Normal IPT and IBZM SPECT in drug-naive and levodopa-treated idiopathic restless legs syndrome

Abstract

Fourteen drug-naive and 11 levodopa-treated patients with idiopathic restless legs syndrome (RLS), and 10 controls age-matched to each RLS group separately were examined with polysomnography (PSG), [(123)I]-(N)-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane ((123)I-IPT) SPECT, and [(123)I]-(S)-2-hydroxy-3-iodo-6-methoxy-[(1-ethyl-2-pyrrolidinyl)methyl] benzamide ((123)I-IBZM) SPECT. Drug-naive and levodopa-treated patients with RLS and controls showed similar striatal dopamine transporter and dopamine D(2)-receptor binding, the latter declining with age. The authors conclude that striatal dopamine transporter and receptor density is normal in drug-naive and levodopa-treated patients with RLS.

Periodic leg movements in patients with Parkinson's disease are associated with reduced striatal dopamine transporter binding

“…SPECT and positron emission tomography (PET) have been used to study basal ganglia dopaminergic function in patients with PLMS and/or RLS [5][6][7][15][16][17]. However, results of those studies were contradictory, showing either a reduction [5] or no changes [16,17] of striatal dopamine D2 receptor occupancy using [ 123 I]IBZM SPECT.…”

Abnormally increased CSF 3-Ortho-methyldopa (3-OMD) in untreated restless legs syndrome (RLS) patients indicates more severe disease and possibly abnormally increased dopamine synthesis

“…While PET and SPECT imaging of the striatum held initial promise of linking dopamine abnormities to RLS, they have failed to reveal a consistent pattern of abnormalities. The dopamine-2 receptor binding potentials of RLS patients have been found to be increased, not changed, and even decreased (1)(2)(3)(4)(5)(6). The strongest support for dopaminergic pathology in RLS comes from recent autopsy data that somewhat unexpectedly found increases in both total and phosphorylated tyrosine hydroxylase (TH) in the putamen from RLS patients.…”

Alvászavarok Parkinson-kórban: megjelenés, kivizsgálás, terápiás lehetőségek

“…Más tanulmá-nyok inkább csak "véletlen" egybeesésnek tekintik közös meglétüket. Számos vizsgálat igazolta, hogy a két betegségben észlelt dopaminerg hipofunkciók mögött külön-böző patomechanizmusok állnak [19,20]. A substantia nigra vastartalma PK-ban emelkedett, RLS-ben pedig inkább csökkent.…”