Normal lactation and blood growth hormone studies

Spellacy, William N.; Buhi, William C.; Birk, S.A.

doi:10.1016/0002-9378(70)90592-2

Cited by 8 publications

(2 citation statements)

References 37 publications

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“…Several studies have shown that levels of HPL below 4μg/ml after 35 weeks indicate an increased risk of foetal distress, neonatal asphyxia and intrauterine growth retardation (IUGR) 9,10 . Of our cases of clinically suspected IUGR, oestriols were requested in 59.8% and HPL in 47.3%.…”

Section: Discussionmentioning

confidence: 85%

The Use of Placental Function Tests in a London Teaching Hospital

Jackson

Gouldes

1982

Int J Clinical Practice

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In 1978 a total of 2410 women were delivered at The London Hospital. Of these, 387 had placental function tests carried out during their pregnancy. The tests available were urinary oestriol and serum human placental lactogen (HPL). Women whose pregnancies were complicated by diabetes, hypertension, twins or suspected intrauterine growth retardation were most likely to have placental function tests carried out. They were requested less readily in cases of heart disease, ante-partum haemorrhage, threatened abortion and pre-eclampsia. In approximately 30% of the high risk pregnancies placental function tests were not done. More careful selection would make better use of the available tests.

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Section: Discussionmentioning

confidence: 85%

The Use of Placental Function Tests in a London Teaching Hospital

Jackson

Gouldes

1982

Int J Clinical Practice

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“…At variance, however, is a report in the rat (Schalch & Reichlin, 1966) where no increases in GH were observed 3-5 days before or after delivery. In man, both high and low values during pregnancy or lactation have been reported (see Spellacy & Buhi, 1969;Spellacy, Buhi & Birk, 1970, for reviews). The limitations of the assays employed in the early investigations may partly account for the discrepancies.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Prolactin and Growth Hormone to Mammary Function During Pregnancy and Lactation in the C3h/St Mouse

Sinha¹,

Selby²,

Vanderlaan³

1974

Journal of Endocrinology

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The secretion of prolactin and growth hormone (GH) in C3H/St mice, a strain having a high incidence of spontaneous mammary tumours, was studied at intervals throughout pregnancy and lactation. Serum and pituitary concentrations of prolactin and GH were measured by specific, homologous radioimmunoassays. Crude extracts of mouse placentae did not cross-react in these assays, indicating that the assay systems measured prolactin and GH of hypophysial origin. Except for a small, brief rise on day 5, prolactin secretion was low throughout most of pregnancy; the serum concentration of prolactin increased appreciably only near term. During lactation, prolactin in serum averaged from 5 to 10 times basal levels (30\p=n-\40 ng/ml) until day 15 of lactation, after which the concentration declined. In contrast, GH secretion increased early in pregnancy, the concentration rising both in serum and in the pituitary gland consistently after day 5. The serum concentrations reached 3\p=n-\10 times basal levels (8\p=n-\12 ng/ml) between days 10 and 20 of pregnancy. There were successive decreases in serum GH concentration after parturition; the concentration reached basal levels on day 5, but it increased thereafter and was maintained at over three times basal levels for the remainder of lactation. The levels of GH in serum were highly correlated with mammary DNA and RNA contents during pregnancy, while prolactin concentration was more strongly correlated with mammary function during lactation.

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Secretion of Prolactin and Growth Hormone by Adenohypophyses of Rhesus Monkeys in vitro

Nicoll

1972

Ciba Foundation Symposium ‐ Lactogenic Hormones

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Normal lactation and blood growth hormone studies

Cited by 8 publications

References 37 publications

The Use of Placental Function Tests in a London Teaching Hospital

The Use of Placental Function Tests in a London Teaching Hospital

Relationship of Prolactin and Growth Hormone to Mammary Function During Pregnancy and Lactation in the C3h/St Mouse

Secretion of Prolactin and Growth Hormone by Adenohypophyses of Rhesus Monkeys in vitro

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