Normal Roles for Dietary Fructose in Carbohydrate Metabolism

Laughlin, Maren R.

doi:10.3390/nu6083117

Cited by 93 publications

(85 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fructose is often consumed in diets also rich in glucose and lipids. Although this carbohydrate is more harmful than glucose as it is more lipogenic and its metabolism differs from that of glucose [8,45], its effects are amplified when it is associated with glucose [82]. Indeed, fructose effects are more severe when consumed in the form of disaccharides (i.e., sucrose composed of equal parts of fructose and glucose) or associated with other macromolecules such as lipids [19,83].…”

Section: Specific or Indirect Effect Of Fructosementioning

confidence: 99%

Fructose and NAFLD: The Multifaceted Aspects of Fructose Metabolism

2017

View full text Add to dashboard Cite

Among various factors, such as an unhealthy diet or a sedentarity lifestyle, excessive fructose consumption is known to favor nonalcoholic fatty liver disease (NAFLD), as fructose is both a substrate and an inducer of hepatic de novo lipogenesis. The present review presents some well-established mechanisms and new clues to better understand the pathophysiology of fructose-induced NAFLD. Beyond its lipogenic effect, fructose intake is also at the onset of hepatic inflammation and cellular stress, such as oxidative and endoplasmic stress, that are key factors contributing to the progression of simple steatosis to nonalcoholic steatohepatitis (NASH). Beyond its hepatic effects, this carbohydrate may exert direct and indirect effects at the peripheral level. Excessive fructose consumption is associated, for example, with the release by the liver of several key mediators leading to alterations in the communication between the liver and the gut, muscles, and adipose tissue and to disease aggravation. These multifaceted aspects of fructose properties are in part specific to fructose, but are also shared in part with sucrose and glucose present in energy–dense beverages and foods. All these aspects must be taken into account in the development of new therapeutic strategies and thereby to better prevent NAFLD.

show abstract

Section: Specific or Indirect Effect Of Fructosementioning

confidence: 99%

Fructose and NAFLD: The Multifaceted Aspects of Fructose Metabolism

2017

View full text Add to dashboard Cite

show abstract

“…Studies have shown that high intake of sugar-sweetened soft drinks has the potential of increasing fasting blood glucose concentration and can predispose one to several disease states, including obesity, type-2 diabetes and cardiovascular disease (Gibson, 2008;Laughlin et al, 2014). Evidence from this study showed that human subjects fed regular coke had a significant increase (p< 0.05) in blood glucose concentration.…”

Section: Discussionmentioning

confidence: 58%

Effects of Regular Coke and Coke Zero on Blood Glucose, Serum Lipid Profile and Activities of Serum Aminotransferases in Healthy Human Subjects

2015

IJSR

View full text Add to dashboard Cite

Regular coke and Coke zero were investigated for possible effects on blood glucose concentration, serum lipid profile and activities of serum aminotransferases (AST and ALT) of healthy human subjects. Different groups of the human subjects were fed Eva premium table water (330ml), regular coke (330ml) or coke zero (330ml) each day for 4 days. Results obtained showed that regular coke fed group exhibited significantly high blood glucose concentration (p < 0.05) while coke zero and water fed groups showed no significant difference (p> 0.05). Also both regular coke and coke zero showed a decrease in serum high density lipoprotein cholesterol concentration (p< 0.05), an increase in serum total cholesterol concentration, low density lipoprotein cholesterol concentration and AST activity (p< 0.05), and a statistically non-significant effect (p> 0.05) on serum ALT activity and triglycerides. Blood glucose concentration is a marker of diabetes mellitus while a rise in the activities of AST and ALT in the bloodstream gives an indication of failure of vital organs such as the heart and liver. Abnormal lipid profile parameters gives an indication of predisposure to cardiovascular diseases such as atherosclerosis. From the findings of this study, it can be concluded that high intake of regular coke and coke zero can predispose one to some diseases, notably organ failure, diabetes mellitus and atherosclerosis.

show abstract

“…The absorption of fructose in the intestines increases if it is consumed together with other sugars or starch [55,78]. Consumption of fructose leads to the formation of the fructose-one-phosphate which activates hepatic glucokinase, and consequently increases the consumption of glucose in the liver [73,78]. It should be noted that the formation of the fructoseone-phosphate requires a large amount of ATP, so an excess of fructose in the food, can lead to a decrease in the hepatic content of ATP and intracellular inorganic phosphorus.…”

Section: Dietary Trend In Specialized Foods Developmentmentioning

confidence: 99%

“…Finally, there is evidence that fructose can indirectly affect glucosedependent insulin secretion, facilitating the release of glucagon-like peptide-1 (GLP-1) by the enteroendocrine L-cells of the small intestines [73]. GLP-1 possesses incretin activity, meaning it stimulates insulin release by the pancreas.…”

Section: Dietary Trend In Specialized Foods Developmentmentioning

confidence: 99%

Innovative Approaches in the Development of Specialized Food Products of Optimized Composition for Patients with Type 2 Diabetes

Va¹,

KhKh²,

Oa³

et al. 2016

J Diabetes Metab

View full text Add to dashboard Cite

Type 2 Diabetes Mellitus is a major medical, social and economic problem, due to the high prevalence and increasing incidence of the disease with subsequent progression of seriously disabling complications and need for specialized medical care. Globally, 382 million people have diabetes, and the number of people with the disease is set to rise beyond 592 million in less than 25 years. Diabetes caused 5.1 million deaths in 2013. Every six seconds a person dies from diabetes. Diabetic management is usually targeted at reducing weight, ameliorating glycemic control and reducing other risk factors that lead to vascular complications. Dietary intervention is considered a necessary part of the treatment of type 2 diabetes in addition to any glucose-lowering pharmacotherapy. The development of specialized foodstuffs with predetermined chemical composition is an important objective of clinical nutrition. This review provides medical and biological rationale for the use of food ingredients with benefits in the development of optimized food formulations for patients with type 2 diabetes. Key aspects of the development of specialized food products for patients with type 2 diabetes is to meet the physiological needs of the patient with foods containing biologically active substances which provide favorable metabolic effects and to be careful to preserve traditional hedonic qualities of the enriched product, which would be important for compliance and general product acceptability.

show abstract

Normal Roles for Dietary Fructose in Carbohydrate Metabolism

Cited by 93 publications

References 53 publications

Fructose and NAFLD: The Multifaceted Aspects of Fructose Metabolism

Fructose and NAFLD: The Multifaceted Aspects of Fructose Metabolism

Effects of Regular Coke and Coke Zero on Blood Glucose, Serum Lipid Profile and Activities of Serum Aminotransferases in Healthy Human Subjects

Innovative Approaches in the Development of Specialized Food Products of Optimized Composition for Patients with Type 2 Diabetes

Contact Info

Product

Resources

About