Normal ocular flora in healthy eyes from a rural population in Sierra Leone

Capriotti, Joseph; Pelletier, Jesse; Shah, Mahendra; Caivano, D. M.; Ritterband, David C.

doi:10.1007/s10792-008-9196-4

Cited by 63 publications

(48 citation statements)

References 12 publications

(23 reference statements)

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“…[28,[34][35][36] mentioned earlier, there is a large variation of culture-positive rate in the studies of healthy eyes (47-95%) as well as diseased eyes. [6,14,28,34,35,37] In this study, the positive culture rate in patients with PBSCT-related dry eye and in nonhematopoietic transplantation-related dry eye patients were even lower than that of healthy eyes in the previous study. The difference in the culture methodology and different culture locations may explain the variation.…”

Section: Discussioncontrasting

confidence: 47%

Study of Conjunctival Flora in Patients after Peripheral Blood Stem Cell Transplantation and its Correlation with Tear Secretion

Chen¹,

Kuo²,

Wang³

et al. 2012

Biomedical

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Scientific background of the subjectDry eye occurs in 40-76% of post-peripheral blood stem cell transplantation (PBSCT) patients. The rate of positive conjunctival swab cultures in dry eye patients increases when compared with normal control, and the mean bacterial count is positively correlated with the reduction in goblet cells. What this study adds to the fieldThere is a positive correlation between the colonization rate and the severity of dry eye in post-PBSCT patients.Coagulase-negative Staphylococci is the most common colonizing bacteria of the ocular surface in both the normal population and post-PBSCT patients. The spectrum of conjunctival flora is independent of patient immune status.Background: Dry eye is a major ocular complication of peripheral blood stem cell transplantation (PBSCT) and may predispose bacterial colonization to the conjunctiva. To investigate the conjunctival bacterial flora in patients receiving PBSCT, we encompassed patients who received PBSCT at least 1 year from 2002 to 2008 in this cross-sectional study. Methods:Patients were divided into three groups in accordance to the result of the Schirmer Ia test. In the control group, we enrolled dry-eye patients with underlying disease other than hematopoietic stem cell transplantation of which the age range was similar to the study group. Results:Thirty-six patients with 72 eyes were included in our study. The culture rates were 22% (8 in 36) in the first group (Schirmer Ia= 0-5 mm), 20% (4 in 20) in the second group (Schirmer Ia= 6-9 mm), and 0% (n=16) in the third group (Schirmer Ia ≧ 10 mm). The flora in patients receiving PBSCT were coagulase-negative Staphylococci, Staphylococcus aureus and Corynebacterium sp. The bacterial colonization rate in the post-PBSCT group was not higher than the control group (22.2% vs. 30.8%), and coagulase-negative Staphylococci was the most common flora in the control group. Conclusions: In conclusion, despite not having statistical significance, there seems to be a positive correlation between the colonization rate and the severity of dry eye. However, bacterial profile isolated in post-PBSCT patients is not significantly different from other dry eye patients. (Biomed J 2012;35:493-99)

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Section: Discussioncontrasting

confidence: 47%

Study of Conjunctival Flora in Patients after Peripheral Blood Stem Cell Transplantation and its Correlation with Tear Secretion

Chen¹,

Kuo²,

Wang³

et al. 2012

Biomedical

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“…The most common bacterial isolates were S. albus (32%) followed by S. aureus (28%) (Tomar et al, 1971). In another study from Masungbo, Sierra Leone where analysis of conjunctival swabs obtained from healthy eyes of 276 residents showed presence of coagulase-negative staphylococci (28.6%), fungus (26.0%) and S. aureus (19.9%) (Capriotti et al, 2009). Many studies have not speciated the staphylococci from normal lids and conjunctiva, however, S. epidermidis is reported to be the most common species (McCulley et al, 1982).…”

Section: Staphylococcus In Wound and Eye Infectionsmentioning

confidence: 93%

Staphylococcal Infection, Antibiotic Resistance and Therapeutics

Choudhury¹,

Panda²,

Sharma³

et al. 2012

Antibiotic Resistant Bacteria - A Continuous Challenge in the New Millennium

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“…The microbiota cultured on the ocular surface can be determined using swab samples from conjunctiva, capsules, and tears (16)(17)(18)(19). Sticks of cotton or calcium alginate may be used for conjunctival swab specimens.…”

Section: Traditional Culture Methodsmentioning

confidence: 99%

“…The overall conclusion is that coagulase-negative staphylococci are the most common bacteria isolated from the conjunctiva, cap, or tears and are positive in about half of the cases (16)(17)(18). The next most common isolated microorganisms are Propionibacterium and diphtheroid bacteria (mostly Corynobacterium).…”

Section: Traditional Culture Methodsmentioning

confidence: 99%

Ocular Microbiota

Ayyıldız¹

2017

Med J Islamic World Acad Sci

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SUMMARYOne of the most prominent of recent developments is the understanding of human microbiota. Microbiota is a group of microbes settled in a specific area, while microbial describes the total genome of these bacteria. The 10 trillion germs, equivalent to 10 times the total number of cells in the human body, live only in the intestines. The ocular surface is in constant contact with the external environment and has been shown to have a unique flora. The diversity, detection methods, and influence of this fluorophore on ocular immunity, personality, and extrinsic factors have been investigated and improved. Specific treatment of patients, planning of systemic and topical antibiotics, and perhaps ocular flora transplantation are the aims of future studies.

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Normal ocular flora in healthy eyes from a rural population in Sierra Leone

Abstract: There is a high prevalence of fungal and bacterial colonization of healthy eyes in a rural population of Sierra Leone. A relationship may exist between resident normal flora and the etiology of ocular infections.

Cited by 63 publications

References 12 publications

Study of Conjunctival Flora in Patients after Peripheral Blood Stem Cell Transplantation and its Correlation with Tear Secretion

Study of Conjunctival Flora in Patients after Peripheral Blood Stem Cell Transplantation and its Correlation with Tear Secretion

Staphylococcal Infection, Antibiotic Resistance and Therapeutics

Ocular Microbiota

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