Normal pregnancy and successful delivery in myophosphorylase deficiency (McArdle's disease)

Cochrane, Peter; Alderman, Brian

doi:10.1136/jnnp.36.2.225

Cited by 19 publications

(22 citation statements)

References 6 publications

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“…In a series of 20 pregnancies in 14 women, published in 2010, an improvement was seen in 13 of the patients 7 . Two other individually described cases also improved during pregnancy 5,6 . There are more pregnancies described, but there is not enough data to know if there was an improvement of the symptoms [8][9][10][11][12] .…”

Section: Discussionmentioning

confidence: 83%

“…There are more pregnancies described, but there is not enough data to know if there was an improvement of the symptoms [8][9][10][11][12] . Pregnancy is not defined as a risk factor in McArdle disease and normal delivery is not contraindicated [5][6][7][8] .…”

Section: Discussionmentioning

confidence: 99%

“…The reported case illustrates these situations, where the patients frequently ignore the symptoms. Also, there are only a few described cases of pregnancy and labour in patients with McArdle disease [5][6][7][8][9][10][11][12] . Therefore, the fact that this patient had two pregnancies can be helpful to understand the behaviour of this disease during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

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McArdle Disease and Pregnancy

Melo¹,

Gomes²,

Leite³

et al. 2015

Gal. Clin.

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ABSTRACT:McArdle disease (Glycogen Storage Disease type V) is a rare hereditary disease, frequently diagnosed in adulthood. It is associated with exercise intolerance and severe rhabdomyolysis. There are only a few reported cases of pregnancy in these patients, and in most of them there was no worsening of the disease. The authors report the case of a young woman presenting with severe rhabdomyolysis by the age of 28, being diagnosed with McArdle. She complained about exercise intolerance since childhood, but never had valued these symptoms. The authors also describe two pregnancies in the same patient. During the first pregnancy, there was improvement of the patient's complaints, but it was not observed during the second one. The basis of the therapy of this disease consists of aerobic exercise and ensuring euglycaemia and enough protein intake. With these measures, it is possible to control the symptoms and complications of the disease.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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McArdle Disease and Pregnancy

Melo¹,

Gomes²,

Leite³

et al. 2015

Gal. Clin.

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“…A woman with McArdle's disease bore a child without adverse consequences to herself or her child. 27 Coleman discussed techniques for safe general anesthesia for caesarian section in another woman with McArdle's disease. 30 A patient with myoadenylate deaminase deficiency had an uncomplicated labor and delivery.…”

Section: Inherited Disorders Of Nerve and Muscle Complicating Pregnancymentioning

confidence: 99%

Neuromuscular disorders in pregnancy

Sax

Rosenbaum

2006

Muscle and Nerve

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Many neuromuscular conditions occur more frequently during pregnancy and include carpal tunnel syndrome, Bell's palsy, lumbosacral radiculopathy, meralgia paresthetica, intercostal neuralgia, and other compression neuropathies. Preexisting or coincident neuromuscular diseases, including demyelinating polyneuropathies, inflammatory muscle disease, myasthenia gravis, and inherited nerve and muscle disease present specific problems during pregnancy. We review management of neuromuscular disorders during pregnancy, labor, delivery, and the early postpartum period.

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“…The first report of pregnancy and labour in a woman with McArdle disease was in 1973 and the authors of that paper were able to discuss the options of management with Dr McArdle. 5 Their patient progressed to a Keilland's forceps delivery. A further report in 1984 described a woman who underwent caesarean section with general anaesthesia in labour at 33 weeks for hypertension and suspected intrauterine growth failure.…”

Section: Discussionmentioning

confidence: 99%

Myophosphorylase deficiency (McArdle disease) in a patient with normal pregnancy and normal pregnancy outcome

Giles

Maher

2011

Obstet Med

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Summary:McArdle disease is a rare, mostly autosomal recessive disorder of deficient myophosphorylation of glycogen in skeletal muscles. Recent knowledge regarding this condition means that women of childbearing age with McArdle disease can expect to labour normally without ill effect. We report a case of a 30-year-old woman in her first pregnancy who had an episode of exerciseinduced myoglobinuria with a significant rise in serum creatine kinase (CK) levels in early pregnancy who then laboured normally but did require a caesarean section for a malposition of the fetal head.

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Normal pregnancy and successful delivery in myophosphorylase deficiency (McArdle's disease)

Cited by 19 publications

References 6 publications

McArdle Disease and Pregnancy

McArdle Disease and Pregnancy

Neuromuscular disorders in pregnancy

Myophosphorylase deficiency (McArdle disease) in a patient with normal pregnancy and normal pregnancy outcome

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