Normal Lumbar Vertebrae: Anatomic, Age, and Sex Variance in Subjects at Proton MR Spectroscopy—Initial Experience

Schellinger, Dieter; Lin, Chin-Shoou; Fertikh, Djamil; Lee, Jacob S.; Lauerman, William C.; Henderson, Fraser; Davis, Bolivia

doi:10.1148/radiology.215.3.r00jn42910

Cited by 113 publications

(105 citation statements)

References 33 publications

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“…The rate at which bone marrow conversion takes place is generally slower in the central compared with the peripheral skeleton (29). The fat content, which progresses gradually with a 7% increase per decade, reaches a balanced ratio of fat to hematopoietic marrow in the 50-year-old subject (30,31). Our study population was relatively elderly compared with the younger populations in the studies by Pache et al and Guggenberger et al However, further research is needed to determine optimal parameter settings for the reconstruction of noncalcium images under different circumstances.…”

Section: Musculoskeletal Imaging: Bone Marrow Edema In Vertebral Compmentioning

confidence: 99%

Bone Marrow Edema in Vertebral Compression Fractures: Detection with Dual-Energy CT

Wang

Tsai

Chuang³

et al. 2013

Radiology

155

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Purpose:To assess the use of the dual-energy computed tomographic (CT) virtual noncalcium technique in the evaluation of bone marrow edema in vertebral compression fractures. Materials and Methods:This prospective study was approved by the institutional review board; informed consent was obtained from all patients. Sixty-three consecutive patients with 112 thoracic and/or lumbar vertebral compression fractures were studied between January 2011 and April 2012. All patients underwent both dual-energy CT (100 kV and Sn140 kV, where Sn indicates the use of a 0.4-mm tin filter) and magnetic resonance (MR) imaging. Dual-energy CT data were postprocessed by using a three-material decomposition algorithm for generating noncalcium images of the collapsed bodies. Two radiologists evaluated for the presence of abnormal attenuation alterations in the bone marrow by using color-coded maps and measured CT numbers on noncalcium grayscale images. Bone sclerosis and intravertebral air were evaluated with CT scans. MR images served as the reference standard. CT numbers were subjected to receiver operating characteristic curve analysis. Results:MR imaging depicted 46 edematous and 66 nonedematous vertebral compression fractures. Eighty-two bodies were classified as having less than 50% sclerosis and/or air. Significant differences in noncalcium CT numbers between edematous and nonedematous vertebral compression fractures were found for both readers (P , .0001).CT numbers for the diagnosis of bone marrow edema on the basis of MR imaging revealed areas under the receiver operating characteristic curve of 0.799 and 0.841 for readers 1 and 2, respectively (P = .56). Use of a cutoff value of 280 to differentiate edematous vertebral bodies resulted in a sensitivity of 96.3%, specificity of 98.2%, and accuracy of 97.6% in the group of vertebral bodies with less than 50% sclerosis and/or air. Conclusion:Dual-energy CT virtual noncalcium images were able to depict bone marrow in the collapsed vertebral bodies, especially in those with less than 50% sclerosis and/or air.q RSNA, 2013

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Section: Musculoskeletal Imaging: Bone Marrow Edema In Vertebral Compmentioning

confidence: 99%

Bone Marrow Edema in Vertebral Compression Fractures: Detection with Dual-Energy CT

Wang

Tsai

Chuang³

et al. 2013

Radiology

155

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“…Relative vertebral fat content can be estimated from the peak LWR. The fat fraction (FF) is derived from the formula: FF ϭ peak LWR/(peak LWR ϩ 1) (14). The area under the peak of the lipid or water signals was measured by the Lorentzian curve-fitting procedure.…”

Section: H Mrs Measurementsmentioning

confidence: 99%

“…Proton MR spectroscopy ( 1 H MRS) can analyze the contents of bone marrow components quantitatively (8 -11). The lipid and water contents of normal and aging bone marrow have been successfully evaluated by the 1 H MRS (12)(13)(14)(15). De Bisschop et al (12) evaluated the fat fraction of bone marrow by MR methods and found a systemic increase in measured fat percentage of about 7% per decade of age.…”

mentioning

confidence: 99%

“…Kugel et al (13) used the PRESS technique to estimate the relative fat proton and also demonstrated the fat proportion increase with age from 24% in the 11-to 20-year-old age group to 54% in the age group older than 61 years. Schellinger et al (14) disclosed an agedependent increase in lumbar fat content by using 1 H MRS. Thus, 1 H MRS was considered as an accurate and efficient tool for in vivo analysis of the bone marrow lipid component.…”

