂with Small Muscle Mass Exercise

Richardson

Leek

Gavin

et al. 2004

Am J Respir Crit Care Med

154

168

View full text Add to dashboard Cite

We studied six patients with chronic obstructive pulmonary disease (COPD) (FEV1 = 1.1 +/- 0.2 L, 32% of predicted) and six age- and activity level-matched control subjects while performing both maximal bicycle exercise and single leg knee-extensor exercise. Arterial and femoral venous blood sampling, thermodilution blood flow measurements, and needle biopsies allowed the assessment of muscle oxygen supply, utilization, and structure. Maximal work rates and single leg VO2max (control subjects = 0.63 +/- 0.1; patients with COPD = 0.37 +/- 0.1 L/minute) were significantly greater in the control group during bicycle exercise. During knee-extensor exercise this difference in VO2max disappeared, whereas maximal work capacity was reduced (flywheel resistance: control subjects = 923 +/- 198; patients with COPD = 612 +/- 81 g) revealing a significantly reduced mechanical efficiency (work per unit oxygen consumed) with COPD. The patients had an elevated number of less efficient type II muscle fibers, whereas muscle fiber cross-sectional areas, capillarity, and mitochondrial volume density were not different between the groups. Therefore, although metabolic capacity per se is unchanged, fiber type differences associated with COPD may account for the reduced muscular mechanical efficiency that becomes clearly apparent during knee-extensor exercise, when muscle function is no longer overshadowed by the decrement in lung function.

show abstract

mentioning

confidence: 99%

Reduced Mechanical Efficiency in Chronic Obstructive Pulmonary Disease but Normal Peak V̇o₂with Small Muscle Mass Exercise

Richardson

Leek

Gavin

et al. 2004

Am J Respir Crit Care Med

154

168

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Normal Skeletal Muscle Function in Patients With Copd When Exercise Is Not Centrally Limited

Cited by 1 publication

References 0 publications

Reduced Mechanical Efficiency in Chronic Obstructive Pulmonary Disease but Normal Peak V̇o₂with Small Muscle Mass Exercise

Reduced Mechanical Efficiency in Chronic Obstructive Pulmonary Disease but Normal Peak V̇o₂with Small Muscle Mass Exercise

Contact Info

Product

Resources

About

Normal Skeletal Muscle Function in Patients With Copd When Exercise Is Not Centrally Limited

Cited by 1 publication

References 0 publications

Reduced Mechanical Efficiency in Chronic Obstructive Pulmonary Disease but Normal Peak V̇o2with Small Muscle Mass Exercise

Reduced Mechanical Efficiency in Chronic Obstructive Pulmonary Disease but Normal Peak V̇o2with Small Muscle Mass Exercise

Contact Info

Product

Resources

About

Reduced Mechanical Efficiency in Chronic Obstructive Pulmonary Disease but Normal Peak V̇o₂with Small Muscle Mass Exercise

Reduced Mechanical Efficiency in Chronic Obstructive Pulmonary Disease but Normal Peak V̇o₂with Small Muscle Mass Exercise