Normal Interdigitation Zone Loss by Motion-Tracked OCT

Park, Dong Wouk; Lujan, Brandon J.

doi:10.1016/j.oret.2017.05.005

Cited by 10 publications

(7 citation statements)

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“…The presence of foveal bulge, foveal depression, or inner-retinal-layer thinning (all as seen on SD-OCT) was considered to represent confirmation of foveal area. For inclusion, all of the images were reviewed to confirm centered scans, a lack of artifacts, 12,13 and a signal quality > 20 dB.…”

Section: Imaging Of Outer-retinal Layermentioning

confidence: 99%

Interdigitation Zone Change According to Glaucoma-Stage Advancement

Lee

Bak

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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To compare the macular interdigitation zone (IZ) of normal eyes with eyes showing different normal-tension glaucoma (NTG) stages. METHODS. Forty-two normal eyes (age, 56 ± 5.4 years), 45 pre-perimetric eyes (age, 59 ± 6.9 years), 51 mild-to-moderate glaucoma eyes (age, 58 ± 7.2 years; mean deviation [MD],-5.5 ± 3.0 dB), and 50 severe glaucoma eyes (age, 59 ± 6.9 years; MD,-15.1 ± 5.4 dB) were enrolled. All of the subjects underwent high-resolution spectral-domain optical coherence tomography (SD-OCT) to obtain 19 horizontal and 19 vertical macular B-scans 9 mm in length. The en face image of the scan area was divided into 589 rectangular boxes (side length of 375 μm). The IZ locations were marked on the corresponding image boxes. The IZ area was then quantified according to the number of boxes showing IZs among the 589 total boxes. RESULTS. The IZ area in the severe glaucoma eyes was significantly smaller than in the mild-to-moderate glaucoma eyes (28.99 ± 7.88 mm 2 vs. 40.79 ± 7.46 mm 2 ; P < 0.001), was smaller in the mild-to-moderate glaucoma eyes than in the pre-perimetric glaucoma eyes (40.79 ± 7.46 mm 2 vs. 49.92 ± 8.10 mm 2 ; P < 0.001), and was smaller still in the pre-perimetric glaucoma eyes than in the normal eyes (49.92 ± 8.10 mm 2 vs. 56.85 ± 7.94 mm 2 ; P < 0.001). In the 146 NTG eyes, a statistically significant correlation was found between IZ area and MD (r = 0.64; P < 0.001). CONCLUSIONS. SD-OCT revealed a reduction in IZ area in NTG eyes, and the extent of the reduction was positively associated with glaucoma severity. These findings suggest, though tentatively, that changes in the outer retinal layer can occur in the course of glaucoma progression.

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Section: Imaging Of Outer-retinal Layermentioning

confidence: 99%

Interdigitation Zone Change According to Glaucoma-Stage Advancement

Lee

Bak

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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“…Park et al reported finding reduced reflectivity of the IZ due to the tilted OCT image when using the Heidelberg Spectralis (Heidelberg Engineering, Heidelberg, Germany) and that the hyper-reflective Henle fiber layer is a telltale sign. 14 Meanwhile, Otani et al showed by intentionally tilting the OCT image to visualize the Henle fiber layer when using the same spectral domain OCT device as ours, their OCT image could visualize the IZ in both the hyper-reflective Henle layer side and the opposite side. 15 This discrepancy indicates that this phenomenon might be affected by the apparatus.…”

Section: Discussionmentioning

confidence: 79%

Obscured interdigitation zone at the early stage of gyrate atrophy: A case report

Nitta

Mukai

Akiyama

2022

American Journal of Ophthalmology Case Reports

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Purpose To report an early stage of gyrate atrophy (GA) of the retina and choroid for which spectral-domain optical coherence tomography (SD-OCT) images revealed an obscured interdigitation zone (IZ). Observation A 13-year-old boy was referred to our department due to blurred vision in his left eye. Best corrected visual acuity was 20/20 and 20/25 in the right and left eye, respectively. Fundus examination revealed scalloped atrophic peripheral chorioretinal lesions in both eyes. Concentrations of plasma and urine ornithine were 1192 nmol/mL and 1930 μmol/g·cre, respectively. Consequently, he was diagnosed with GA. Although Goldmann perimetry found no abnormalities, electroretinogram (ERG) revealed loss of the rod responses and significant attenuation of the cone responses in both eyes. Detailed analysis of the posterior part of the fundus using multifocal electroretinogram showed poor responses, specifically in the nasal macular area of the left eye. SD-OCT showed an obscured IZ corresponding to the attenuated cone response determined by ERG. There was preservation of the retinal pigment epithelium, ellipsoid zone and external limiting membrane. Conclusions and Importance Obscured IZ during early stage GA was confirmed in a teenage patient with a chief complaint of blurred vision. OCT is useful in the detection of minute morphological changes that occur earlier in GA.

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“…It is possible that a small fraction of our subjects had a physiologic IZ area smaller than the 9 mm 2 scan area imaged on SD-OCT, which could overestimate their extent of IZ attenuation [43]. Qualitative studies have also suggested that IZ reflectivity is influenced by the angle at which the eye is imaged [44]. Due to these considerations, we believe IZ loss may represent a more consistent measure of IZ disruption than IZ attenuation.…”

Section: Plos Onementioning

confidence: 89%

Early-stage macular telangiectasia type 2 vascular abnormalities are associated with interdigitation zone disruption

2021

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Purpose To investigate the relationship between disruption in different photoreceptor layers and deep capillary plexus (DCP) telangiectasias in eyes with macular telangiectasia type 2 (MacTel). Methods 35 eyes (21 patients) with MacTel imaged with optical coherence tomography angiography (OCTA) were included. Circumscribed areas of DCP telangiectasia were traced from OCTA slabs and the corresponding spectral-domain OCT (SD-OCT) slabs were used to visualize the photoreceptor layer interdigitation zone (IZ) and ellipsoid zone (EZ). IZ attenuation, IZ loss, and EZ loss were graded by reviewing en face SD-OCT slabs for hypo-reflective areas and confirming their status on cross-sectional views. Total area of photoreceptor disruption and overlap with DCP telangiectasia were evaluated with respect to OCT-based MacTel stage. Longitudinal changes were evaluated in a subset of patients with follow-up imaging. Results Overlap of DCP telangiectasia with IZ attenuation significantly decreased with MacTel severity, while overlap with IZ and EZ loss significantly increased. Overlap with IZ loss peaked in moderate MacTel (Stages 3–5). Longitudinal imaging showed that new EZ loss at 6 months was largely predicted by baseline IZ loss. Conclusions Worsening MacTel severity is characterized by greater overlap between DCP telangiectasia and zones of increasing severity of photoreceptor disruption, with EZ loss enlarging over time within areas of preexisting IZ disruption. We suggest that IZ disruption may indicate early photoreceptor dysfunction that eventually progresses to EZ loss, with IZ loss being a more reliable metric than IZ attenuation. Additional studies will be necessary to further explore long-term photoreceptor changes and evaluate their relationship with visual function in MacTel.

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Normal Interdigitation Zone Loss by Motion-Tracked OCT

Cited by 10 publications

References 0 publications

Interdigitation Zone Change According to Glaucoma-Stage Advancement

Interdigitation Zone Change According to Glaucoma-Stage Advancement

Obscured interdigitation zone at the early stage of gyrate atrophy: A case report

Early-stage macular telangiectasia type 2 vascular abnormalities are associated with interdigitation zone disruption

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