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confidence: 99%

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Correlation between the bone marrow blood perfusion and lipid water content on the lumbar spine in female subjects

Chen

Shih

2006

Magnetic Resonance Imaging

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Purpose: To assess the marrow lipid water ratio (LWR) and spectral line width (LW) of lumbar vertebra by proton MR spectroscopy ( 1 H MRS) and correlate with the marrow blood perfusion (MBP) by contrast-enhanced dynamic MRI (dMRI) in female subjects. Materials and Methods:A total of 50 female subjects were included. Single-voxel 1 H MRS was measured at the L3 vertebrae. In the dMRI study, the maximum enhancement percentage (E max ) and enhancement slope were calculated from time-intensity curves. Pearson's correlation was calculated to explore the association of 1 H MRS, age, and perfusion parameters. Partial correlation was then used to control confounder effect.Results: LWR was negatively correlated with E max (r ϭ -0.72; P Ͻ 0.0001), but positively correlated with age (r ϭ 0.63; P Ͻ 0.0001 ). Lipid LW was negatively correlated with age (r ϭ -0.33; P Ͻ0.05), but positively correlated with E max (r ϭ 0.4; P Ͻ 0.05). After adjusting for the age effect by partial correlation, marrow LWR still negatively correlated with E max (r ϭ -0.63; P Ͻ 0.0001). After adjusting for the E max effect, marrow LWR still positively correlated with age (r ϭ 0.37; P Ͻ 0.05). Conclusion:After controlling the age factor, the LWR and water LW has significant negative correlation with vertebral BMP. Further investigation is needed to explore the relationship between bone marrow fat metabolism and angiogenesis.

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“…The water peak is originating mostly from red marrow, while the lipid peak arises mainly from yellow marrow . MRS has been used to illustrate the increase bone marrow fat content with age Chellinger et al 2000 ).…”

Section: Magnetic Resonance Imaging Of the Bone Marrowmentioning

confidence: 99%

Female Pelvis: Genital Organs

Forstner

Cunha²

2015

Imaging of Complications and Toxicity Following Tumor Therapy

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Medical Radiology-Diagnostic Imaging is a unique series that aims to document the most innovative technologies in all fi elds within diagnostic imaging and interventional radiology, thereby informing the physician in practice of the latest advances in diagnostic imaging and percutaneous imageguided minimally invasive procedures. Th e contents are intended to cover all organs, and all modern imaging techniques and image-guided treatment modalities, with special emphasis on applications in clinical practice. Each volume is a comprehensive reference book on a topical theme, and the editors are always experts of high international standing. Contributions are included from both clinicians and researchers, ensuring wide appeal. Medical Radiology -Radiation Oncology is a unique series that aims to document the most innovative technologies in all fi elds within radiology, thereby informing the physician in practice of the latest advances in diagnostic and treatment techniques. Th e contents range from contemporary statements relating to management for various disease sites to explanations of the newest techniques for tumor identifi cation and of mechanisms for the enhancement of radiation eff ects, with the emphasis on maximizing cure and minimizing complications. Each volume is a comprehensive reference book on a topical theme, and the editors are always experts of high international standing. Contributions are included from both clinicians and researchers, ensuring wide appeal. This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. AbstractA precise knowledge of antineoplastic drugs is an indispensable basis for the care of patients with cancer. The mechanisms of action and resistance, cross-resistance patterns, pharmacodynamics and pharmacokinetics, pharmacological interaction, and last but not least potential adverse effects should be part of this knowledge. As contemporary cancer care requires interdisciplinary and multiprofessional structures, the radiologist is an important a...

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Normal Lumbar Vertebrae: Anatomic, Age, and Sex Variance in Subjects at Proton MR Spectroscopy—Initial Experience

Cited by 113 publications

References 33 publications

Bone Marrow Edema in Vertebral Compression Fractures: Detection with Dual-Energy CT

Bone Marrow Edema in Vertebral Compression Fractures: Detection with Dual-Energy CT

Correlation between the bone marrow blood perfusion and lipid water content on the lumbar spine in female subjects

Female Pelvis: Genital Organs

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