Normal Hearing Is Required for the Emergence of Long-Lasting Inhibitory Potentiation in Cortex

Han, Xu; Kotak, Vibhakar C.; Sanes, Dan H.

doi:10.1523/jneurosci.4554-09.2010

Cited by 53 publications

(49 citation statements)

References 135 publications

(191 reference statements)

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“…Instead, trafficking of α4βδ−GABA A Rs to the plasma membrane is regulated by network activity (Joshi and Kapur, 2009). BDNF is one molecule released in response to neural activity (Lu, 2003, Tan et al, 2008, Xu et al, 2010) that also regulates the synthesis (Roberts et al, 2006) and trafficking of α4βδ−GABA A Rs from the cytoplasm to the plasma membrane (Joshi and Kapur, 2009). BDNF is released from excitatory neurons but not from GABAergic interneurons (Gorba and Wahle, 1999).…”

Section: Discussionmentioning

confidence: 99%

α4βδ-GABAARs in the hippocampal CA1 as a biomarker for resilience to activity-based anorexia

et al. 2014

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Anorexia nervosa (AN) is a psychiatric illness characterized by restricted eating and an intense fear of gaining weight. Most individuals with AN are females, diagnosed first during adolescence, 40% to 80% of whom exhibit excessive exercise, and an equally high number with a history of anxiety disorder. We sought to determine the cellular basis for individual differences in AN vulnerability by using an animal model, activity-based anorexia (ABA), that is induced by combining food restriction (FR) with access to a running wheel that allows voluntary exercise. Previously, we showed that by the 4th day of FR, the ABA group of adolescent female rats exhibit > 500% greater levels of non-synaptic α4βδ−GABAARs at the plasma membrane of hippocampal CA1 pyramidal cell spines, relative to the levels found in age-matched controls that are not FR and without wheel access. Here, we show that the ABA group exhibits individual differences in body weight loss, with some losing nearly 30%, while others lose only 15%. The individual differences in weight loss are ascribable to individual differences in wheel activity that both precedes and concurs with days of FR. Moreover, the increase in activity during FR correlates strongly and negatively with α4βδ−GABAAR levels (R= - 0.9, p<0.01). This negative correlation is evident within 2 days of FR, before body weight loss approaches life-threatening levels for any individual. These findings suggest that increased shunting inhibition by α4βδ−GABAARs in spines of CA1 pyramidal neurons may participate in the protection against the ABA-inducing environmental factors of severe weight loss by suppressing excitability of the CA1 pyramidal neurons which, in turn, is related indirectly to suppression of excessive exercise. The data also indicate that, although exercise has many health benefits, it can be maladaptive to individuals with low levels of α4βδ−GABAARs in the CA1, particularly when combined with FR.

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Section: Discussionmentioning

confidence: 99%

α4βδ-GABAARs in the hippocampal CA1 as a biomarker for resilience to activity-based anorexia

et al. 2014

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“…An additional level of complexity results from the fact that BDNF can also increase the number of GABAergic terminals [34-36] and regulate the expression of the chloride transporter KCC2 (see below) [37-39]. BDNF-mediated forms of I-LTP reportedly occur in a restricted time window when GABAergic circuits are maturing [22,24,40-41]. Consistent with this observation the direction of BDNF effects is likely to be developmentally regulated.…”

Section: Presynaptic Forms Of Inhibitory Synaptic Plasticitymentioning

confidence: 99%

Long-term plasticity at inhibitory synapses

Castillo

Chiu

Carroll

2011

Current Opinion in Neurobiology

200

166

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Experience-dependent modifications of neural circuits and function are believed to heavily depend on changes in synaptic efficacy such as LTP/LTD. Hence, much effort has been devoted to elucidating the mechanisms underlying these forms of synaptic plasticity. While most of this work has focused on excitatory synapses, it is now clear that diverse mechanisms of long-term inhibitory plasticity have evolved to provide additional flexibility to neural circuits. By changing the excitatory/inhibitory balance, GABAergic plasticity can regulate excitability, neural circuit function and ultimately, contribute to learning and memory, and neural circuit refinement. Here we discuss recent advancements in our understanding of the mechanisms and functional relevance of GABAergic inhibitory synaptic plasticity.

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“…The large perceptual effect of adult CHL cannot be explained entirely by the cellular changes that occur following early onset CHL (Xu et al, 2007(Xu et al, , 2010Takesian et al, 2010). For example, CHL leads to a reduction in the strength of cortical inhibition when induced at P10, but not at P83 (Takesian et al, 2012).…”

Section: Age-dependent Effect Of Hearing Loss Onsetmentioning

confidence: 99%

A Sensitive Period for the Impact of Hearing Loss on Auditory Perception

Buran¹,

Sarro²,

Manno³

et al. 2014

J. Neurosci.

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Manipulations of the sensory environment typically induce greater changes to the developing nervous system than they do in adulthood. The relevance of these neural changes can be evaluated by examining the age-dependent effects of sensory experience on quantitative measures of perception. Here, we measured frequency modulation (FM) detection thresholds in adult gerbils and investigated whether diminished auditory experience during development or in adulthood influenced perceptual performance. Bilateral conductive hearing loss (CHL) of Ϸ30 dB was induced either at postnatal day 10 or after sexual maturation. All animals were then trained as adults to detect a 5 Hz FM embedded in a continuous 4 kHz tone. FM detection thresholds were defined as the minimum deviation from the carrier frequency that the animal could reliably detect. Normal-hearing animals displayed FM thresholds of 25 Hz. Inducing CHL, either in juvenile or adult animals, led to a deficit in FM detection. However, this deficit was greater for juvenile onset hearing loss (89 Hz) relative to adult onset hearing loss (64 Hz). The effects could not be attributed to sensation level, nor were they correlated with proxies for attention. The thresholds displayed by CHL animals were correlated with shallower psychometric function slopes, suggesting that hearing loss was associated with greater variance of the decision variable, consistent with increased internal noise. The results show that decreased auditory experience has a greater impact on perceptual skills when initiated at an early age and raises the possibility that altered development of CNS synapses may play a causative role.

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Normal Hearing Is Required for the Emergence of Long-Lasting Inhibitory Potentiation in Cortex

Cited by 53 publications

References 135 publications

α4βδ-GABAARs in the hippocampal CA1 as a biomarker for resilience to activity-based anorexia

α4βδ-GABAARs in the hippocampal CA1 as a biomarker for resilience to activity-based anorexia

Long-term plasticity at inhibitory synapses

A Sensitive Period for the Impact of Hearing Loss on Auditory Perception

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