Normal ranges of non-fasting triglycerides in healthy Dutch males and females

Wijk, J.P.H. van; Oostrom, A. J. H. H. M. Van; Cabezas, Manuel Castro

doi:10.1016/j.cccn.2003.07.014

Cited by 11 publications

(10 citation statements)

References 31 publications

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“…Similar results have been obtained in our laboratory [2,21]. Capillary TG concentrations are generally 0.2–0.3 mmol/L higher than TG concentrations in venous plasma [25], which may reflect differences between capillary and venous samples or differences in methodology.…”

Section: Methodssupporting

confidence: 83%

“…Subjects were healthy male volunteers or patients, aged from 18 to 80 years, with hyperlipidemia, a known medical history of cardiovascular disease (CVD) or type 2 diabetes mellitus (T2DM) participating in several clinical studies with the same protocol, aimed at investigating factors influencing postprandial lipemia [2,21,22,23,24,25]. Exclusion criteria were the presence of renal, liver or thyroid disease.…”

Section: Methodsmentioning

confidence: 99%

“…In this observational study we investigated the impact of alcohol consumption on capillary TG concentrations (cTG) during the day determined in free living male subjects, using a hand-held point-of-care testing device [2,21,22,23,24,25]. …”

Section: Introductionmentioning

confidence: 99%

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Diurnal Triglyceridemia in Relation to Alcohol Intake in Men

et al. 2013

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Fasting and postprandial triglyceride concentrations largely depend on dietary and lifestyle factors. Alcohol intake is associated with triglycerides, but the effect of alcohol on diurnal triglyceridemia in a free living situation is unknown. During three days, 139 men (range: 18–80 years) measured their own capillary triglyceride (cTG) concentrations daily on six fixed time-points before and after meals, and the total daily alcohol intake was recorded. The impact of daily alcohol intake (none; low, <10 g/day; moderate, 10–30 g/day; high, >30 g/day) on diurnal triglyceridemia was analyzed by the incremental area under the cTG curve (∆cTG-AUC) reflecting the mean of the six different time-points. Fasting cTG were similar between the alcohol groups, but a trend of increased cTG was observed in men with moderate and high alcohol intake after dinner and at bedtime (p for trend <0.001) which persisted after adjustment for age, smoking and body mass index. The ∆cTG-AUC was significantly lower in males with low alcohol intake (3.0 ± 1.9 mmol·h/L) (n = 27) compared to males with no (7.0 ± 1.8 mmol·h/L) (n = 34), moderate (6.5 ± 1.8 mmol·h/L) (n = 54) or high alcohol intake (7.2 ± 2.2 mmol·h/L) (n = 24), when adjusted for age, smoking and body mass index (adjusted p value < 0.05). In males, low alcohol intake was associated with decreased diurnal triglyceridemia, whereas moderate and high alcohol intake was associated with increased triglycerides after dinner and at bed time.

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Section: Methodssupporting

confidence: 83%

Section: Methodsmentioning

confidence: 99%

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Diurnal Triglyceridemia in Relation to Alcohol Intake in Men

et al. 2013

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“…This is analogous to adjustments suggested by other investigators [22,23]. To that end, we used time-specific percentiles for participants with normal birth weight corresponding to the cut-off level used in the metabolic syndrome definition.…”

Section: Definitionsmentioning

confidence: 99%

Intrauterine growth restriction: no unifying risk factor for the metabolic syndrome in young adults

Euser

Dekker

Hallan

2009

European Journal of Cardiovascular Prevention & Rehabilitat

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“…Among the different methodologies used to assess postprandial TG concentrations, namely, oral fat tolerance tests and serial measurements of capillary TG concentrations thought the day, it is of note that the latter reflects TG changes in typical living conditions (3 ). Serial daylong TG profiles reveal important metabolic disturbances in certain groups of patients (9 -13 ), and intraindividual variability is far smaller for daylong TG profiles than for fasting plasma TG values (10,14 ).…”

mentioning

confidence: 99%

Additive Effects of the PPARγ, APOE, and FABP-2 Genes in Increasing Daylong Triglycerides of Normolipidemic Women to Concentrations Comparable to Those in Men

et al. 2005

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Background: Fasting and postprandial triglyceride (TG) concentrations vary considerably among individuals. TG metabolism is more efficient in women than in men, which may partly explain why females are protected against atherosclerosis. Our aim was to identify genderspecific genetic influences on fasting and postprandial TG concentrations under typical living conditions in healthy, lean, normolipidemic women. Methods: We studied 40 women and 48 men. Diurnal capillary TG profiles were calculated as the integrated area under the capillary TG curve averaged over 3 days. Genotypes of the FABP-2, HL, LPL, APOE, and PPAR␥ genes and the APOC-III, APOC-III/A-IV intergenic region were determined. Results: Three genes (FABP-2, APOE, and PPAR␥) had a significant additive effect only in women. Mean TG concentrations were fourfold higher in women carriers of the PPAR␥ wild-type allele (P ‫؍‬ 0.044), threefold higher in carriers of the rare FABP-2 allele (P ‫؍‬ 0.006), and fivefold higher in carriers of the E2 allele of the APOE gene (P ‫؍‬ 0.037) than in noncarriers. None of these effects was observed in men. The presence of two or more of these adverse alleles increased TG concentrations in a dose-dependent manner. Women carriers of three adverse alleles had postprandial TG values comparable to those for men.

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Normal ranges of non-fasting triglycerides in healthy Dutch males and females

Cited by 11 publications

References 31 publications

Diurnal Triglyceridemia in Relation to Alcohol Intake in Men

Diurnal Triglyceridemia in Relation to Alcohol Intake in Men

Intrauterine growth restriction: no unifying risk factor for the metabolic syndrome in young adults

Additive Effects of the PPARγ, APOE, and FABP-2 Genes in Increasing Daylong Triglycerides of Normolipidemic Women to Concentrations Comparable to Those in Men

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