Normal pulmonary function measurements and airway reactivity in childhood after mild bronchiolitis

McConnochie, Kenneth M.; Mark, John; McBride, John T.; Hall, William J.; Brooks, John; Klein, Suzanne J.; Miller, Robert L.; McInerny, Thomas K.; Nazarian, Lawrence F.; MacWhinney, James B.

doi:10.1016/s0022-3476(85)80614-4

Cited by 57 publications

(13 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…25 In contrast, an earlier study of mild bronchiolitis demonstrated no evidence of heightened airway hyperresponsiveness 8 to 12 years later. 26 Therefore it appears that severe bronchiolitis is associated with subsequent airway hyperresponsiveness but not necessarily related to the diagnosis of asthma. The long-term consequences of this finding might be the development of asthma in additional subjects because airway hyperresponsiveness at age 6 years has been demonstrated to be a risk factor of newly diagnosed asthma in early adulthood.…”

Section: Discussionmentioning

confidence: 99%

Determinants of asthma after severe respiratory syncytial virus bronchiolitis

Bacharier

Cohen

Schweiger

et al. 2012

Journal of Allergy and Clinical Immunology

230

240

View full text Add to dashboard Cite

Background The development of asthma after respiratory syncytial virus (RSV) bronchiolitis has been demonstrated in case-control studies, although the determinants of post-RSV asthma remain undefined. Objectives We sought to evaluate the potential determinants of physician-diagnosed asthma after severe RSV bronchiolitis during infancy. Methods We enrolled 206 children during an initial episode of severe RSV bronchiolitis at 12 months of age or less in a prospective cohort study and followed these children for up to 6 years. In a subset of 81 children, we analyzed CCL5 (RANTES) mRNA expression in upper airway epithelial cells. Results Forty-eight percent of children had physician-diagnosed asthma before the seventh birthday. Independent determinants significantly associated with increased risk for physician-diagnosed asthma by the seventh birthday included maternal asthma (odds ratio [OR], 5.2; 95% CI, 1.7-15.9; P = .004), exposure to high levels of dog allergen (OR, 3.2; 95% CI, 1.3-7.7; P = .012), aeroallergen sensitivity at age 3 years (OR, 10.7; 95% CI, 2.1-55.0; P = .005), recurrent wheezing during the first 3 years of life (OR, 7.3; 95% CI, 1.2-43.3; P = .028), and CCL5 expression in nasal epithelia during acute RSV infection (OR, 3.8; 95% CI, 1.2-2.4; P < .001). White children (OR, 0.19; 95% CI, 0.04-0.93; P = .041) and children attending day care (OR, 0.18; 95% CI, 0.04-0.84; P = .029) had a decreased risk of physician-diagnosed asthma. Conclusions Approximately 50% of children who experience severe RSV bronchiolitis have a subsequent asthma diagnosis. The presence of increased CCL5 levels in nasal epithelia at the time of bronchiolitis or the development of allergic sensitization by age 3 years are associated with increased likelihood of subsequent asthma.

show abstract

Section: Discussionmentioning

confidence: 99%

Determinants of asthma after severe respiratory syncytial virus bronchiolitis

Bacharier

Cohen

Schweiger

et al. 2012

Journal of Allergy and Clinical Immunology

230

240

View full text Add to dashboard Cite

show abstract

“…Studies of the outcome of bronchiolitis during infancy have included studies that evaluated the effects of ribavirin therapy during acute illness on the long-term sequelae of recurrent wheezing during childhood (101,132,208,240,256,310), with promising results. In contrast, Krilov et al (217) found no differences between ribavirin-treated and untreated infants in wheezing or other pulmonary function measures 6 to 8 years beyond their infection.…”

