Normal reference values for mitral annular plane systolic excursion by motion-mode and speckle tracking echocardiography: a prospective, multicentre, population-based study

Abstract

Aims Mitral annular plane systolic excursion (MAPSE) is a simple and reliable index for evaluating left ventricular (LV) systolic function, particularly in patients with poor image quality; however, the lack of reference values limits its widespread use. This study aimed to establish the normal ranges for MAPSE measured using motion mode (M-mode) and two-dimensional speckle-tracking echocardiography (2D-STE) and to explore its principal determinants. Methods and results This multicenter, prospective, cross-sectional study included 1,952 healthy participants (840 men [43%]; age range, 18–80 years) from 55 centers. MAPSE was measured using M-mode echocardiography and 2D-STE. The results showed that women had a higher MAPSE than men and MAPSE decreased with age. The age- and sex-specific reference values for MAPSE were established for these two methods. Multiple linear regression analyses revealed that MAPSE on M-mode echocardiography correlated with age and MAPSE on 2D-STE with age, blood pressure, heart rate, and LV volume. Moreover, MAPSE measured by 2D-STE correlated more strongly with global longitudinal strain compared with that measured using M-mode echocardiography. Conclusion Normal MAPSE reference values were established based on age and sex. Blood pressure, heart rate, and LV volume are potential factors that influence MAPSE and should be considered in clinical practice. Normal values are useful for evaluating the LV longitudinal systolic function, especially in patients with poor image quality, and may further facilitate the use of MAPSE in routine assessments.

Longitudinal Cardiac Evaluation of Children with Multisystem Inflammatory Syndrome (MIS-C) Following COVID-19 by Conventional and Speckle-Tracking Echocardiography

“…Furthermore, the evaluation of diastolic function and the STE-GLS analysis were performed only in a subset of the participants. Regarding the limitations of the echocardiographic methods used in the study, M-mode echocardiography is limited by angle-dependency, while the main limitation of STE is intervendor variability [ 50 , 51 ]. Moreover, interobserver and intraobserver variability were not assessed in our study.…”

Feasibility and prognostic value of tissue motion annular displacement in patients with heart transplantation

“…12,13 Previous studies have demonstrated the utility of TMAD in estimating the LV function in healthy population or patients with cardiac diseases. [14][15][16][17][18][19][20] However, there are no studies exploring the feasibility of TMAD in HT patients, and the predictive value of this parameter for adverse outcomes in these patients remains unknown. We hypothesized that like LVGLS, TMAD measurement would provide important prognostic information for HT patients.…”