Normal Human Left and Right Ventricular and Left Atrial Dimensions Using Steady State Free Precession Magnetic Resonance Imaging

Hudsmith, Lucy; Petersen, Steffen E.; Francis, Jane M; Robson, Matthew D.; Neubauer, Stefan

doi:10.1080/10976640500295516

Cited by 540 publications

(501 citation statements)

References 16 publications

Supporting

Mentioning

426

Contrasting

Unclassified

Order By: Relevance

“…The other mean variables (EDVI, ESVI, and SVI) were found to reduce with age by varying amounts. These patterns of change over time are most similar to those reported by Hudsmith et al2 at 1.5T, where they compared cohorts of volunteers in groups with age stratification <35 years and >35 years. Similar patterns of change over time are also presented by Alfakih et al1 and Macieira et al3 at 1.5T.…”

Section: Discussionsupporting

confidence: 86%

3T MRI investigation of cardiac left ventricular structure and function in a UK population: The tayside screening for the prevention of cardiac events (TASCFORCE) study

Gandy

Lambert

Belch

et al. 2016

Magnetic Resonance Imaging

View full text Add to dashboard Cite

PurposeTo scan a volunteer population using 3.0T magnetic resonance imaging (MRI). MRI of the left ventricular (LV) structure and function in healthy volunteers has been reported extensively at 1.5T.Materials and MethodsA population of 1528 volunteers was scanned. A standardized approach was taken to acquire steady‐state free precession (SSFP) LV data in the short‐axis plane, and images were quantified using commercial software. Six observers undertook the segmentation analysis.ResultsMean values (±standard deviation, SD) were: ejection fraction (EF) = 69 ± 6%, end diastolic volume index (EDVI) = 71 ± 13 ml/m2, end systolic volume index (ESVI) = 22 ± 7 ml/m2, stroke volume index (SVI) = 49 ± 8 ml/m2, and LV mass index (LVMI) = 55 ± 12 g/m2. The mean EF was slightly larger for females (69%) than for males (68%), but all other variables were smaller for females (EDVI 68v77 ml/m2, ESVI 21v25 ml/m2, SVI 46v52 ml/m2, LVMI 49v64 g/m2, all P < 0.05). The mean LV volume data mostly decreased with each age decade (EDVI males: –2.9 ± 1.3 ml/m2, females: –3.1 ± 0.8 ml/m2; ESVI males: –1.3 ± 0.7 ml/m2, females: –1.7 ± 0.5 ml/m2; SVI males: –1.7 ± 0.9 ml/m2, females: –1.4 ± 0.6 ml/m2; LVMI males: –1.6 ± 1.1 g/m2, females: –0.2 ± 0.6 g/m2) but the mean EF was virtually stable in males (0.6 ± 0.6%) and rose slightly in females (1.2 ± 0.5%) with age.ConclusionLV reference ranges are provided in this population‐based MR study at 3.0T. The variables are similar to those described at 1.5T, including variations with age and gender. These data may help to support future population‐based MR research studies that involve the use of 3.0T MRI scanners. J. Magn. Reson. Imaging 2016;44:1186–1196.

show abstract

Section: Discussionsupporting

confidence: 86%

3T MRI investigation of cardiac left ventricular structure and function in a UK population: The tayside screening for the prevention of cardiac events (TASCFORCE) study

Gandy

Lambert

Belch

et al. 2016

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…However, accuracy of RV volumes and function by these techniques may be inaccurate due to the anatomical location and complex geometric structure. Cardiovascular magnetic resonance (CMR) offers superior three dimensional representation of the RV, leading to a more accurate and reproducible assessment of RV function [8]. We therefore sought to assess the impact of RV function on outcomes in HF patients undergoing CRT implantation using CMR.…”

Section: Introductionmentioning

confidence: 99%

Right ventricular dysfunction is a predictor of non-response and clinical outcome following cardiac resynchronization therapy

Alpendurada

Guha

Sharma

et al. 2011

Journal of Cardiovascular Magnetic Resonance

View full text Add to dashboard Cite

BackgroundCardiac resynchronization therapy (CRT) is an established treatment in advanced heart failure (HF). However, an important subset does not derive a significant benefit. Despite an established predictive role in HF, the significance of right ventricular (RV) dysfunction in predicting clinical benefit from CRT remains unclear. We investigated the role of RV function, assessed by cardiovascular magnetic resonance (CMR), in predicting response to and major adverse clinical events in HF patients undergoing CRT.MethodsSixty consecutive patients were evaluated with CMR prior to CRT implantation in a tertiary cardiac centre. The primary end-point was a composite of death from any cause or unplanned hospitalization for a major cardiovascular event. The secondary end-point was response to therapy, defined as improvement in left ventricular ejection fraction ≥ 5% on echocardiography at one year.ResultsEighteen patients (30%) met the primary end-point over a median follow-up period of 26 months, and 27 out of 56 patients (48%) were considered responders to CRT. On time-to-event analysis, only atrial fibrillation (HR 2.6, 95% CI 1.02-6.84, p = 0.047) and RV dysfunction, either by a reduced right ventricular ejection fraction-RVEF (HR 0.96, 95% CI 0.94-0.99, p = 0.006) or tricuspid annular plane systolic excursion-TAPSE (HR 0.88, 95% CI, 0.80-0.96, p = 0.006), were significant predictors of adverse events. On logistic regression analysis, preserved RVEF (OR 1.05, 95% CI 1.01-1.09, p = 0.01) and myocardial scar burden (OR 0.90, 95% CI 0.83-0.96, p = 0.004) were the sole independent predictors of response to CRT. Patients with marked RV dysfunction (RVEF < 30%) had a particularly low response rate (18.2%) to CRT.ConclusionsRight ventricular function is an important predictor of both response to CRT and long-term clinical outcome. Routine assessment of the right ventricle should be considered in the evaluation of patients for CRT.

show abstract

“…Using the multiple short-axis slice-summation method, contiguous slices of short-axis cine datasets are acquired from the base of the left ventricle to the apex, covering the myocardium completely. This approach has been shown to provide excellent accuracy (21) and low interstudy variability (22); normal values are available for healthy subjects (23). A less commonly used approach covers the entire LV myocardium with multiple radial long-axis slices, and has been shown to yield similarly robust values of interobserver variability (24).…”

Section: Cmr For the Assessment Of Rv And LV Size And Functionmentioning

confidence: 99%

The emerging clinical role of cardiovascular magnetic resonance imaging

Kumar¹,

Patton²,

Friedrich³

2010

Canadian Journal of Cardiology

View full text Add to dashboard Cite

Normal Human Left and Right Ventricular and Left Atrial Dimensions Using Steady State Free Precession Magnetic Resonance Imaging

Abstract: We have produced a large database of age-related normal ranges for left and right ventricular function and left atrial function in males and females. This will allow accurate interpretation of clinical and research datasets.

Cited by 540 publications

References 16 publications

3T MRI investigation of cardiac left ventricular structure and function in a UK population: The tayside screening for the prevention of cardiac events (TASCFORCE) study

3T MRI investigation of cardiac left ventricular structure and function in a UK population: The tayside screening for the prevention of cardiac events (TASCFORCE) study

Right ventricular dysfunction is a predictor of non-response and clinical outcome following cardiac resynchronization therapy

The emerging clinical role of cardiovascular magnetic resonance imaging

Contact Info

Product

Resources

About