Section: Therapy For Hrsv Diseasementioning

confidence: 99%

Animal Pneumoviruses: Molecular Genetics and Pathogenesis

2004

View full text Add to dashboard Cite

Pneumoviruses are single-stranded, negative-sense, nonsegmented RNA viruses of the family Paramyxoviridae, subfamily Pneumovirinae, and include pathogens that infect humans (respiratory syncytial virus and human metapneumovirus), domestic mammals (bovine, ovine, and caprine respiratory syncytial viruses), rodents (pneumonia virus of mice), and birds (avian metapneumovirus). Among the topics considered in this review are recent studies focused on the roles of the individual virus-encoded components in promoting virus replication as well as in altering and evading innate antiviral host defenses. Advances in the molecular technology of pneumoviruses and the emergence of recombinant pneumoviruses that are leading to improved virus-based vaccine formulations are also discussed. Since pneumovirus infection in natural hosts is associated with a profound inflammatory response that persists despite adequate antiviral therapy, we also review the recent experimental treatment strategies that have focused on combined antiviral, anti-inflammatory, and immunomodulatory approaches

show abstract

“…However, in mild cases there seemed to be no hyperresponsiveness present at 8-12 yrs follow-up [72,73].…”

Section: Postbronchiolitis Effects On Hyperresponsiveness and Lung Fumentioning

confidence: 99%

Relationship between respiratory syncytial virus bronchiolitis and future obstructive airway diseases

Wennergren¹,

Kristjánsson²

2001

European Respiratory Journal

View full text Add to dashboard Cite

Relationship between respiratory syncytial virus bronchiolitis and future obstructive airway diseases. G. Wennergren, S. Kristjánsson. #ERS Journals Ltd 2001. ABSTRACT: Evidence from a large number of prospective case-control studies shows that respiratory syncytial virus (RSV) bronchiolitis in infancy is often associated with recurrent wheezing and asthma during subsequent years. However, wheezing tends to diminish and most studies show no significant increase in wheezing compared to controls by school age or adolescence. An unresolved question is whether severe RSV infection during infancy causes the respiratory sequelae or inherent abnormalities predispose an infant to develop severe respiratory infection and sequelae, i.e. RSV is associated with the development of pulmonary sequelae.Studies on long-term outcome of RSV bronchiolitis are reviewed from an evidencebased perspective.The majority of prospective placebo-controlled studies do not show any long-term beneficial effects of corticosteroid treatment, i.e. the risk of subsequent wheezing is not diminished by the treatment. The evidence for an increased risk of allergic sensitization after RSV bronchiolitis is not nearly as strong as the evidence for an increased risk of subsequent wheezing. In fact, most studies do not show any significant increase in atopy after RSV bronchiolitis. This suggests that the increased risk of wheezing after RSV is not linked to an increased risk of atopy. There are some indications that infants who develop severe RSV and subsequent wheezing may have aberrations that predate the RSV infection.To decide whether respiratory syncytial virus bronchiolitis causes, or is associated with the respiratory sequelae (or with subsequent allergy), it will be necessary to conduct prospective, randomized studies, where the cytokine profile prior to bronchiolitis onset is known. Such studies should preferably include some form of intervention against respiratory syncytial virus. A more complete understanding of the risk factors for severe respiratory syncytial virus infection and the role of respiratory syncytial virus infection in the initiation of asthma is needed as a basis for large-scale and cost-effective programmes to prevent respiratory syncytial virus-related morbidity. Eur Respir J 2001; 18: 1044-1058. Respiratory syncytial virus (RSV) bronchiolitis is the most common, severe lower respiratory tract infection in infancy. It now seems well established that RSV bronchiolitis in infancy is associated with recurrent wheezing and asthma during the first decade of life. In some children, wheezing after early lower airway infection with RSV is transient, but in many of the children RSV-induced bronchiolitis represents the onset of asthma. In fact, there are results which indicate that severe RSV bronchiolitis in the young infant may shift the T-helper (Th)1/Th2 balance in favour of a Th2 cytokine pattern, leading to development of allergic sensitization and persistent asthma [1,2]. However, the association with risk of development of atopy...

show abstract

Normal pulmonary function measurements and airway reactivity in childhood after mild bronchiolitis

Cited by 57 publications

References 13 publications

Determinants of asthma after severe respiratory syncytial virus bronchiolitis

Determinants of asthma after severe respiratory syncytial virus bronchiolitis

Animal Pneumoviruses: Molecular Genetics and Pathogenesis

Relationship between respiratory syncytial virus bronchiolitis and future obstructive airway diseases

Contact Info

Product

Resources

About