Normal endometrial cells in cervical cytology: systematic review of prevalence and relation to significant endometrial pathology

Canfell, Karen; Kang, Yoon Jung; Clements, Mark; Moa, Aye; Beral, Valerie

doi:10.1258/jms.2008.008069

Cited by 10 publications

(7 citation statements)

References 40 publications

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“…Although mass screening program is not designed to detect endometrial carcinoma, early detection of such cases has benefit for involved asymptomatic patients 8 . In one study 48% of endometrial carcinoma preceded abnormal cervico‐vaginal cytology 9,10 …”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of dilatation and curettage for abnormal uterine bleeding

Yarandi¹,

Izadi-Mood

Eftekhar³

et al. 2010

J of Obstet and Gynaecol

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Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of dilatation and curettage for abnormal uterine bleeding

Yarandi¹,

Izadi-Mood

Eftekhar³

et al. 2010

J of Obstet and Gynaecol

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“…However, the various studies published since 1970 shows were listed below-( The reported prevalence of normal endometrial cells in all smears varied between 0.1% to 1.4% [38] and Atypical glandular cells ranging from 0.18 to 0.74% [39], [40] The increased prevalence of endometrial cells in our study may be because of confinement of patients selection was only from bleeding history cases in which some pathology must be there. The presence of endometrial glandular cells was found to indicate a five times greater risk of endometrial disease [41].…”

Section: Discussionmentioning

confidence: 89%

Manual Liquid Based Cytology in Diagnosis of Gynecologic Pathology

Manoli¹

2016

CRJ

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Abnormal uterine bleeding (AUB) is a commonly encountered complaint in gynecology department. Endometrial cancer is the fourth most common malignancy in women and the most frequent gynecological cancer in developed countries. With 5,28, 000 new cases every year, cervical cancer is the fourth most common cancer affecting women worldwide, after breast, colorectal, and lung cancers. Though the cytological examination has been the mainstay for early detection of cervical cancer, and found to be useful in detection of endometrial cancer, its widespread use has not been possible in the developing countries due to paucity of resources, man power and other facilities Its sensitivity reduces to less than 50% when there is presence of obscuring blood, inflammation or thick areas of overlapping epithelial cells. Manual Liquid Based Cytology (MLBC) is a cost effective technique that enables cells to be suspended in a monolayer and thus improve detection of precursor lesions and specimen adequacy. The residual sample can be used for other tests like Cell block and immunocytochemistry. Objectives: 1. To improve the diagnosis of gynecological cancers by a method called as Manual Liquid Based Cytology (MLBC). 2. To study a cost effective method of studying both endometrial and cervical cancer with help of ancillary techniques like cellblock, immunocytochemistry 3To compare the findings between conventional pap smear (CPS) and MLBC in detection of gynecological conditions of endometrium and cervix. Methodology: Samples were collected using Ayres spatula by split sample technique from transformation zone of cervix which included outpatients of gynecology dept. The women were aged between 20-60 years, 82 cases with bleeding history were taken to study endometrial pathology, while 100 cases of white discharge per vagina were selected to study the cervix. 60 cases were later subjected to ancillary studies like cellblock with Immunocytochemistry. Histopathological correlation was done for cases wherever possible. Results: The study on endometruim showed MLBC is more sensitive and specific than CPS in diagnosis of malignant lesions. The contingency coefficient for LBC/Histopathology V/s CPS/Histopathology was 0.572 V/s 0.556. It was observed for cervical lesion that increased detection rate was 150% for low grade intraepithelial lesion. The Positive predictive value for diagnosing neoplastic lesions on cell blocks was 75%, while Concordance Rate of CB/Histopathology Vs CPS/Histopathology was 74% vs. 54%. Conclusion: MLBC is a cost effective method for detections of cancerous lesions of endometruim and cervix.

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“…Recently a meta-analysis determined that a TVUS result of 5 mm or less reduces the risk of endometrial cancer by 84%. 6,10 In Some cases, it is recommended that hysteroscopy and endometrial sampling should be done if clinical suspicion is higher. 1,11 In the women with diabetes mellitus and obesity has been difficult to the assessing endometrial thickness, but models has been planned to take personal characteristics into account when predicting the risk of malignancies.…”

Section: 31mentioning

confidence: 99%

“…A major growth may be need direct referral to 'one stop' specialist clinics. 10,11,6,30 In advance clinical practices, various investigating tools are available to provide clinical evaluation, including ultrasound, hysteroscopy and endometrial sampling techniques like pippelle.…”

Section: 31mentioning

confidence: 99%

POSTMENOPAUSAL UTERINE BLEEDING; CORRELATION OF THE FINDINGS OF TRANSVAGINAL ULTRASONOGRAPHY & ENDOMETRIAL SAMPLING IN PATIENT

Memon

Munwar²,

Bilquees³

et al. 2016

TPMJ

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ABSTRACT… Objectives: To find out the significance of the transvaginal sonography (TVS) in postmenopausal women (PMW) with postmenopausal bleeding (PMB) and compare it with the histopathological diagnosis at curettage, so that unnecessary operations could be avoided. Study Design: Descriptive study. Setting: Radiological Department for TVS and H/P at the Department of Gynecology & Obstetrics (Gynae: Unit IV) at Liaquat University Medical, Health Sciences Hospital Jamshoro and Hyderabad. Period: September 2010 to September 2011. Material and Methods: The present study was conducted on patients with postmenopausal bleeding. Results: The mean age + SD of the women was 51 + 3.1 years, ranging from a minimum of 49 to 55 years. The mean endometrial thickness was from 1.8-15mm. Transvaginal Sonography and Histopathological Findings: Histopathological findings revealed endometrial atrophy in 64 (57.14%) patients, Endometrial hyperplasia in 24(21.4%), endometrial polyp in 7(6.25%), Endometrial carcinoma in 8 (7.14%), Pyometra in 5(4.46%) and Fibroid uterus in 4(3.57%). With a cut off value of 4mm endometrial thickness, TVS showed a sensitivity of 100%, specificity of 73.33%, a positive predictive value of 76.47%, a negative predictive value 100% and an accuracy of 85.71%. At a cut off limit of 5mm endometrial thickness (endometrium >5mm indicating pathology), the sensitivity of the present study was 92.3% and the specificity was 86.6 %. The positive predictive value was 85.71%, the negative predictive value was 92.86 % and the accuracy was 89 %. Conclusion: TVS is a useful tool to triage post menopausal women with bleeding and avoid un convenient invasive procedure.

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Normal endometrial cells in cervical cytology: systematic review of prevalence and relation to significant endometrial pathology

Cited by 10 publications

References 40 publications

Diagnostic accuracy of dilatation and curettage for abnormal uterine bleeding

Diagnostic accuracy of dilatation and curettage for abnormal uterine bleeding

Manual Liquid Based Cytology in Diagnosis of Gynecologic Pathology

POSTMENOPAUSAL UTERINE BLEEDING; CORRELATION OF THE FINDINGS OF TRANSVAGINAL ULTRASONOGRAPHY & ENDOMETRIAL SAMPLING IN PATIENT

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