Normal live births after intracytoplasmic sperm injection in a man with the rare condition of Eagle-Barrett syndrome (prune-belly syndrome)

Fleming, Steven D.; Varughese, Elizabeth; Hua, Vi-Khiem; Robertson, Amanda; Dalzell, F.; Boothroyd, Clare

doi:10.1016/j.fertnstert.2013.07.1994

Cited by 11 publications

(6 citation statements)

References 9 publications

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“…Division of the gonadal vessels is less likely when orchidopexy is performed early. There are multiple reports of live births resulting from intracytoplasmic sperm injection (ICSI) using spermatozoa from adult patients with PBS, further highlighting the importance of appropriate, timely management of the cryptorchid testes 58…”

Section: Management Issues In Pbsmentioning

confidence: 99%

<p>Prune belly syndrome: current perspectives</p>

Arlen

Nawaf

Kirsch

2019

PHMT

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Prune belly syndrome (PBS) is a rare but morbid congenital disease, classically defined by a triad of cardinal features that includes cryptorchidism, urinary tract dilation and laxity of the abdominal wall musculature. Children often require numerous surgical interventions including bilateral orchidopexy as well as individually tailored urinary tract and abdominal wall reconstruction. Along with the classic features, patients with PBS often experience gastrointestinal, orthopedic, and cardiopulmonary comorbidities.

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Section: Management Issues In Pbsmentioning

confidence: 99%

<p>Prune belly syndrome: current perspectives</p>

Arlen

Nawaf

Kirsch

2019

PHMT

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“…In PBS, the germinative epithelium is significantly reduced so testis descent should be performed in the newborn period to enhance the chances of fertility [ 5 – 8 , 17 ]. There are reports about live births of male infants resulting from intracytoplasmic sperm injection (ICSI) using spermatozoa from patients with PBS [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Study of Testicular Structure in Fetuses with Prune Belly Syndrome

Favorito

Costa

et al. 2017

Advances in Urology

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Purpose To compare the structure of the testis in fetuses with prune belly syndrome (PBS) to normal controls. Materials and Methods We studied 6 testes obtained from 3 fetuses with PBS and 14 testes from 7 male fetuses. The testicular specimens were cut into 5-μm thick sections and stained with hematoxylin and eosin (HE), to observe the seminiferous tubules; Weigert's solution to observe elastic fibers; and picrosirius red to observe collagen. The images were captured with an Olympus BX51 microscope and Olympus DP70 camera. The stereological analysis was done with the Image Pro and Image J programs. Means were statistically compared using the Mann–Whitney U test (p < 0.005). Results Quantitative analysis documented no differences (p = 0.4) in number of seminiferous tubules (ST) in PBS testes (mean = 8.87%, SD = 1.59), when compared to the control (mean = 11.4%, SD = 2.99) and no differences (p = 0.8) in diameter of ST in PBS testes (mean = 52.85 μm, SD = 1.58) when compared to the control group (mean = 53.17 μm, SD = 1.55), but we did observe a lower number (p = 0.0002) of Leydig cells in the PBS testes (mean = 67.03% and SD = 3.697) when compared to the control group (mean = 90.1% and SD = 2.986). Conclusions Our study showed a lower concentration of Leydig cells in the triad syndrome fetuses.

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“… [12] 2004 41 Success of bilateral orchidopexy and maintenance of sexual function among boys with PBS Fleming et al. [5] 2013 1 Live male birth following ICSI with use of ejaculated sperm from a man with PBS Dénes et al. [2] 2017 15 Gonadotropins and impaired semen parameters among patients with history of surgical reconstruction for PBS ICSI, intracytoplasmic sperm injection; PBS, prune belly syndrome.…”

mentioning

confidence: 99%

“…Third, prostatic and urethral anatomy is altered in PBS, resulting in prostatic secretory dysfunction and retrograde ejaculation [5] . These men can even present with Wolffian duct abnormalities resulting in agenesis of the seminal vesicles and vas deferens, thereby exacerbating secretory dysfunction [6] .…”

mentioning

confidence: 99%