Normal right and left ventricular mass development during early infancy

Joyce, James J.; Dickson, Patricia I.; Qi, Ning; Noble, Julie E.; Raj, J. Usha; Baylen, Barry G.

doi:10.1016/j.amjcard.2003.11.063

Cited by 38 publications

(33 citation statements)

References 17 publications

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“…Left-right anatomical differences of the cerebral hemispheres have been detected by ultrasound scanning as early as 18 weeks postconception (8). In infants, the right hemisphere has been reported to develop functionally and anatomically earlier than the left hemisphere in various respects, including that left hemisphere language-related brain regions develop more slowly than their contralateral counterparts (9)(10)(11). These observations indicate a broadly lateralized program of motor and cognitive development that begins in utero in our species and suggest that a general model can involve different rates of maturation on the two sides of the central nervous system (CNS).…”

mentioning

confidence: 99%

Left–Right Asymmetry of Maturation Rates in Human Embryonic Neural Development

Kovel

Lisgo²,

Karlebach

et al. 2017

Biological Psychiatry

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BACKGROUND: Left-right asymmetry is a fundamental organizing feature of the human brain, and neuropsychiatric disorders such as schizophrenia sometimes involve alterations of brain asymmetry. As early as 8 weeks postconception, the majority of human fetuses move their right arms more than their left arms, but because nerve fiber tracts are still descending from the forebrain at this stage, spinal-muscular asymmetries are likely to play an important developmental role. METHODS: We used RNA sequencing to measure gene expression levels in the left and right spinal cords, and the left and right hindbrains, of 18 postmortem human embryos aged 4 to 8 weeks postconception. Genes showing embryonic lateralization were tested for an enrichment of signals in genome-wide association data for schizophrenia. RESULTS:The left side of the embryonic spinal cord was found to mature faster than the right side. Both sides transitioned from transcriptional profiles associated with cell division and proliferation at earlier stages to neuronal differentiation and function at later stages, but the two sides were not in synchrony (p 5 2.2 E-161). The hindbrain showed a left-right mirrored pattern compared with the spinal cord, consistent with the well-known crossing over of function between these two structures. Genes that showed lateralization in the embryonic spinal cord were enriched for association signals with schizophrenia (p 5 4.3 E-05). CONCLUSIONS: These are the earliest stage left-right differences of human neural development ever reported. Disruption of the lateralized developmental program may play a role in the genetic susceptibility to schizophrenia.

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mentioning

confidence: 99%

Left–Right Asymmetry of Maturation Rates in Human Embryonic Neural Development

Kovel

Lisgo²,

Karlebach

et al. 2017

Biological Psychiatry

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“…RV free-wall mass was calculated using end-diastolic measurements in the following previously validated formula: RV free-wall mass= 5.84 (RV cavity area) (RV free-wall thickness) + 1.0 (Joyce et al). 14,15 For comparing echocardiographic measures in subjects of differing body size, these measures were indexed to BSA to a power of 0.5 for a linear dimension) and to a power of 1 for area and mass (Gutgessel et al). 13 where ET is Ejection Time and PI is Pulse Interval expressed in seconds (Joyce et al).…”

Section: Methodsmentioning

confidence: 99%

“…13 The apical 4-chamber view was used to measure the RV cavity cross-sectional area by tracing the endocardial border (Joyce et al). 14,15 RV free-wall thickness at end-diastole was measured from either the subcostal, coronal or parasternal-axis view, whichever view most clearly illustrated the RV epicardium and endocardium. RV free-wall mass was calculated using end-diastolic measurements in the following previously validated formula: RV free-wall mass= 5.84 (RV cavity area) (RV free-wall thickness) + 1.0 (Joyce et al).…”

Section: Methodsmentioning

confidence: 99%

“…13 where ET is Ejection Time and PI is Pulse Interval expressed in seconds (Joyce et al). 15 The peak instantaneous pressure gradient of Tricuspid Regurgitation (TR) was determined from the maximal continuous-wave Doppler velocity and the simplified Bernoulli equation (Abaci et al). 16 RESULTS  Out of the total 138 cases, 84 (60.86%) were sickle cell trait (AS) and 54 (39.14%) were sickle cell disease (SS).…”

Section: Methodsmentioning

confidence: 99%

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Echocardiographic Study of Right Ventricular Abnormalities in Adult Patients of Sickle Cell Anaemia

Ahmad¹,

Toppo²,

Varma³

2017

jemds

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BACKGROUNDSickle Cell Disorder (SCD) is the first diagnosed disease that was linked to the haemoglobin protein. It is an autosomal recessive disorder that occurs throughout the world. The cardiac effects of this chronic illness on the left ventricle have been extensively investigated in adults. However, fewer adult studies and only one study that included adolescents have investigated any aspect of the impact of SCA on the Right Ventricle (RV).

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“…The left ventricle, defined as left ventricular free wall+interventricular septum (Fulton et al, 1952;Joyce et al, 2004;Keen, 1955), was separated from the remainder of the heart and weighed to either 0.1 mg (ventricles<30 g; AE163, Mettler, Greifensee, Switzerland) or 1.0 mg (>30 g; 1265 MP, Sartorius, Göttingen, Germany). The left ventricle was bisected along the mid-equator, and random linear measurements of transmural wall thickness (×4), and inner (×2) and outer (×2) diameters were taken with digital callipers to 0.01 mm.…”

Section: Left Ventricle Mass and Geometrymentioning

confidence: 99%

Scaling of left ventricle cardiomyocyte ultrastructure across development in the kangaroo Macropus fuliginosus

Snelling

Taggart

Maloney

et al. 2015

Journal of Experimental Biology

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The heart and left ventricle of the marsupial western grey kangaroo Macropus fuliginosus exhibit biphasic allometric growth, whereby a negative shift in the trajectory of cardiac growth occurs at pouch exit. In this study, we used transmission electron microscopy to examine the scaling of left ventricle cardiomyocyte ultrastructure across development in the western grey kangaroo over a 190-fold body mass range (0.355−67.5 kg). The volume-density (%) of myofibrils, mitochondria, sarcoplasmic reticuli and T-tubules increase significantly during in-pouch growth, such that the absolute volume (ml) of these organelles scales with body mass (M b ; kg) with steep hyperallometry: , respectively. The steep hyperallometry of organelle volumes and volume-densities across in-pouch growth is consistent with the improved contractile performance of isolated cardiac muscle during fetal development in placental mammals, and is probably critical in augmenting cardiac output to levels necessary for endothermy and independent locomotion in the young kangaroo as it prepares for pouch exit. The shallow hypoallometry of organelle volumes during post-pouch growth suggests a decrease in relative cardiac requirements as body mass increases in free-roaming kangaroos, which is possibly because the energy required for hopping is independent of speed, and the capacity for energy storage during hopping could increase as the kangaroo grows.

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Normal right and left ventricular mass development during early infancy

Cited by 38 publications

References 17 publications

Left–Right Asymmetry of Maturation Rates in Human Embryonic Neural Development

Left–Right Asymmetry of Maturation Rates in Human Embryonic Neural Development

Echocardiographic Study of Right Ventricular Abnormalities in Adult Patients of Sickle Cell Anaemia

Scaling of left ventricle cardiomyocyte ultrastructure across development in the kangaroo Macropus fuliginosus

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