Normal Levels of Allo- but Increased Levels of Potentially Autoreactive Antibodies against ABO Histo-Blood Group Antigens in AIDS Patients

Friedli, Fabienne; Rieben, Robert; Wegmüller, E; Moerenhout, Martine; Nydegger, Urs E.

doi:10.1006/clin.1996.0099

Cited by 7 publications

(2 citation statements)

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“…[23][24][25][26] Consistent with the accepted belief that the response of the B-cell compartment to microbial products is derived preferentially from the activation of CD5 ϩ B-1 cells, [27][28][29] we recently demonstrated that B cells with receptors for blood group A carbohydrate determinants were found exclusively in a sIgM ϩ CD11b ϩ CD5 ϩ B-1 subpopulation in blood group O or B human peripheral blood. 13 Previous experiments by us and other researchers showed significant levels of naturally occurring anti-human blood group A-determinant Abs but undetectable levels of anti-human blood group B-determinant Abs in the sera from several strains of mice.…”

Section: Resultssupporting

confidence: 64%

The persistent elimination of B cells responding to blood group A carbohydrates by synthetic group A carbohydrates and B-1 cell differentiation blockade: novel concept in preventing antibody-mediated rejection in ABO-incompatible transplantation

Irei

Ohdan

Zhou

et al. 2007

Blood

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We demonstrated a novel strategy for specific and persistent inhibition of antibody (Ab) production against blood group A or B carbohydrate determinants necessary for successful ABO-incompatible transplantation. Similar to human blood group O or B individuals, mice have naturally occurring Abs against human blood group A carbohydrates in their sera. B cells with receptors for A carbohydrates in mice belonging to the CD5+CD11b+B-1a subset have phenotypic properties similar to those of human B cells. These cells could be temporarily eliminated by injecting synthetic A carbohydrates (GalNAcα1–3, Fucα1–2Gal) conjugated to bovine serum albumin (A-BSA) and anti-BSA Abs. In mice that received the injection of A-BSA/anti-BSA Abs, the serum levels of anti-A IgM were reduced, but immunization with human A erythrocytes resulted in increased serum levels of anti-A Abs. When combined with cyclosporin A (CsA) treatment, which blocks B-1a cell differentiation, and treatment with A-BSA/anti-BSA Abs, the serum levels of anti-A Abs were persistently undetectable in the mice even after the immunization. B cells with receptors for A carbohydrates were markedly reduced in these mice. These results are consistent with the hypotheses that treatment with A-BSA/anti-BSA Abs temporarily depletes B cells responding to A determinants, and CsA treatment prevents the replenishment of these cells.

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Section: Resultssupporting

confidence: 64%

The persistent elimination of B cells responding to blood group A carbohydrates by synthetic group A carbohydrates and B-1 cell differentiation blockade: novel concept in preventing antibody-mediated rejection in ABO-incompatible transplantation

Irei

Ohdan

Zhou

et al. 2007

Blood

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“…After removing 350 duplicates, 1826 articles underwent title and abstract screen with 93 records selected for full text review. A total of 43 publications were excluded, with 19 providing insufficient data for analysis, [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] 13 were considered irrelevant, [49][50][51][52][53][54][55][56][57][58][59][60][61] 8 were found to be reviews, 7,11,[62][63][64][65][66][67] and 3 were case reports. [68][69][70] The remaining 50 records were identified for inclusion and were analysed using both narrative synthesis and meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

ABO blood groups and risk of human immunodeficiency virus infection: A systematic review and meta‐analysis

Noori

Shokri

Nejadghaderi

et al. 2021

Reviews in Medical Virology

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The last few decades have seen a pandemic of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), which continues to cause substantial morbidity and mortality. ABO blood groups are anthropological and genetic characteristics of a population whose associations with HIV infection are still controversial. This systematic review with meta-analysis was undertaken to investigate whether certain blood groups may have associations with HIV infection. PubMed, Scopus and Web of Science databases were systematically searched as of 6 September 2021. Grey literature was identified through screening Google Scholar, and reference lists of relevant studies. All observational studies providing data on ABO blood group distribution among HIV-infected and uninfected participants were included. Using a random effect model, risk ratios (RR) and 95% confidence intervals (CIs) were pooled to quantify this relationship.Fifty eligible studies with a total of 3,068,244 participants and 6508 HIV-infected cases were included. The overall analysis found that blood group AB increased the risk of HIV infection by 19% as compared with non-AB blood groups (RR = 1.19, 95% CI: 1.03-1.39, p = 0.02). Pooled estimates for other blood groups failed to reach statistical significance. Subgroup analyses identified a positive relationship between AB blood group and HIV infection within Asia, patient populations (as opposed to blood donors and general populations), studies with lower sample sizes, high-income countries and studies with a moderate quality score. The sequential omission and re-analysis of studies within sensitivity analyses produced no change in the overall pooled effect. In conclusion, this study identified that blood group AB carriers were more susceptible to HIV infection. Future investigations should be directed toward clarification of the exact role of ABO blood groups in HIV infection and the possible underlying mechanisms.

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Autoantibodies to Leukocyte αMβ2 Integrin Glycoproteins in HIV Infection

Rubinstein

Farrington

O’Donnell

et al. 1999

Clinical Immunology

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Normal Levels of Allo- but Increased Levels of Potentially Autoreactive Antibodies against ABO Histo-Blood Group Antigens in AIDS Patients

Cited by 7 publications

References 0 publications

The persistent elimination of B cells responding to blood group A carbohydrates by synthetic group A carbohydrates and B-1 cell differentiation blockade: novel concept in preventing antibody-mediated rejection in ABO-incompatible transplantation

The persistent elimination of B cells responding to blood group A carbohydrates by synthetic group A carbohydrates and B-1 cell differentiation blockade: novel concept in preventing antibody-mediated rejection in ABO-incompatible transplantation

ABO blood groups and risk of human immunodeficiency virus infection: A systematic review and meta‐analysis

Autoantibodies to Leukocyte αMβ2 Integrin Glycoproteins in HIV Infection

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