Normal limits of high-resolution signal-averaged ECG parameters of Japanese adult men and women

Yakubo, Shuji; Ozawa, Yukio; Saito, Satoshi; Kasamaki, Yuji; Komaki, Koichi; Hanakawa, Kazuya; Sasaki, Yasuyuki; Aruga, Masakazu; Mataga, Izumi; Kanda, Tsugiyasu; Sekiguchi, Kazuhiko; Shimabukuro, Hiroyuki; Nakamura, Takashi; Okumura, Namiko

doi:10.1054/jelc.2000.7665

Cited by 8 publications

(8 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This seems important and interesting, given that a cohort of subjects studied was in the 18-45 year age range and did not report any subjective or objective complaints from cardiovascular system. The occurrence of VLPs in our epilepsy patients was significantly higher compared to healthy controls from our study, but also of importance is the general population data, in which VLPs were reported in 3-6% in otherwise asymptomatic subjects (Graham & Handelsman, 1998;Yakubo et al, 2000).…”

Section: Discussionsupporting

confidence: 50%

Analysis of ventricular late potentials in signal-averaged ECG of people with epilepsy

et al. 2011

View full text Add to dashboard Cite

Summary Purpose: There has been growing interest in cardiac disturbances in epilepsy patients and their etiologic role in the context of sudden death. Ventricular late potentials (VLPs) recorded on signal‐averaged electrocardiography (SAECG) reflects delayed ventricular depolarization and identifies the structural or functional substrate for the ventricular tachycardia in the reentry mechanism. Therefore, abnormal SAECG poses the potential of identifying patients at increased risk of malignant ventricular arrhythmias and sudden cardiac death. The aim of this exploratory study was to screen epilepsy patients who were treated with established doses of antiepileptic drugs (AEDs) on the presence of VLPs. Methods: Forty‐five consecutive patients with the diagnosis of epilepsy and 19 healthy volunteers, aged younger than 46 years, participated in the study. Exclusion criteria included symptoms or signs of diseases other than epilepsy, in particular relating to heart disease or medication influencing the cardiovascular system, as well as seizure reported by patients that occurred <3 days before the ECG examination. The electrocardiogram was recorded according to the standard protocol. The seizure frequency was calculated based on the available data of epileptic events within the preceding 3 months. Disease duration was estimated by determining the time from the first reported seizure to the present. Key Findings: There were 22 patients (48%) in the epilepsy group and only one patient (5%) in the control group fulfilling the criteria for VLP (p = 0.0005). Subsequently, epilepsy patients were divided into two subgroups according to VLP presence. Patients with VLP had longer disease duration (p = 0.03) compared to those without VLP. Similarly, patients with VLP more frequently had refractory epilepsy (p = 0.03) and had higher monthly seizure frequency (p = 0.02). Analysis of the proportions of generalized seizures (GS) and focal seizures (FS) showed a tendency for higher number of generalized tonic–clonic seizures in the VLP group, but this did not reach statistical significance (p = 0.06). VLP patients tended to be more often on polytherapy (defined as more than one AED per patient) (p = 0.07) as compared to epilepsy patients without VLP. However, if the numbers of AEDs per patients among the subgroups were compared, patients with VLP were treated with more AEDs than patients without VLP (p = 0.01). The study was not sufficiently powered to pinpoint any particular drug or AED combination to influence the appearance of VLP in epileptic patients. In particular, there was no difference in valproate or carbamazepine exposure, considering the percentage of patients exposed or the total daily dose administered. Significance: Epilepsy patients more frequently display abnormal SAECGs with VLPs as compared to the control population, and their presence correlates with the disease duration, uncontrolled seizures, and polytherapy. Further longitudinal studies are needed in order to stratify the risk of life‐threatening ventricula...

show abstract

Section: Discussionsupporting

confidence: 50%

Analysis of ventricular late potentials in signal-averaged ECG of people with epilepsy

et al. 2011

View full text Add to dashboard Cite

show abstract

“…However, it was not noted that the filtered fQRS duration may be different by gender. Over the past decade, there has been no modification of these normal values despite several published studies that indicate that there are gender‐related differences in the SAECG 3–8 …”

Section: What Are the Normal Values For Saecg?mentioning

confidence: 99%

“…The largest study was reported by Yakubo 6 . They recorded SAECGs in a Japanese population from 482 normal individuals, including 204 men and 278 women, using a bandwidth of 40–250 Hz.…”

Section: What Are the Normal Values For Saecg?mentioning

confidence: 99%

“…A summary of the normal values for SAECG are shown in Tables 1a 3,6,10,11 and b 4,5,7,12 . These normal values are generally expressed as the 90th percentile of the distribution of the upper limits of the fQRS duration and the LAS.…”

Section: What Are the Normal Values For Saecg?mentioning

confidence: 99%

“…3 The largest study was reported by Yakubo. 6 They recorded SAECGs in a Japanese population from 482 normal individuals, including 204 men and 278 women, using a bandwidth of 40-250 Hz. The normal values for the fQRS duration were ≤125 msec in men and ≤116 msec in women (P = 0.001).…”

Section: What Are the Normal Values For Saecg?mentioning

confidence: 99%

See 2 more Smart Citations