Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study

Abstract

Objective To examine the relation between the normal range of serum aminotransferase concentration and mortality from liver disease. Design Prospective cohort study. Setting Korea Medical Insurance Corporation study with eight years' follow up. Participants 94 533 men and 47 522 women aged 35-59 years. Main outcome measure Mortality from liver diseases according to death certificate. Results There was a positive association between the aminotransferase concentration, even within normal range (35-40 IU/l), and mortality from liver disease. Compared with the concentration < 20 IU/l, the adjusted relative risks for an aspartate aminotransferase concentration of 20-29 IU/l and 30-39 IU/l were 2.5 (95% confidence interval 2.0 to 3.0) and 8.0 (6.6 to 9.8) in men and 3.3 (1.7 to 6.4) and 18.2 (8.1 to 40.4) in women, respectively, The corresponding risks for alanine aminotransferase were 2.9 (2.4 to 3.5) and 9.5 (7.9 to 11.5) in men and 3.8 (1.9 to 7.7) and 6.6 (1.5 to 25.6) in women, respectively. According to receiver operating characteristic curves the best cut-off values for the prediction of liver disease in men were 31 IU/l for aspartate aminotransferase and 30 IU/l for alanine aminotransferase. Conclusion People with slightly increased aminotransferase activity, but still within the normal range, should be closely observed and further investigated for liver diseases.

The Effect of Probiotic and/or Prebiotic on Liver Function Tests in Patients with Nonalcoholic Fatty Liver Disease: A Double Blind Randomized Clinical Trial

“…According to the study of Hyeon, the best cut-off values for the prediction of liver disease were 31 IU/L for aspartate aminotransferase and 30 IU/L for alanine aminotransferase (18). The detection method for fatty liver disease was an ultrasound of the liver and bile ducts and liver aminotransferases enzymes tests.…”

Clinical Trial Analysis of Different Stages of HBV Patients Treated with Human CIK Cells

“…The general tests for liver diseases detection is serum aminotransferase assays as the continuous enzyme concentration distribution in a population [31]. The marker of virus multiplication is serum hepatitis B virus (HBV) DNA level.…”

Hepatitis B Virus, Hepatitis C Virus Markers and Serum Alanine Amino-Transferase (ALT) Levels, in a Young Adult Population of Sylhet District

“…Several population-based studies have found slightly increased ALT levels within the current normal range to be closely related to comorbidities and mortality. [18][19][20] Current upper limit of normal (ULN) for ALT level were set, on average, ranging from 30 U/L to 50 U/L over the past 10 years. Such thresholds, however, vary tremendously among hospitals, research centers and geographic locations.…”

“…And the recommended ULN ALT was 30 U/L for men and 19 U/L for women respectively. 18,[22][23][24] Based on the previous results it is found that, recent ULN ALT greatly increase the number of asymptomatic patients with abnormal ALT values, and would identify more patients with nonalcoholic fatty liver disease (NAFLD) and clinically mild HBV/HCV infection.…”