“…Concomitant pro- and anti-inflammatory activity is complex, patient-related, and varies over time. Interpreting or manipulating post-insult immunosuppression definitely requires more insight in metabolic or endocrine pathways, neutrophil and macrophage behavior, epigenetic reprogramming, myeloid-derived suppressor cell activity, and processes of apoptotic and/or autophagic cellular “housekeeping” [ 10 ].…”